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CURRICULUM VITAE

Name: Stephen Cooper

Date and Place of Birth: August 6, 1937, Brooklyn, New York

Marital Status: Married, to Alexandra (Sandi)

Children: Eric, born October 31, 1962

                Michael, born August 1, 1966

Grandchildren: Moses, Raya, Joshua, Leo, and Cully

Education:

a. Stuyvesant High School, New York City

b. Union College, Schenectady, New York B.A. 1959 (Philosophy)

c. Rockefeller Institute, New York City Ph.D. 1963 (Microbiology)

 Graduate Training: 1959-63 Rockefeller University with Dr. Norton Zinder

1963-64 NSF Fellow, University Institute of Microbiology, Copenhagen, Denmark (Dr. Ole Maaloe)

1964-65 NSF Fellow, National Research Council, Microbial Genetics Research Unit, London, England (Dr. William Hayes)

1965-66 Research Associate, Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts (Dr. Kivie Moldave)

 Additional Scientific Training:

1976 Imperial Cancer Research Fund, Mill Hill, London, England (6 months)

1989 Max Planck Institute fur Entwicklungsbiologie, Tubingen, Germany (6 months), with Uli Schwarz and J.-V. Holtje.

Teaching Appointments:

1966-70 Assistant Research Professor, Department of Pediatrics, State University of New York at Buffalo

1967-70 Assistant Research Professor, Department of Biochemistry, State University of New York at Buffalo

1969-70 Lecturer, Department of Biology, State University of New York at Buffalo

1970-78 Associate Professor, Department of Microbiology, The University of Michigan Medical School

1978- Professor, Department of Microbiology, The University of Michigan Medical School

1981 Visiting Professor, Laboratoire de Biostatistique, University of Paris, Paris, France

1990 Dozor Fellow and Visiting Professor, Ben-Gurion University of the Negev, to give one month course on Prokaryotic and Eukaryotic Cell Growth

 Honors and Awards: 1963-64 National Science Foundation Fellowship, University Institute of Microbiology, Copenhagen, Denmark (Dr. Ole Maaloe)

1964-65 National Science Foundation Fellowship, National Research Council, Microbial Genetics Research Unit, London, England (Dr. William Hayes)

1976 Fogarty International Fellow: Imperial Cancer Research Fund, London, England

1981 Visiting Professor, Laboratoire de Biostatistique, University of Paris, Paris, France

1982 Quest for Technology Award, by Control Data Corporation, for potential application of bioscience to technology.

1986 Max-Planck Fellow, Tubingen, West Germany

1992-1994 Foundation for Microbiology Lecturer, American Society for Microbiology

 Current Membership in Professional Societies:

American Society for Microbiology

Committee and Administrative Services:

Departmental Committees:

General Curriculum

Graduate Studies Committee

Facilities and Services Committee

Seminar Committee (Chairman)

Promotions and Appointments Committee

Medical School Committees:

Phase I Promotion and Review Board for Inteflex

Medical School Summer Research Committee

University Committees:

Choosing Rackham Fellows

Additional Activities:

October 1980 Participant in NATO Conference on Cell Growth in Erice, Sicily

1981 Paris meeting on Cell Growth, hosted by University of Paris

1987 European Cell Cycle Workshop, Bath, England

1987 EMBO meeting on Bacterial Cell Cycle, Segovia, Spain

1989 Ad hoc meeting on Bacterial Growth, Wageningen, Netherlands

1992 EMBO meeting on Bacterial Cell Surface, April 1992, Palma, Majorca, Spain.

Over many years seminars have been given in Cambridge (GB), Jena, Leicester, Geneva, Basle, Munich, Berlin, London, Paris, Amsterdam, as well as many cities in the United States

1993 Invited speaker, Escherichia coli Chromosome Meeting Madison, Wisconsin.

1999 Poster Presenter, Gordon Research Conference on "Cancer", Newport, Rhode Island.

2002 Poster Presenter, Cell Cycle Meeting, Cold Spring Harbor

2002. Keynote Speaker, Gene Expression 2002, Nashville

2003. Lecturer, Biological Mathematics Institute Course on the Cell Cycle, Ohio State University, Columbus, Ohio

Editorial functions

1976-78 Editorial Board, Journal of Bacteriology

1997-present Editorial Board, Electronic Journal of Biotechnology

Advisory or Peer Review Committees:

Ad Hoc member of Study Section on Microbial Physiology (NIH) (approximately 1975)

Member of Study Section to Evaluate Proposals for Microbial Substitutes for Animal Models (NIH) (1990)

Reviewed proposals for National Science Foundation and NIH.

