Stan Watson M.D.,Ph.D.
| 2060 Mental Health Research Institute 0720 |
| Ann Arbor, MI 48109 |
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This laboratory studies neurotransmitter systems in their anatomical context and from the point of view of regulatory biology, especially in stress depression and drug abuse. A particular focus is to describe the changes in biosynthetic capacity of neuronal circuits by quantitating the messenger RNA in situ along with the rich and complex area of 5HT, DA and opiate receptor molecular genetics. In addition the laboratory has a full range of biochemical and molecular biology tools and anatomical techniques include track tracing, thymidine autoradiography and standard lesioning methods. Finally, we are interested in the biological basis of depression and is actively involved in designing human clinical studies in depressed patients using various challenges in collaboration with Dr. Akil.
Lopez-Figueroa, M.O., Day, H.E.W., Lee, S., Rivier, C., Akil, H. and Watson, S.J.: Temporal and anatomical distribution of nitric oxide synthase mRNA expression and nitric oxide production during central nervous system inflammation. J. Brain Res. 852:239-246, 2000, on web (www1.elsevier.com/locate/bres) 11/1/99.
Neal, C.R., Mansour, A.,Reinscheid, R., Nothacker, H.-P., Civelli, O. and Watson, S.J.: Localization of orphan FQ (nociceptin) peptide and messenger RNA in rat central nervous system. J. Comp. Neurology 406:503-547, 1999.
Watson, S.J. and Akil, H.: Gene chips and arrays revealed: A primer on their power and their uses. Biol. Psychiatry 45:533-543, 1999.
Wilson, B.D., Bagnol, D., Kaelin, C.B., Ollmann, M.M., Gantz, I., Watson, S.J. and Barsh, G.S.: Physiologic and anatomic circuitry between Agouti-related protein and leptin signaling. Endocrinology 140(5):2387-2397, 1999.
Richardson-Burns, S.M., Haroutunian, V., Davis, K.L., Watson, S.J., Meador-Woodruff, J.H.: Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus. Biological Psychiatry. 47:22-8, 2000
Lu, X.Y., Bagnol, D., Burke, S., Akil, H., Watson, S.J.: Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Hormones & Behavior. 37:335-44, 2000
Devine, D.P., Watson, S.J., Akil, H.: Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis. Neuroscience. 102:541-53, 2001
He, L., Gunn, T.M., Bouley, D.M., Lu, X.Y., Watson, S.J., Schlossman, S.F., Duke-Cohan, J.S., Barsh, G.S.: A biochemical function for attractin in agouti-induced pigmentation and obesity. Nature Genetics. 27:40-7, 2001
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