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Pollution Prevention and Chemistry

Prepared by Kellie DuBay and Jason Schweitzer, NPPC Research Assistants, under the direction of Thomas Dunn, Professor, Department of Chemistry; Gregory A. Keoleian, Assistant Research Scientist, School of Natural Resources and Environment; and Nancy A. Osborn, Publications Manager, NPPC.

Table of Contents

Additions


Using This Compendium

There are many ways to incorporate pollution prevention principles into the field of chemistry -- industrial applications, academic research, educational curricula. These are illustrated in the journal articles, reports, books, conference proceedings, and educational tools cited in this Resource List. We recognize that this list does not identify every source relevant to the topic of pollution prevention in chemistry. But we believe that it will help people get a good start on incorporating pollution prevention into the chemistry curriculum.

In this Resource List, we have grouped all citations under several main themes. Then, to more specifically describe the contents of the citations, we have assigned codes to them. Finally, each citation has a number corresponding to its audience level. (For a description of these themes and codes, see "Classification of Resource Materials" on the page 3.)

At the end of the Resource List is a summary matrix. An alphabetical list of the citations runs down the left side of the matrix. Codes run along the top. The numbers in the cells represent the audience level.

Thus, you may approach this set of resources from any angle. If you want to examine everything within a theme, start with the text of the Resource List. If you would prefer to keep a narrower focus, start with the appropriate column in the matrix -- you will be able to quickly identifiy all citations pertaining to a general topic (e.g., "alternative synthesis"), a specific subject (e.g., "a synthesis employing biological systems"), or a combination (e.g., "alternative biological catalysts" or "toxicity/risk assessments of solvent alternatives").

Complementing the Resource List is our Annotated Bibliography, which describes all Resource List materials in more detail; it is arranged alphabetically by author name. Once you have chosen citations from either the Resource List or its matrix, you may turn to the Annotated Bibliography for a more detailed description. The Resource List, its matrix, and the accompanying Annotated Bibliography are designed to make this compendium easily accessible by a wide range of users.

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Terminology and Framework

When evaluating the content of these documents, it is important to understand that pollution prevention within the chemistry discipline is relatively new, with little uniformity in the use of terminology. Phrases and words such as "benign," "non-toxic," "benign by design," "green chemistry," "environmental chemistry," "safer chemical design," and "clean processes" are often used synonymously to describe very different concepts. Specific criteria for definitions are usually not given, and frameworks for definitions are rarely explicitly stated. This lack of uniform definitions becomes a problem when chemicals or chemical syntheses are evaluated. For example, a certain chemical may be ecologically safe and deemed a "benign" alternative, but the synthesis of that chemical may involve highly toxic intermediates or by-products.

To label a chemical substance or process with a word like "benign," one must consider all aspects of the chemical and its synthesis. A comprehensive examination encompasses all of these issues: material processing, manufacturing, use, material or energy recovery, and disposal. The following framework * defines several important criteria for the design and management of chemical substances and processes.

Of course, few chemicals or processes will be in perfect accord with all of these criteria. Tradeoffs will occur, and the outcome of design and management decisions will depend on how one weights the individual issues. We encourage readers to make their own judgments about the "environmentally preferable" alternatives presented in this compendium based on the above "Life Cycle Design" criteria.

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Classification of Resource Materials

The citations in this Resource List are grouped into five main themes. The citations themselves have been assigned General and Subject codes to further describe the information they cover. Also, in order to give the reader an idea of a citation's complexity, numerical codes indicate each document's intended audience.

MAIN THEMES:

I. Incorporating Pollution Prevention Into Curricula

II. Less-toxic Alternatives in Chemical Syntheses

III. Computer or Mathematical Modeling

IV. Pollution Prevention: Related Programs

V. Overviews or General Discussion

GENERAL CODES

A: Describes a new, more environmentally responsible synthetic route to a product. One example is the substitution of supercritical CO2 for organic solvents when synthesizing polymeric materials; another is the synthesis of polyurethane from the catalytic carbonylation (as opposed to the phosgenation) of nitroaromatic compounds.