Reviewed numerous papers for various Journals such as J. Bacteriology, J. Theoretical Biology, EMBO Journal, Trends in Microbiology, Cell Biology and Toxicology, Research in Microbiology, Mathematical Biology, etc.

Training Activities:

Graduate Students:

Jay Keasling, 1991. Currently Professor of Chemical Engineering, University of California at Berkeley.

Postdoctoral Fellows:

Postdoctoral fellows have included: Dr. Gert Wuesthoff, Dr. Margaret Holmes, Dr. David Beckman, Dr. Martin Weinberger, and Dr. David Gally.

Community Activities

Volunteer Counselor for Washtenaw County Council on Aging (aiding in tax preparation).

Board of Directors, The Mamas & the Puppets, a non-profit corporation performing shows regarding environmental protection and science educcation in elementary schools in Southeast Michigan.

The Women's Center of America.  Fund-Raising Committee

Acting, Ann Arbor Civic Theatre (Working, The Dresser, Six Degrees of Separation); Friends of the League (Lend Me a Tenor, Arsenic and Old Lace); Film (The Carrier).
 
 

WEB PAGE: www.umich.edu/~cooper

e-mail: cooper@umich.edu
 

My 27 favorite contributions to science (numbers refer to references below)

1. Discovery of pattern of DNA replication in E. coli (7)
2. Elaboration of the continuum model for eukaryotic cells (22)
3. Explaining how cyclins affect G1-phase length (75)
4. Determination of the bacterial growth law (39)
5. Showing the ideal length/width ratio for motile bacteria is e2/2 (67)
6. Showing both DNA strands segregate non-randomly (20,21)
7. First determination of the molecular size of the E. coli genome (8)
8. Determining the rules for plasmid replication during division cycle (13, 51, 54, 82)
9. Discovery of the heat shock phenomenon in bacteria (18)
10. Identifying a mutant in a heat-shock control protein (19)
11. Explaining G(0) (25, 36, 74)
12. Showing that RNA bacteriophage does not involve a DNA intermediate (1)
13. Showing that non-coat protein synthesis is required for RNA virus replication (2)
14. Finding RNA dependent RNA polymerase in RNA virus infected cells (3)
15. Discovery of the D-methionine utilization pathway (6)
16. Showing Rb protein is not a G1-phase phosphorylated protein (78, 79)
17. Describing an alternative view of Caulobacter development (48)
18. Explaining curvature in Vibrio cholerae (92)
19. Showing yeast grows exponentially during division cycle (71)
20. Determining mathematical formula describing growth of bacterial surface (37, 40, 50)
21. Identifying cAMP binding protein in Dictyostelium (24, 29)
22. First reconstitution of cAMP binding protein and kinase from Dictyostelium (30)
23. Demonstrate single strand insertion during peptidoglycan growth (41)
24. Isolating temperature-sensitive non-sense mutations (16)
25. Explaining length overshoot during shift-up (44)
26. Explaining interdivision time variation in eukaryotes (27)
27. Explaining how cell size is determined at S phase initiation (100)


BIBLIOGRAPHY

Completed Articles in Scientific Journals:

