UM Biophysics Faculty | Richard R Neubig

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Richard R Neubig

Professor - Pharmacology, M.D., Ph.D.

Neubig

Harvard Medical School

Dept: Pharmacology

Office Address: 2220D MSRB III

Phone: (734) 763-3650

Email: rneubig@umich.edu

Neubig Lab Home Page

The general theme of work in Dr. Neubig's laboratory is the cellular
and molecular understanding of guanine nucleotide regulatory protein (G
protein) mechanisms. G proteins are involved in the control of many cellular processes from cell growth and differentiation to learning and memory. A major focus of the lab is on a novel protein family called Regulators of G protein signaling. These proteins stimulate the breakdown of GTP by the G proteins leading to rapid turn-off of the signaling. A review from our lab in Nature Reviews Drug Discovery (2002) describes the potential for designing drugs to block the action of RGS proteins to enhance signaling which could lead to improved therapies for pain, Alzheimer's, and cancer.

To better understand the potential of RGS proteins as therapeutic targets we are doing both in vivo (mouse knockout) studies and in vitro (computer-based drug design, high throughput screening, and structural - x-ray and NMR) studies.

Dr. Neubig is Associate Director of the new Center for Chemical Genomics (http://ccg.lsi.umich.edu) which uses high throughput screening approaches to identify small molecule inhibitor candidates. The biophysical analysis inhibitor mechanisms and the structural basis of their binding to the RGS targets will be an important part of our future studies.

Representative Publications

1: Roof RA, Jin Y, Roman DL, Sunahara RK, Ishii M, Mosberg HI, Neubig RR.
Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins.
Chem Biol Drug Des. 67:266-74, 2006.

2: Fu Y, Huang X, Zhong H, Mortensen RM, D'Alecy LG, Neubig RR.
Endogenous RGS proteins and Galpha subtypes differentially control muscarinic and adenosine-mediated chronotropic effects.
Circ Res. 98:659-66, 2006.

3: Zhong H, Wade SM, Woolf PJ, Linderman JJ, Traynor JR, Neubig RR.
A spatial focusing model for G protein signals. Regulator of G protein signaling (RGS) protein-mediated kinetic scaffolding.
J Biol Chem. 2003 Feb 28;278(9):7278-84.

4: Sarvazyan NA, Lim WK, Neubig RR.
Fluorescence analysis of receptor-G protein interactions in cell membranes.
Biochemistry. 2002 Oct 22;41(42):12858-67.

5: Neubig RR, Siderovski DP.
Regulators of G-protein signalling as new central nervous system drug targets.
Nat Rev Drug Discov. 2002 Mar;1(3):187-97. Review.

6: Chung DA, Zuiderweg ER, Fowler CB, Soyer OS, Mosberg HI, Neubig RR.
NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.
Biochemistry. 2002 Mar 19;41(11):3596-604.

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Biophysics Research Division University of Michigan 4028 Chemistry Building 930 North University Avenue Ann Arbor, MI 48109-1055 UMsitemaker	Phone: (734) 763-6722 Fax: (734) 764-3323 E-mail: biophysics@umich.edu Last Updated: 5/25/2006 © Copyright 2006 University of Michigan