B: Describes the replacement of a product with a new, less-toxic alternative. An example is the substitution of isocyanate sealants with acetoacetate-based sealants in the adhesive industry.

C: Presents broader overviews of topics relevant to pollution prevention in chemistry. These documents may provide information on the history, future, and/or recent developments of a chemical synthesis, industrial process, or research program. Often included are general discussions of cost, waste, and toxicity.

SUBJECT CODES

Bio. A synthesis or catalysis employing biological systems (e.g., the synthesis of catechol from a biocatalytic/enzymatic pathway as opposed to benzene alkylation).

Cat. Chemical design incorporating alternative catalysts.

CS An industrial application of pollution prevention principles-a case study providing readers with a demonstration of how P2 principles can be incorporated into industry.

Econ. The economic aspects of chemical production.

EU Assessments of chemical substitutes for end-use applications based on performance, toxicity, and other issues.

F/R Chemical design incorporating alternative feedstocks or reactants.

Opt. Approaches for optimizing a synthetic procedure so that yield is enhanced and/or the generation of harmful by-products is reduced or eliminated.

SAR Mathematical relationships between a chemical's structure and its measurable behaviors. [These documents may address structure-activity relationships or quantitative structure-activity relationships (QSARs).]

Sim. The use of computer modeling or simulation in the development of new synthetic pathways or novel compounds

Sol. Chemical design incorporating alternative solvents.

T/R Toxicity or risk assessment of chemicals.

AUDIENCE LEVEL CODES

1: Requires some elementary science background.

2: Requires undergraduate knowledge of chemistry.

3: Requires advanced knowledge of chemistry (intended audience is most likely to be faculty, industry professionals, degreed chemists).

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Educational Tools

Goller, Edwin J., and John H. Miller. "Microscale Qualitative Analysis." Journal of Chemical Education 70, no. 6 (June 1993): A159-A160.

Reel, Kevin. "Hydrogen Sulfide Is Not Such a Rotten Idea." Journal of Chemical Education 70, no. 10 (October 1993): 854.

Wilcox, Mary F., and Judith G. Koch. "A Freshman Laboratory Program Without Chromium." Journal of Chemical Education 70, no. 6 (June 1993): 488.


Reference Materials

I. Incorporating P2 Into Curricula

Carey, Francis A., and Andrew F. Carey. "Environmentally Benign Synthesis in the Introductory Organic Chemistry Lecture Course." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 180. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994.
[C] [Econ, 2]

Huheey, James E. "Incorporating Environmental Issues Into the Inorganic Chemistry Curriculum." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 181. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Keoleian, Gregory A., and Jonathan W. Bulkley. "Incorporating Pollution Prevention Into the Chemistry Curriculum: New Challenges and Opportunities." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 186. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [1]

Singh, Mono M., Ronald M. Pike, and Zvi Szafran. "Pollution Prevention in the Organic and Inorganic Chemistry Laboratory: Microscale Approach." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 194-197. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [2]

Smith, Leverett R. "Securing Environmental Concerns in the Chemistry Curriculum." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 198-200. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Steinfeld, J. I., and D. S. Bem. "Graduate Research and Training in Chemistry of the Environment at M.I.T." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 187-190. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Szafran, Zvi, Mono M. Singh, and Ronald M. Pike. "The Microscale Inorganic Laboratory: Safety, Economy, and Versatility." Journal of Chemical Education 66, no. 11 (November 1989): A263-A267. [C] [1]

Tully, J. C. "Environmental Education From an Industrial Perspective." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 203. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [CS, 3]

Vellaccio, Frank. "Making a Place for Environmentally Benign Synthesis in the Introductory Chemistry Curriculum: Is it a Moral Imperative?" American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 179. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Zwaard, A. W., H. P. W. Vermeeren, and R. de Gelder. "Safety Education for Chemistry Students: Hazard Control Starting at the Source." Journal of Chemical Education 66, no. 4 (April 1989): A112-A114. [C] [F/R, Cat, T/R, 1]

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II. Less-Toxic Alternatives in Chemical Syntheses