  1. Cooper, S., and N. D. Zinder 1962. The growth of an RNA bacteriophage: the role of DNA synthesis. Virology 18:405-411.
  2. Cooper, S., and N. D. Zinder 1963. The growth of an RNA bacteriophage: the role of protein synthesis. Virology 20:605-612.
  3. August, J. T., S. Cooper, L. Shapiro and N. D. Zinder 1963. RNA phage induced RNA polymerase. Cold Spring Harbor Symp. Quant. Biol. 28:95-97.
  4. Zinder, N. D. and S. Cooper 1964. Host-dependent mutants of the bacteriophage f2. I. Isolation and Preliminary Classification. Virology 23:152-158.
  5. Lodish, H. F., S. Cooper and N. D. Zinder 1964. Host-dependent mutants of the bacteriophage f2. IV. On the biosynthesis of viral RNA polymerase. Virology 24:60-70.
  6. Cooper, S. 1966. Utilization of D-methionine by Escherichia coli. J. Bacteriol. 92:328-332.
  7. Helmstetter, C. E. and S. Cooper 1968. DNA synthesis during the division cycle of rapidly growing Escherichia coli B/r. J. Mol. Biol. 31:507-518.
  8. Cooper, S. and C. E. Helmstetter 1968. Chromosome replication and the division cycle of Escherichia coli B/r. J. Mol. Biol. 31:519-540.
  9. Helmstetter, C. E., S. Cooper, O. Pierucci and E. Revelas 1968. The bacterial life sequence. Cold Spring Harbor Symp. Quant. Biol. 33:809-822.
  10. Cooper, S. 1969. Cell division and DNA replication following a shift to a richer medium. J. Mol. Biol. 43:1-11.
  11. Cooper, S. 1970. A model for the determination of growth rate. J. Theoret. Biol. 28:151-154.
  12. Cooper, S. and G. Wuesthoff 1971. Comment on the use of chloramphenicol to study the initiation of deoxyribonucleic acid synthesis. J. Bact. 106:709-711.
  13. Cooper, S. 1972. Relationship of flac replication and chromosome replication. Proc. Natl. Acad. Sci. U.S.A. 69:2706-2710.
  14. Margolis, S. C., and S. Cooper 1971. Simulation of bacterial growth, cell division, and DNA synthesis. Computers and Biomedical Research 8:427-443.
  15. Cooper, S. and T. Ruettinger 1973. Replication of deoxyribonucleic acid during the division cycle of Salmonella typhimurium. J. Bact. 111:966-973.
  16. Beckman, D. and S. Cooper 1973. Temperature-sensitive nonsense mutations in essential genes of Escherichia coli. J. Bact. 116:1336-1342.
  17. Cooper, S. 1974. On a criterion for using chloramphenicol to define different processes in the initiation of DNA synthesis in bacteria. J. Theor. Biol. 46:117-127.
  18. Cooper, S. and T. Ruettinger 1975. Temperature dependent alteration in bacterial protein composition. Biochem. Biophys. Res. Comm. 62:584-586.
  19. Cooper, S. and T. Ruettinger 1975. Temperature sensitive synthesis of a major protein in a TSN mutant of Escherichia coli. Mol. Gen. Genet. 139:167-176.
  20. Cooper, S. and M. Weinberger 1977. Medium dependent variation of deoxyribonucleic acid segregation, in Escherichia coli. J. Bact. 130:118-127.
  21. Cooper, S., M. Schwimmer and S. Scanlon 1978. Probabilistic behavior of DNA segregation in Escherichia coli. J. Bact. 124:60-65.
  22. Cooper, S. 1979. A unifying model for the G1 period in prokaryotes and eukaryotes. Nature  280:17-19.
  23. Dery, C., S. Cooper, M. A. Savageau and S. Scanlon 1979. Identification and characterization of the camp binding proteins of yeast by photoaffinity labeling. Biochem. Biophys. Res. Comm. 90:993-939.
  24. Cooper, S., D. A. Chambers and S. Scanlon 1980. Identification and characerization of the adenosine 3':5'-cyclic monophosphate binding proteins appearing during the development of Dictyostelium discoideum. Biochem. Biophys. Acta. 629:235-242.
  25. Cooper, S. 1981. The continuum model: application to G1-arrest and G(O), in "Cell Growth", C. Nicolini, ed., Plenum Press. pp. 315-336.
  26. Cooper, S. 1981. The central dogma of cell biology. Cell Biol. Int. Rep. 5:539-551.
  27. Cooper, S. 1982. The continuum model: statistical implications. J. Theor. Biol. 94:783-803.
  28. Guiguet, M. and S. Cooper 1982. A critique of the use of DNA synthesis as a measure of the effect of mitogens on lymphocytes. Biosci. Rep. 2:91-98.
  29. Cooper, S., S. Scanlon and A. Ferguson 1983. Degradation of a cAMP binding protein of Dictyostelium discoideum by an endogenous protease. FEMS Microbiology Letters 18:93-97.
  30. Cooper, S., K. Dasen, M. Lawton and A. Ferguson 1983. Reconstitution of a cAMP-dependent protein kinase from Dictyostelium discoideum. Biochem. Biophys. Acta. 746:120-123.
