Faculty

		Stephen J. Weiss, M.D. Chief, Molecular Medicine & Genetics Upjohn Professor of Medicine and Oncology 5000 Life Sciences Institute sjweiss@umich.edu 734/764-0030
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Research Interests

The research interests of the Weiss laboratory focus on the mechanisms used by normal and neoplastic cells to remodel the 3-dimensional extracellular matrix during events ranging from cell differentiation and tissue morphogenesis to tumor cell metastasis. Current areas of emphasis include the regulation of the epithelial-mesenchymal cell transformation program by the transcription factor, Snail, and the function of the membrane-type matrix metalloproteinases during development and neoplasia.

Education

1966-1970 Eastmoor High School, Columbus, Ohio

1970-1973 Undergraduate, Ohio State University, B.A., (Biological Sciences/Biochemistry)

1973-1977 Graduate/Professional, Ohio State University, College of Medicine, M.D.

Postgraduate Training

1977-1978 Resident, Washington University, Department of Pathology, Barnes Hospital, St. Louis, Missouri

1978-1980 Research Fellow, The University of Michigan Medical Center, Division of Hematology and Oncology, Ann Arbor, Michigan

Honors and Awards

1976 Landacre Research Award

1977 Landacre Research Award

1977 College of Medicine Award

1977 Department of Medicine Award

1977 Upjohn Achievement Award

1982 Jerome W. Conn Clinical Investigator Award for Excellence in Clinical Research

1983 Central Society for Clinical Research

1984 American Society for Clinical Investigation

1985 Central Clinical Research Club

1986-1991 Editorial Committee of the American Society for Clinical Investigation

1991 Association of American Physicians

1991-present E. Gifford and Love Barnett Upjohn Chair

1993 Young Investigator Award (National) American Federation for Clinical Research

1993-2003 NIH MERIT Award

1997-2002 Editor-in-Chief, Journal of Clinical Investigation

2001-present Institute of Medicine, National Academy of Sciences

Recent Publications

Hotary, K.B., Yana, I., Sabeh, F., Li, X-Y, Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., Hiraoka, N., Weiss, S.J. Matrix metalloproteinases regulate fibrin-invasive activity via MT1-MMP-dependent and independent processes. Journal of Experimental Medicine 2002, 195:295-308.

Hotary, K.B., Allen, E.D., Brooks, P.C., Datta, N.S., Long, M.W., Weiss, S.J. 2003. Membrane type-1 matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell 114:33-45

Filippov, S., Caras, I., Murray, R., Matrisian, L.M., Chapman, Jr., H.A., Shapiro, S., Weiss, S.J. 2003. Matrilysin-dependent elastolysis by human macrophages. J. Exp. Med. 198:925-935.

Chun, T-H., Sabeh, F., Ota, I., Murphy, H., McDonagh, K., Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., and Weiss, S.J. MT1-MMP-dependent neovessel formation within the confines of the 3-dimensional extracellular matrix. Journal of Cell Biology 2004, 167:757-767.

Sabeh, F., Ota, I., Holmbeck, K., Birkendal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C. Shapiro, S., Inada, M., Krane, S., Allen, E., Chung, D., and Weiss, S.J. Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase, MT1-MMP. Journal of Cell Biology 2004, 167:769-781.

Lehti, K., Allen, E., Birkedal-Hansen, H., Holmbeck, K., Miyake, Y., Chun, T.-H., Weiss, S.J., An MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculature. Genes & Development 2005, 19:979-991.

Filippov, S., Koenig, G.C., Chun, T.H., Hotary, K.B., Ota, I. Bugge, T.H., Roberts, J.D., Fay, W. P., Birkedal-Hansen, H., Holmbeck, K., Sabeh, F., Allen, E.D., Weiss, S.J. MT1-Matrix Metalloproteinase Diects Arterial Wall Invasion and Neointima Formation by Vascular Smooth Muscle Cells. Journal of Experimntal Medicine 2005, 202:663-671.

Chun, T.H., Hotary, K.B., Sabeh, F., Saltiel, A.R., Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., Weiss, S.J. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 2006, 125:577-591.

Hotary, K., Li, X.Y., Allen, E., Stevens, S.L., and Weiss, S.J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes & Development 20:2673-2686, 2006.

Yook, J.I., Li, X.Y., Ota, I., Hu, C., Kim, H.S., Kim, N.H., cha, S.Y., Ryu, J.K., Choi, Y.J., Kim, J., Fearon, E.R., and Weiss, S.A. A Wnt/Asin2/GSK3b cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biology 8:1398-1406, 2006.

Yana, I., Sagara, H., Takaki, S., Takatsu, K., Nakamura, K., Nakao, K., Katsuki, M., Taniguchi, S., Aoki, T., Sato, H., Weiss, S.J., and Seiki, M. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. Journal of Cell Science. 2007, 120:1607-1614.

Zhai, Y., Hotary, K.B., Nan, B., Bosch, F.X., Munoz, N., Weiss, S.J., and Cho, K.R. Gene expression analysis of pre-invasive and invasive cervical squamous cell carcinomas. Cancer Research 2007, in press.

Lab Projects

CVs from interested candidates may be forwarded to sjweiss@umich.edu

Additional Lab Links

Cellular and Molecular Biology Program

Lab Members

Tae-Hwa Chun, M.D., Ph.D.

Casey Hu, M..D.

Xiao-Yan Li, Ph.D.

Rui Liu, Ph.D.

Xuwen Liu, Ph.D.

Grant Rowe, M.S.T.P.

Farideh Sabeh, Ph.D.

Jong-In Yook, M.D., Ph.D.