II.A ALTERNATIVES TO PHOSGENE IN INDUSTRIAL SYNTHESES

DePompei, M. F. "Non-Isocyanate Sealants." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 393-394. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994.
[B] [EU, CS, 3]

Gargulak, J., and W. Gladfelter. "Homogeneous Catalytic Carbonylation of Nitroaromatics." Journal of the American Chemical Society 116 (1994): 8933-8495. [A] [Cat, Opt, 3]

Komiya, Kyosuke, Muneaki Aminaka, Kazumi Hasegawa, Hiroshi Hachiya, Hiroshige Okamoto, Shinsuke Fukuoka, Haruyuki Yoneda, Isaburo Fukawa, and Tetsuro Dozono. "New Process for Producing Polycarbonate Without Phosgene and Methylene Chloride." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 343-346. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [F/R, CS, 3]

McGhee, W., Pan Yi, and D. Riley. "Highly Selective Generation of Urethanes from Amines, Carbon Dioxide, and Alkyl Chlorides." Journal of the Chemical Society-London, Chemical Communications (1994) 699-700. [A] [F/R, 3]

McGhee, William D., Mark Pater, Dennis Riley, Ken Ruettimann, John Solodar, and Thomas Waldman. "Generation of Organic Isocyanates From Amines, Carbon Dioxide and Electrophilic Dehydrating Agents: Use of o-Sulfobenzoic Acid Anhydride." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 206-210. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [F/R, 3]

Riley, Dennis, William D. McGhee, and Thomas Waldman. "Generation of Urethanes and Isocyanates from Amines and Carbon Dioxide." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 122-132. Washington: American Chemical Society, 1994. [A] [F/R, CS, 3]

Waldman, T., and W. McGhee "Isocyanates From Primary Amines and Carbon Dioxide: 'Dehydration' of Carbamate Anions." Journal of the Chemical Society-London, Chemical Communications (1994): 957-958. [A] [F/R, CS, 3]

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II.B SUPERCRITICAL CARBON DIOXIDE AS AN ALTERNATIVE SOLVENT

Aresta, Michele. "Perspectives of Utilization of Carbon Dioxide as a Building Block." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 316-319. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994.
[A] [F/R, Cat, 3]

Bradley, David. "Solvents Get the Big Squeeze." New Scientist 143 (6 August 1994): 32-35. [C] [Sol, Cat, 2]

Combes, J. R., Zhibin Guan, and John M. DeSimone. "Homogenous Free-Radical Polymerizations in Carbon Dioxide: Telomerizations of 1,1-Difluoroethylene in Supercritical Carbon Dioxide." Macromolecules 27 (1994): 865-867. [A] [Sol, CS, 2]

DeSimone, J. M., E. E. Maury, Z. Guan, J. R. Combes, Y. Z. Menceloglu, M. R. Clark, J. B. McClain, T. J. Romack, and C. D. Mistele. "Homogeneous and Heterogeneous Polymerization In Environmentally Responsible Carbon Dioxide." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 212-214. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, CS, 3]

DeSimone, John M., Zhibin Guan, and C. S. Eisbernd. "Synthesis of Fluoropolymers in Supercritical Carbon Dioxide." Science 257 (August 14, 1992): 945-947. [A] [Sol, CS, 2]

Donohue, Marc D., and Jennifer L. Geiger. "Reduction of VOC Emission During Spray Painting Operations: A New Process Using Supercritical Carbon Dioxide." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 218-219. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, CS, 3]

"Gassy Plastics." Discover 16, no. 6 (June 1995): 80. [A] [Sol, CS, 1]

Guan, Zhibin, and John M. DeSimone. "Fluorocarbon-Based Heterophase Polymeric Materials: Block Copolymer Surfactants for Carbon Dioxide Applications." Macromolecules 27 (1994): 5527-5532. [A] [Sol, 3]

Johnston, K. P. "Safer Solutions for Chemists." Nature 368 (17 March 1994): 187-188. [A] [Sol, 2]

Lim, P. K. "Environmentally Benign Oil-Water Interfacial Synthesis." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 238. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, Cat, CS, 3]