  31. Cooper, S. 1984 Application of the continuum model to the clock model of the division cycle. In the Cell Cycle Clocks. L. N. Edmunds (ed.), pp. 209-218. Marcel Dekker, NY.
  32. Cooper, S. 1984 The continuum model as a unified description of the division cycle of eukaryotes and prokaryotes. In the Microbial Cell Cycle. P. Nurse and E. Streiblova (eds), pp. 7-18. CRC Press, Boca Raton, FL.
  33. Cooper, S. and N. Metzger 1986. Efficient and quantitative incorporation of diaminopimelic acid into the cell wall of Salmonella typhimurium. FEMS Microbiol. Letters. 36:191-194.
  34. Cooper, S. 1987. Cell cycle controls in higher eukaryotic cells: A reply J. Theor. Biol. 127:247-249.
  35. Cooper, S. 1987 Where and when is peptidoglycan synthesized during the division cycle of Salmonella typhimurium and Escherichia coli. In: Proceedings of the ASM Conference on Antibi Bacterial Cell Wall Synthesis and Assembly. pp79-90. P. Actor, L. Daneo-Mooore, M. L. Higgins, M. R. J. Salton, and G. D. Shockman, eds. ASM, Washington, DC 20006.
  36. Cooper, S. 1987. G(0) and Cell Cycle Controls. Bioessays 7:220-223.
  37. Cooper, S. 1988. Rate and topography of cell wall synthesis during the division cycle of Salmonella typhimurium. J. Bact. 170:422-430.
  38. Cooper, S. 1988. Leucine uptake and protein synthesis are exponential during the division cycle of Escherichia coli B/r. J. Bact. 170:436-438.
  39. Cooper, S. 1988. What is the bacterial growth law during the division cycle? J. Bacteriol. 170:5001-5005.
  40. Cooper, S. and M. L. Hsieh 1988. The use of N-acetylglucosamine to study the rate and topography of peptidoglycan synthesis during the division cycle of Escherichia coli. J. Gen. Microbiol. 134:1717-1721.
  41. Cooper, S., M. L. Hsieh and B. Guenther 1988. The mode of cell wall synthesis in Salmonella typhimurium: Single strand insertion. J. Bacteriol. 170:3509-3512.
  42. Cooper, S. 1989. The continumum model and c-myc regulation. J. Theor. Biol. 135:393-400.
  43. Okuda, A., and S. Cooper 1989. The continuum model: an experimental and theoretical challenge to the G1-model of cell cycle regulation. Experimental Cell Res. 185:1-7.
  44. Cooper, S. 1989. The constrained hoop: An explanation of the overshoot in cell length during a shift up of Escherichia coli. J. Bacteriol. 171:5239-5243.
  45. Cooper, S. 1990. Comparison of backwards and forwards methods of cell cycle analysis. FEMS Microbiol. Lett. 66:1-4.
  46. Cooper S. 1990. The Escherichia coli cell cycle. Res. Microbiol. 141:17-29.
  47. Cooper, S. 1990. The relationship of the acceptor-donor radioactivity ratio and cross-linking in bacterial peptidoglycan: application to surface growth during the division cycle. J. Bacteriol. 172:5506-5510.
  48. Cooper, S. 1990. An alternative view of the Caulobacter crescentus division cycle pattern with application to cell differentiation and cell-cycle-specific synthesis. Proc. R. Soc. Lond. B. 242:197-200.
  49. Cooper, S. 1991. Conjectures on the mathematics of the Division Cycle: Regulation of cell cycles in bacteria and animal cells. In Arino, Axelrod, and Kimmel, eds., Proceedings of the 2nd international Conference on Mathematical Population Dynamics. Marcel Dekker, Inc. pp. 539-546.
  50. Cooper, S. 1991. Synthesis of the cell surface during the division cycle of rod-shaped, Gram-Negative Bacteria. Microbiol. Rev. 55:649-674.
  51. Keasling, J., Palsson, B. O., and Cooper, S. 1991. Cell-cycle-specific F plasmid replication: Regulation by cell size control of initiation J. Bacteriol. 173:2673-2680.
  52. Keasling, J. D., Palsson, B. O. and Cooper, S. 1992. Replication of the R6K plasmid during the Escherichia coli cell cycle. J. Bacteriol. 174:1060-1062.
  53. Cooper, S., 1992. Relationship between the acceptor/donor radioactivity ratio and cross-linking in bacterial peptidoglycan: application to surface synthesis during the division cycle. J. Bacteriol. 172:5506-5510.
  54. Keasling, J. D., B. O. Palsson, and S. Cooper 1992. Replication of Prophage P1 is Cell-Cycle-Specific. J. Bacteriol. 174:4457-4462.
  55. Keasling, J. D., B. O. Palsson, and S. Cooper 1992. Replication of mini-F plasmids during the bacterial division cycle. Res. Microbiol. 143:541-548.
