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faculty
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Michael
D. Morris
Professor
of Chemistry
Ph.D., Harvard University
Analytical
Laser Spectroscopy and Imaging; Electrophoretic
Separations
Phone: (734) 764-7360
E-mail: mdmorris@umich.edu
Fax: 734-764-8815
Research
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Our
research group applies Raman spectroscopy and spectroscopically
resolved two and three dimensional imaging to chemical
and biomedical problems. It also specializes in
high speed video microscopy. We are interested
in problems at scales ranging from single molecules
to tissue specimens.
We
are leaders in Raman microspectroscopy and microscopic
imaging. We develop new spectroscopic instrumentation
based on modern photonics technology and new
chemometric and other image processing methods
for generation of hyperspectral image contrast.
A core interest is the chemistry that governs
the properties of musculo-skeletal tissues. We
use our unique Raman spectroscopic imaging and
dynamic microspectroscopy capabilities to study
normal and pathological development and failure
mechanisms of these tissues at every stage of
the life cycle from embryo through maturity.
We study how these tissues change over time and
how they respond to the imposition of normal
and traumatic external loads. The work has led
to new insights into the effects of skeletal
birth defects such as craniosynotosis and osteogenesis
imperfecta, into the tissue changes associated
with metababolic diseases such as osteoporosis
and osteoarthritis and into the biomechanics
of bone tissue and cartilage. The same technology
is also applied to characterization of biomaterials
ranging from heart valve replacements to dental
cements. Additionally
we have unique capabilities and facilities for
high frame rate fluorescence imaging at the single
molecule level. The lab has used supra-video
rate imaging to study dynamics of DNA and RNA
electrophoretic migration and to study the statistics
of electrophoretic dynamics.
Our
work is interdisciplinary and requires close collaboration
with biomedical research groups in the medical
and dental schools and in the engineering college.
Uniquely within the chemistry department, we operate
a core Raman spectroscopy facility that brings
graduate students and postdoctoral fellows into
contact with life scientists from across the university
for short and long-term projects.
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AWARDS
- 2005 Mann Award - Federation
of Analytical Chemistry and Spectroscopy Societies
for achievements in applied Raman Spectroscopy
- 2005 Meggers Award - Society
for Applied Spectroscopy
- 2005-06
Margaret and Herman Sokol Faculty Award in
the Sciences
- Fellow
of the American Association for the Advancement
of Science
- Award
in Specrochemical Analysis, American Chemical
Society Division of Analytical Chemistry
- Anachem
Award, Association of Analytical Chemists
- Gold
Medal, Society for Applied Spectroscopy New
York section
- Lester
Strock Award, Society for Applied Spectroscopy
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REPRESENTATIVE PUBLICATIONS
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Smukler, Abigal R.; Crane, Nicole J.; Morris, Michael D.; McHugh, Jonathan B.; Säämänen, Anna-Marja; Vuorio, Eero I., Roessler, Blake J. Raman Spectroscopic Analysis of Femoral Articular Cartilage in Del 1 (+/-) Transgenic Mice, Appl. Spectrosc. 2006, 60 , 366-372.
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Schulmerich, Matthew V.; Finney, William F.; Fredericks, Richard A.; Morris, Michael D. Subsurface Raman Spectroscopy and Mapping using a Globally Illuminated non-Confocal Fiber Optic Array Probe in the Presence of Raman Photon Migration, Appl. Spectrosc. 2006, 60, 109-114.
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Wilson, Erin E; Awonusi, Ayorinde; Morris, Michael D; Kohn,David H; Tecklenburg, Mary MJ; Beck; Larry W. Three Structural Roles for Water in Bone Observed by Solid-State NMR, Biophys. J. 2006 , 90, 3722-3731.
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de Carmejane, O.; Morris, M.D.; Davis, M.K.; Stixrude, L.; Tecklenburg, M.; Rajachar, R. M. , Kohn, D.H., Bone chemical structure response to mechanical stress studied by high pressure Raman spectroscopy, Calcif. Tissue Int. 2005, 76, 207 - 213.
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Crane, Nicole; Morris, Michael D.; Ignelzi Jr., Michael A.; Yu, Gengeng, Early Chemical Changes in FGF2-induced Craniosynostosis, J. Biomed. Optics 2005, 10, 031119.
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