Sawan, Samuel P., Yeong-Tarng Shieh, and Jan-Hon Su. Evaluation of the Interactions Between Supercritical Carbon Dioxide and Polymeric Materials. Los Alamos National Lab Report #LA-UR-94-2341. Available from the National Technical Information Service, 5285 Port Royal Road, Springfield, VA, 22161, (703) 487-4650 ,or the Office of Scientific and Technological Information, P.O. Box 62, Oakridge, TN, 37831, (615) 576-8401. [C] [Sol, CS, 3]

Tanko, James M., Joseph F. Blackert, and Mitra Sadeghipour. "Supercritical Carbon Dioxide as a Medium for Conducting Free-Radical Reactions." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 98-113. Washington: American Chemical Society, 1994. [A] [Sol, 2]

Tanko, James M., Kamrudin N. Suleman, Glenn A. Hulvey, Anna Park, and Jennifer E. Powers. "Solvent Pressure Effects in Free Radical Reactions: A Selectivity Inversion in Free Radical Brominations Induced by Solvent." Journal of the American Chemical Society 115 (1993): 4520-4526. [A] [Cat, Opt, 3]

Tumas, William, Shaoguang Feng, Richard LeLacheur, David Morgenstern, Paul Williams, Steve Buelow, Carol Burns, Bernard Foy, Michael Mitchell, Mark Burk, and Robert Waymouth. "Chemical and Catalytic Transformations in Supercritical Fluids." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 211. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, Cat, 3]

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II.C D-GLUCOSE AS AN ALTERNATIVE STARTING MATERIAL

Dell, K. A., and J. W. Frost. "Identification and Removal of Impediments to Biocatalytic Synthesis of Aromatics from D-Glucose: Rate-Limiting Enzymes in the Common Pathway of Amino Acid Biosynthesis." Journal of the American Chemical Society 115 (1993): 11581-11589.
[A] [Cat, Opt, 3]

Draths, K. M., and J. W. Frost. "Conversion of D-Glucose into Catechol: The Not-So-Common Pathway of Aromatic Biosynthesis." Journal of the American Chemical Society 113 (1991): 9361-9363. [A] [Cat, Bio, 3]

Draths, Karen M., and John W. Frost. "Environmentally Compatible Synthesis of Adipic Acid from D-Glucose." Journal of the American Chemical Society 116 (1994): 399-400. [A] [F/R, Cat, Bio, 3]

Draths, Karen M., and John W. Frost. "Microbial Biocatalysis: Synthesis of Adipic Acid from D-Glucose." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 32-45. Washington: American Chemical Society, 1994. [A] [F/R, Cat, Bio, Econ, 3]

Draths, Karen M., D. L. Pompliano, D. L. Conley, J. W. Frost, A. Berry, G. L. Disbrow, R. J. Staversky, and J. C. Lievense. "Biocatalytic Synthesis of Aromatics from D-Glucose: The Role of Transketolase." Journal of the American Chemical Society 114 (1992): 3956-3962. [A] [Opt, Bio, 3]

Draths, K. M., T. L. Ward, and J. W. Frost. "Biocatalysis and Nineteenth-Century Organic Chemistry: Conversion of D-Glucose Into Quinoid Organics." Journal of the American Chemical Society 114 (1992): 9275-9276. [B] [F/R, Bio, 2]

Emsley, John. "A Cleaner Way to Make Nylon." New Scientist 141 (12 March 1994): 15. [A] [F/R, Bio, CS, 3]

Frost, John W., and Jeff Lievense. "Prospects for Biocatalytic Synthesis of Aromatics in the 21st Century." New Journal of Chemistry 18 (1994): 341-348. [A] [F/R, Cat, Bio, CS, Econ, 2]

Frost, John. "Green Chemistry at Work: Products Can Be Made From Glucose Instead of Benzene." EPA Journal 20, no. 3 (Fall 1994): 22-23. [A] [F/R, Cat, Bio, 1]

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II.D BIOCATALYSIS OR BIOLOGICAL REAGENTS

Anders, M. W. "Designing Safer Chemicals: Role of Bioactivation in Chemical Toxicity." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 366-368. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994.
[B] [T/R, CS, 3]