  56. Cooper, S., Gally, D., Suneoka, Y., Penwell, M., Caldwell, K., and Bray, K. 1993. Peptidoglycan synthesis in Salmonella typhimurium. in Bacterial Growth and Lysis, Metabolism and Structure of the Bacterial Sacculus. Plenum Publishing Co., New York.pp. 161-168.
  57. Gally, D. and Cooper, S. 1993. Peptidoglycan Synthesis in Salmonella typhimurium 2616 J. Gen. Microbiol. 139:1469-1476.
  58. Gally, D., Bray, K., and Cooper, S. 1993. Synthesis of Peptidoglycan and Membrane During the Division Cycle of Rod-shaped, Gram-negative Bacteria, J. Bacteriol. 175:3121-3130.
  59. Licht, J., Gally, D., Henderson, T., Young, K., and Cooper, S. 1993.Effect of Mecillinam On Peptidoglycan Synthesis During the Division Cycle of Salmonella typhimurium 2616. Res. Microbiol. 144:423-433
  60. Cooper, S., 1993. The Origin and Meaning of the Schaechter-Maaløe-Kjeldgaard Experiments. J. Gen. Microbiol. 139:1117-1124.
  61. Cooper, S., 1994. Analysis of the Bacterial Division Cycle using Membrane-Elution Method, in Methods in Molecular Genetics, (K. Adolph, ed.) Academic Press, 234-257
  62. Keasling, J., and Cooper, S., 1994. Plasmid Replication During the Bacterial Division Cycle, in Methods in Molecular Genetics, (K. Adolph, ed.) Academic Press, 380-388
  63. Hupp, T., Keasling, J., Cooper, S., and Kaguni, J. 1994. Synthesis of DnaK protein during the division cycle of Escherichia coli. Res. Microbiol. 145:99-100.
  64. Cooper, S., 1995. Bacterial Growth and Division, In Molecular Biology and Biotechnology, R. A. Meyers, editor, VCH Press. pp 57-65.
  65. Cooper, S. 1996. Segregation of Cell Surface Structures, an invited Chapter In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C., 2nd edition.
  66. Cooper, S., 1996. Bacterial Growth and Division, In Encyclopedia of Molecular Biology and Molecular Medicine, R. A. Meyers, editor, VCH Press. pp. 95-103
  67. Cooper, S. and Denny, M. W. 1997. A conjecture on the relationship of bacterial shape to motility in rod-shaped bacteria. FEMS Microbiology Letters. 148:227-231.
  68. Cooper, S. 1997. Division Pattern of a Round Mutant of Escherichia coli. J. Bacteriol. 179:5582-5584.
  69. Cooper, S. 1997. Does the Initiation Mass for DNA Replication in Escherichia coli vary with Growth Rate? Molecular Microbiology. 26:1138-1141.
  70. Cooper, S. 1997. G1 and S Phase Gene Expression Cannot be Analyzed in Mammalian Cells Synchronized by Inhibition. Microb. and Comp. Genomics. 2:269-273.
  71. Cooper, S.; 1997. DNA Replication: the 30th Anniversary of the Bacterial Model and the "Baby Machine". TIBS; 22:490-494.
  72. Cooper, S. 1998. Length Extension in Growing Yeast: Is Growth Exponential? Yes. Microbiology. 144:263-266.
  73. Cooper, S.; 1998. On the proposal on a G0 phase and the Restriction Point. FASEB J. 12:367-373.
  74. Cooper, S.; 1998. On the Interpretation of the Shortening of the G1-phase by Overexpression of Cyclins in Mammalian Cells.    Exp. Cell Res. 238:110-115 .
  75. Cooper, S.; 1998. Mammalian Cells are Not Synchronized in G1 Phase by Starvation or Inhibition: Considerations of the Fundamental Concept of G1-phase Synchronization. Cell Prolif. 31:9-16.
  76. Cooper, S. and Keasling, J. D. 1998. Cycle-specific Replication of Chromosomal and F-plasmid Origins.  FEMS Micro. Lett. 163:217-222
  77. Cooper, S. 1999. Bacterial Reproduction and Growth. invited contribution to the Encyclopedia of Life Sciences. MacMillan Reference Ltd, London..
  78. Cooper S.; 1999. The Continuum Model and G1-Control of the Mammalian Cell Cycle. in progress in Cell Cycle Research. Vol. 4. Chapter 3 (L. Meijer, S. Guidet, and M. Philippe, eds.)   Plenum Press, NYC. 27-39.
  79. Cooper S., Yu, C. and Shayman, J.A. 1999. Phosphorylation-Dephosphorylation of Retinoblastoma Protein is Not Necessary for Passage Through the Mammalian Division Cycle. IUBMB-Life. 48:225-230.
  80. Cooper, S. 2000. Toward a Standard System for the Mammalian Cycle. ASM News66:71-75 (copyrighted by the American Society for Microbiology and reprinted by permission of ASM News).
  81. Cooper, S. 2001 Helical Growth and the Shape of Vibrio Cholerae. FEMS Letters. 198:123-124.
  82. Cooper, S., and Shayman, J.A. 2001. Revisiting Retinoblasoma Phosphorylation during the Mammalian Cell Cycle.     Cellular and Molecular Life Sciences  58:580-595.
