Yehoash Raphael Ph.D.
| 9220B Medical Science Research Building III 0648 |
| Ann Arbor, MI 48109 |
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Research in this laboratory is aimed at understanding the mechanism of repair and regeneration in the auditory and vestibular epithelium in the inner ear. Experiments in avian ears are designed to characterize precursor cells and signals that mediate repair and production of new hair cells after trauma. Research in mammals is directed at developing gene transfer technology for inner ear application. As genes that play important roles in development, survival, resistance, repair and regeneration of the inner ear are being discovered and characterized, it is important to be able to deliver these genes into cells and fluids of the ear. Viral-mediated gene transfer is one of the more innovative and attractive means for gene transfer. Our experiments are directed at expressing transgenes that may protect inner ear cells from trauma or enhance repair and regeneration following acoustic or ototoxic insults to the ear.
Komeda, M., Roessler, B.J. and Raphael, Y.: The influence of interleukin-1 receptor antagonist transgene on spiral ganglion neurons. Hear. Res. 131, 1-10, 1999.
Kruger, R.P., Goodyear, R.J., Legan, P.K., Warchol, M., Raphael, Y., Cotanche, D.A. and Richardson, G.P.: The supporting cell antigen: a receptor-like protein tyrosine phosphatase expressed in the sensory epithelia of the avian inner ear. J. Neurosci. 19:4815-4827, 1999.
Suzuki, M., Yagi, M., Brown, J.N., Miller, A.L., Miller, J.M., Raphael, Y.: Effect of transgenic GDNF expression on gentamicin-induced cochlear and vestibular toxicity. Gene Therapy. 7:1046-54, 2000
Anderson, D.W., Probst, F.J., Belyantseva, I.A., Fridell, R.A., Beyer, L., Martin, D.M., Wu, D., Kachar, B., Friedman, T.B., Raphael, Y., Camper, S.A.: The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells. Human Molecular Genetics. 9:1729-38, 2000
Raphael, Y., Kobayashi, K.N., Dootz, G.A., Beyer, L.A., Dolan, D.F., Burmeister, M.: Severe vestibular and auditory impairment in three alleles of Ames waltzer (av) mice. Hearing Research. 151:237-249, 2001
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