Bertini, Ivano, and Claudio Luchinat. "Biodegradation, Enzymes and Mechanisms." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 352-354. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Cat, Bio, CS, 3]

Draths, K. M., and J. W. Frost. "Synthesis Using Plasmid-Based Biocatalysis: Plasmid Assembly and 3-Deoxy-D-arabino-heptulosonate Production." Journal of the American Chemical Society 112 (1990): 1657-1659. [A] [Cat, Opt, Bio, 3]

Frost, John W., and Karen M. Draths. "DHS: A New Intermediate for Oxychemical Synthesis." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 225-226. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [F/R, Cat, Bio, 3]

Glasser, Wolfgang G. "Structural Materials From Naturally Occurring Polymers." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 410. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Bio, CS, 3]

Hudlicky, Tomas. "Biocatalytic Conversion of Halogenated Aromatic Compounds to Carbohydrates and Other Chiral Synthons." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 227. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Cat, Bio, 3]

Marotta, Stephen P., and Richard D. Sheardy. "Mg2+/K+ Induced Self-Assembly of G-Rich DNA Oligomers Into High Molecular Weight Species." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 408-409. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Cat, Bio, 3]

Rotman, David. "The Quest for Reduced Emissions, Greener Processes." Chemical Week 153 (7/14 July 1993): 117-118. [A] [F/R, Bio, CS, 1]

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II.E DEVELOPMENT OF NEW, NON-BIOLOGICAL CATALYSTS

Arzoumanidis, Gregory G., and Nicholas M. Karayannis. "Fine-tuning Polypropylene." Chemtech 23 (July 1993): 43-48.
[A] [Cat, CS, 3]

Bao, Rong, W. Scott Dodson, Thomas C. Bruton, and Yuzhuo Li. "New Applications of Photoinduced Redox Reactions on TiO2 in Organic Synthesis." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 411-415. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Cat, CS, 3]

Bell, A. T., L. E. Manzer, N. Y. Chen, V. W. Weekman, L. L. Hegedus, and C. J. Pereira. "Protecting the Environment Through Catalysis." Chemical Engineering Progress 91 (February 1995): 26-34. [B] Cat, T/R, CS, 2]

Chynoweth, Emma. "Shaping Environmental Solutions With Clay-Based Catalysts." Chemical Week 148 (26 June 1991): 57-58. [B] [Cat, CS, 2]

Clerici, M. G., G. Bellussi, and U. Romano. "Synthesis of Propylene Oxide From Propylene and Hydrogen Peroxide Catalyzed by Titanium Silcalite." Journal of Catalysis 129 (1991): 159-167. [A] [Cat, Opt, CS, 3]

Clerici, Mario G., Patrizia Ingallina, and Luigi Rossi. "Clean Oxidation Technologies: New Prospects in the Epoxidation of Olefins." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 325-327. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Cat, CS, 3]

Dartt, Christopher B., and Mark E. Davis. "Catalysis for Environmentally Benign Processing." Industrial & Engineering Chemistry Research 33, no. 12 (1994): 2887-2899. [A] [Cat, CS, 3]

Dwyer, F.G., P.J. Lewis, and F.H. Schneider. "Efficient, Nonpolluting Ethylbenzene Process." Chemical Engineering 83 (5 January 1976): 90-91. [B] [Cat, CS, 3]

Epling, Gary A., and Qingxi Wang. "Preparative Reactions Using Visible Light: High Yields From Pseudoelectricochemical Transformation." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 65-75. Washington: American Chemical Society, 1994. [A] [F/R, Cat, Econ, 3]

Haggin, Joseph. "Catalysis Critical to Benign Process Design." Chemical & Engineering News 72, no. 16 (18 April 1994): 22-25. [A] [Sol, Cat, CS, 2]

Haggin, Joseph. "Catalysis Gains Widening Role In Environmental Protection." Chemical & Engineering News 72, no. 7 (14 February 1994): 22-30. [A] [Cat, CS, 1]

Haggin, Joseph. "Catalytic Process Cuts Isobutene From C4 Streams." Chemical & Engineering News 71, no. 36 (6 September 1993): 31-32. [A] [Cat, CS, 3]