  83. Cooper, S.  2001.  Revisiting the Relationship of the Mammalian G1 Phase to Cell Differentiation.  J. Theor. Biol.  208:399-402.
  84. Cooper, S. 2001. Size, Volume, Length and the Control of the Bacterial Division Cycle.  Microbiology.  Microbiology 147: 2629-2630; also page 2632.
  85. Shedden, K. and  Cooper, S. 2002.  Analysis of Cell-Cycle-Specific Gene Expression in Human Cells as Determined by Microarrays.  Proc. Natl. Acad.Sci. USA  99:4379-4384.
  86. Cooper, S. 2002.  Reappraisal of G1-phase arrest and synchronization by lovastatin.  Cell Biol. Int.  27:715-727.
  87. Cooper, S. 2002. Minimally Disturbed, Multi-Cycle, and Reproducible Synchrony using a Eukaryotic "Baby Machine"    Bioessays. 24:499-501
  88. Cooper, S. 2002. The Schaechter-Bentzon-Maaløe experiment and the analysis of cell cycle events in eukaryotic cells. Trends in Microbiology. 10:169-173. (reprinted with permission from Elsevier Science.  The Home page of  Trends in Microbiology is http://www.elsevier.com/locate/tim .  Single copies of the article can be downloaded and printed for the reader's personal rsearch and study.
  89. Shedden, K. and Cooper, S. 2002.  Analysis of Cell-Cycle Gene Expression in S. cerevisiae Using Microarrays and Multiple Synchronization Methods. Nucleic Acids Research.  30: 2920-2929
  90. Cooper, S. 2002.  Cell cycle analysis and microarrays , Trends in Genetics.  18:289-290
  91. Cooper, S. 2002. Cell Biology Moves Forward in 2050. ASM News. 68:260-261.
  92. Cooper, S.  2003.  Rethinking synchronization of mammalian cells for cell cycle analysis.Accepted for publication,Cellular and Molecular Life Sciences
  93. Cooper, S. 2003. Reappraisal of Serum Starvation, the Restriction Point, G0, and G1-phase Arrest Points. FASEB J. 17:333-340
  94. Cooper, S. 2004 Bacterial Growth and Division. Article in Encyclopedia of Molecular Cell Biology and Molecular Medicine.  Wiley-VCH.  In Press.
  95. Cooper, S.  2003.  On the Persistence of Forcing Synchronization Methodology  in preparation.
  96. Cooper, S. 2003 How the change from FLM to FACS affected our understanding of the G1 phase of the cell cycle.  Cell Cycle.  2:157-159
  97. Cooper, S. and Keasling, J. D. 2003. Experimental and theoretical considerations of P1-plasmid replication and segregation during the E. coli cell cycle.  J. Theor. Biol. Submitted.
  98. Cooper, S. 2003.  On the persistence of forcing synchronization methodology.  in preparation
  99. Cooper, S. and Shedden, K. 2003. Microarray Analysis of Gene Expression during the Cell Cycle.  Cell & Chromosome 2:1
  100. Cooper, S. 2003. Control of mammalian cell size and cell size maintenance: Analysis of the model of Conlon and Raff, exponential and linear growth, checkpoints, and control of the mammalian cell cycle. Cell Biol. Int.  Submitted for publication.
  101. Cooper, S. The Continuum Model: Regulation of the mammalian cell cycle is related to a continuous accumulation process and not dependent on phase-specific cascades of gene expression. Mathematical Biosciences Institute Workshop, Ohio State University, Columbus, Ohio. September 29-October 3, 2003.
  102. Cooper, S. 2003.  The Ideas of Ludwik Fleck and Their Application to the Eukaryotic Cell Cycle, the Restriction Point, and G1-phase Control  In Preparation.
  103. Cooper, S.  2004.  Is Whole-Culture Synchronization Biology's "Perpetual Motion Machine"?   Trends in Biotechnology. Accepted for publication
  104. Cooper, S. 2004. The Continuum Model of the Eukaryotic Cell Cycle: Application to G1-phase control, Rb phosphorylation, Microarray Analysis of Gene Expression, and Cell Synchronization. Clinical Oncology. In Press.
  105. Cooper, S. 2004. Whole-culture Synchronization Can Not, and Does Not, Synchronize Cells. Trends in Biotechnology.  In press.
  106. Cooper, S. 2004. Reanalysis of the protocol for in vitro synchronization of mammalian astrocytic cultures by serum deprivation. Brain Research Protocols.  In Press.
  107. Cooper, S. 2004. Control of mammalian cell size and cell size maintenance: Analysis of the model of Conlon and Raff, exponential and linear growth, checkpoints, and control of the mammalian cell cycle. Theoretical Biology and Molecular Modeling  Submitted for publication.
  108. Cooper, S. 2004.  On the persistence of Whole-Culture Synchronization for cell-cycle analysis.  in preparation