Haggin, Joseph. "Direct Process Converts Methane to Acetic Acid." Chemical & Engineering News 72, no. 16 (18 April 1994): 5. [A] [Cat, CS, 3]

Jacobson, Andrew, and Gary L. Willingham. "Designing an Environmentally Safe Marine Antifoulant." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, 2]

Johnson, Roy, and Barry Sharpless. "Catalytic Asymmetric Epoxidation of Allylic Alcohols." In Catalytic Asymmetric Syntheses, edited by I. Ojima. New York: VCH Inc., 1993. [A] [Opt, 2]

Jones, Jeffrey P. "Predicting Rates of Cytochrome P450 Mediated Bioactivation, and its Application to the Design of Safe Chemicals." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACSat (202) 872-4564. [B] [T/R, SAR, CS, 3]

Lee, G. J., J. M. Garces, and J. J. Maj. "Applications of Shape Selective 3-DDM Zeolite Catalysts." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 234-235. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Cat, 3]

Manzer, Leo E. "Chemistry and Catalysis: Key to Environmentally Safer Processes." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 144-154. Washington: American Chemical Society, 1994. [A] [Cat, Opt, 2]

Maxwell, I. E., and J. E. Naber. "New and Improved Catalytic Processes for Clean Fuels." Catalysis Letters 12 (1992): 105-116. [A] [F/R, Cat, CS, 3]

Rotman, David. "Successes Emerge in Search for Cleaner Processes." Chemical Week 151 (9 December 1992): 66. [A] [Cat, CS, Econ, 2]

Tundo, Pietro, Carlos Alberto Marques, and Maurizio Selva. "Selective Mono-Methylation of Arylacetonitriles and Methyl Arylacetates by Dimethylcarbonate: A Process Without Production of Waste." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 336-339. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, CS, 3]

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II.F MISCELLANEOUS ALTERNATIVE ROUTES AND ALTERNATIVE CHEMICALS

"Applications of Electrochemical Synthesis of Organics Show Promise." Chemical & Engineering News 63, no. 2 (14 January 1985): 29-31.
[A] [F/R, CS, 2]

Bolzacchini, Ezio, Anna Maria Brambilla, Marco Orlandi, and Bruno Rindone. "The Bis(Salycilideneimino)Ethylenecobalt(II)-Catalyzed Side Chain Oxidation of Lignin Model Compounds With Dioxygen." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 355-358. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [F/R, CS, 3]

Borman, Stu. "Aromatic Amine Route Is Environmentally Safer." Chemical & Engineering News 70, no. 48 (30 November 1992): 26-27. [A] [CS, 3]

Buch, Robert R., and Takashi Kashiwagi. "Silicones and Silicone Additives for Improved Fire Performance." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 277-279. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [EU, CS, 3]

Chapman, Orville L. "The University of California-Los Angeles Styrene Process." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 114-120. Washington: American Chemical Society, 1994. [A] [F/R, CS, *Econ, 3]

Czekaj, C. L., K. A. High, G. H. Laule, and L. L. Phegley. "Waste Minimization and Elimination in Industrial Process Chemistry: The Case of Sulfolane." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 232-233. Presented at the 208th ACS National Meeting, Washington D.C., August 21-25, 1994. [II.F]

DeVito, Stephen C. "Designing Safer Nitriles." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, SAR, 2]

DiCarlo, Frederic J. "Designing Safer Carboxylic Acid." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [EU, 2]

Flam, Faye. "Laser Chemistry: The Light Choice." Science 266 (14 October 1994): 215- 217. [A] [Opt, 3]

Haggin, Joseph. "New Processes Target Methanol Production, Off-gas Cleaning." Chemical & Engineering News 72, no. 13 (March 28, 1994): 29-31. [A] [F/R, CS, 3]

Hall, Nina. "Chemists Clean Up Synthesis With One-Pot Reactions." Science 266 (7 October 1994): 32-34. [A] [Sol, Cat, Opt, Bio, 3]