    109.  

     
     
     
     
     

  109. Cooper, S.  2004.  The Continuum Manifesto.  Manuscript in Preparation.
Books: Cooper, S. Bacterial Growth and Division, Biochemistry and Regulation of prokaryotic and Eukaryotic Division cycles, Academic press. 1991.

Cooper, S and Keasling, J. D. 2001. Cell Growth and Division In preparation. to be Published by Academic Press.

 Abstracts: Cooper, S. On the existence of a histidine containing protein required for RNA bacteriophage synthesis. Abstracts of the Biophysical Society, 1963.

Helmstetter, C., and S. Cooper. Rate of DNA synthesis during the division cycle of rapidly growing Escherichia coli B/r. Abstracts of Bacteriological Proceedings of Amer. Soc. for Microbiology, 1967.

Cooper, S. and C. Helmstetter. A model for the synthesis of the genome of Escherichia coli B/r growing at different rates. Abstracts of Bacteriological Proceedings of Amer. Soc. for Microbiology, 1967.

Weinberger, M. and S. Cooper. Segregation of DNA in E. coli B/r. Abstracts of American Society for Microbiology, 1976.

Cooper, S., M. Schwimmer and S. Scanlon. Evidence for the equivalence of both strands during non-random segregation of DNA in Escherichia coli B/rK. Abstracts of American Society for Microbiology, 1977.

Cooper, S., D.A. Chambers, S. Scanlon and J.B. Respess. Detection of developmentally regulated cAMP binding proteins in Dictyostelium discoideum by photoaffinity labeling. Abstracts of the XIth International Congress of Biochemistry, Toronto, Canada, p. 509, 1979.

Cooper, S. An alternative view of the G(0) and G1-arrest phases of the eucaryotic cell cycle. Abstract of 9th annual ICN-UCLA symposia; control of cellular division and development. At Keystone, Colorado. Published in J. of Supramol. Struc., Supp. 4, p. 155, 1980.

Cooper, S. The rate and topography of cell wall synthesis during the division cycle of Salmonella typhimurium. Presented at the ASM Meeting on Antibiotic Inhibition and the Structure of Bacterial Cell Walls, Philadelphia, PA, May, 1987.

Cooper, S. The Continuum Model: A Unified Explanation of the G1-period and G(0) States of Animal and Bacterial Cells. Presented at the Eighth European Cell Cycle Workshop, Bath, England. September 1987.

Cooper, S. The rate and topography of cell wall synthesis during the division cycle of Salmonella typhimurium. Presented at the Eighth European Cell Cycle Workshop, Bath, England. September 1987.

Cooper, S. The rate and topography of cell wall synthesis during the division cycle of Salmonella typhimurium. Presented at the EMBO Conference on Bacterial Growth and Duplication, Segovia, Spain, October, 1987.

Cooper, S. Determination and maintenance of cell shape of rod-shaped Gram negative bacteria American Society for Microbiology Anaheim, CA 1990.

Keasling, J. and Cooper, S. Cell-cycle-specific F plasmid replication during the Escherichia coli division cycle: Regulation of replication by cell size control of initiation 1990. EMBO Workshop on the Bacterial Cell Cycle, Structural and Molecular Aspects, Collonges-La-Rouge, France, October 1990.

Keasling, J. and Cooper, S. Cell-cycle-specific F plasmid replication during the Escherichia coli division cycle: Regulation of replication by cell size control of initiation 1990. Annual Meeting of the American Institute of Chemical Engineers, Chicago, IL November 1990.

Keasling, J. and Cooper, S. Cell-cycle-Speciificity, Regulation by cell size control of initiation, and the relationship of different origins of replication to plasmid synthesis. American Society for Microbiology, Dallas TX, 1991. May 1991.

Cooper, S. and J. D. Keasling, F Plasmid replication: cell-cycle specificity, regulation by cell size control of initiation, and the relationship of different origins of replication to plasmid synthesis. Presented at Human Frontier Science Program Workshop on Regulatory Mechanisms of DNA replication in Les Arcs France. March 1991.

Cooper, S. and J. D. Keasling, Synthesis and regulation of cytoplasm, DNA, cell surface, and plasmid synthesis during the bacterial division cycle. Cold Spring Harbor Symp. Quant Biol. 1991 Annual Meeting. May-June, 1991.

Cooper, S. and J. D. Keasling, Cell-cycle-specific F plasmid replication during the Escherichia coli division cycle: Regulation of replication by cell size control of initiation.To be presented at Gordon Conference on Extrachromosomal Elements, July, 1991.

Keasling, J. and Cooper, S. Dynamics and Control of Bacterial Plasmid Replication. AIChE National Meeting, Los Angeles, CA. 1991.

Keasling, J. and Cooper, S. Plasmid replication during the division cycle. Keystone Symposium on Molecular Mechanisms in DNA Replication and Recombination, Taos, NM. 1992.

Cooper, S., David Gally, Yuko Suneoka, Melissa Penwell, Kelly Caldwell, and Kelvin Bray. Synthesis of Peptidoglycan in Salmonella typhimurium. Presented at the FEMS Conference on Bacterial Growth and Lysis, Lluc, Mallorca, Spain, April 5-10, 1992.

Cooper, S., Michelle Hoefer, Sujatha Singaracharlu, Kelvin Bray, and Dylan Clyne. Replication of low-copy plasmids at specific times during the division cycle of Escherichia coli. Presented at the 2nd International E. coli Genome Meeting, Madison Wisconsin. September, 1993.

Cooper, S., and Ma., M. Non-random strand segregation in Escherichia coli and its relationship to cell wall segregation. Presented at the 2nd International E. coli Genome Meeting, Madison Wisconsin. September, 1993.

Cooper, S. The Continuum Model: a reanalysis of the G1-phase and its relationship to the regulation of the division cycle. Presented at the 1998 meeting of the Cell Proliferation Society, Cross Keys, Baltimore. March, 1998.

Cooper, S. Retinoblastoma Phosphorylation During the MammalianDivision Cycle. Presented at the 1999 Gordon Research Conference, Newport, Rhode Island, August, 1999.

Shedden, K. and Cooper, S. Statistical analysis of human cell-cycle-specific gene expression patterns based on microarrays. J. V. Neel Annual Genetics Symposium, University of Michigan, May, 2001.

Shedden, K. and  Cooper, S.  Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization. Cold Spring Harbor Cell Cycle Meeting. May 15-19, 2002.

Cooper, S. Yu, C., and Shayman, J. Phosphorylation-dephosphorylation of retinoblastoma protein is not necessary for passage through the mammalian division cycle.. Cold Spring Harbor Cell Cycle Meeting. May 15-19, 2002.

Cooper, S.  Revisiting G1-phase arrest and synchronization by lovastatin.  Cold Spring Harbor Cell Cycle Meeting. May 15-19, 2002.
 
 

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