Harris, N., M. W. Tuck, and Davy McKee. "Butanediol via Maleic Anhydride." Hydrocarbon Processing 69, no. 5 (May 1990): 79-82. [A] [F/R, CS, *Econ, 3]

Hendershot, Dennis C. "Chemistry-The Key to Inherently Safer Manufacturing Processes." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 273-275. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [Sol, Cat, T/R, CS, 3]

Kraus, George A., Masayuki Kirihara, and Yusheng Wu. "A Photochemical Alternative to the Friedel-Crafts Reaction." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 76-83. Washington: American Chemical Society, 1994. [A] [F/R, CS, 3]

Misono, Makoto, and Toshio Okuhara. "Solid Superacid Catalysts." Chemtech 23 (November 1993): 23-29. [A] [Cat, 3]

Nikles, David E., Alan M. Lane, Song Cheng, and Hong Fan. "Pollution Prevention in the Magnetic Tape Industry: Waterborne Coating Formulations for Video Tape Manufacture." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 417-418. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, EU, CS, 3]

Sheldon, Roger A. "Consider the Environmental Quotient." Chemtech 24 (March 1994): 38-46. [C] [CS, *Econ, 3]

Sherrington, David C. "Polymer-Supported Systems: Towards Clean Chemistry?" Chemistry and Industry no. 1 (7 January 1991): 15-19. [A] [Cat, 3]

Sieburth, Scott McN. "Isosteric Replacement of Carbon With Silicon in the Design of Safer Chemicals." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [EU, 3]

Snider, Barry B., and Bridget A. McCarthy. "Mn(III)-Mediated Electrochemical Oxidative Free-Radical Cyclizations." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 84-97. Washington: American Chemical Society, 1994. [A] [F/R, 3]

Stern, Michael K. "Nucleophilic Aromatic Substitution for Hydrogen: New Halide-Free Routes for Production of Aromatic Amines." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 133-143. Washington: American Chemical Society, 1994. [A] [F/R, 3]

Stern, Michael K., and Brian K. Cheng. "Amination of Nitrobenzene via Aromatic Substitution for Hydrogen: Direct Formation of Aromatic Amide Bonds." Journal of Organic Chemistry 58 (1993): 6883-6888. [A] [2]

Stern, Michael K., Brian K. Cheng, Frederick D. Hileman, and James, M. Allman. "A New Route to 4-Aminodiphenylamine via Nucleophilic Aromatic Substitution for Hydrogen: Reaction of Aniline and Azobenzene." Journal of Organic Chemistry 59 (1994): 5627-5632. [A] [F/R, 2]

Stern, Michael K., Fredrick D. Hileman, and James K.Bashkin. "Direct Coupling of Aniline and Nitrobenzene: A New Example of Nucleophilic Aromatic Substitution for Hydrogen." Journal of the American Chemical Society 114 (1992): 9237-9238. [A] [F/R, CS, 3]

Stinson, Stephen. "Cleaner Routes Found to Rubber Antiozonants." Chemical & Engineering News 71, no. 36 (6 September 1993): 30-31. [A] [CS, 3]

Sundaresan, Sankaran, Michael Simpson, and James Wei. "Alkylation of Isobutane With 2-Butene Over Zeolites." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 236-237. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Cat, CS, 3]

Sundell, Mats J., and Jan H. Nasman. "Anchoring Catalytic Functionality on a Polymer." Chemtech 23 (December 1993): 16-23. [A] [F/R, Cat, Opt, 3]

Tanko, James M., and Joseph F. Blackert "Alkylaromatics in Supercritical Carbon Dioxide." Science 263 (January 14, 1994): 203-205. [A] [Sol, 3]

Wilson, Sharon. "Peroxygen Technology in the Chemical Industry." Chemistry and Industry no. 7 (4 April 1994): 255-258. [A] [F/R, *Econ, 2]

Zhang, Zhouyao, Min J. Yang, and Janusz Pawliszyn. "Solid-Phase Microextraction: A Solvent-Free Alternative for Sample Preparation." Analytical Chemistry 66 (1 September 1994): 844A-853A. [A] Sol, 3]

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III. Computer or Mathematical Modeling

Anastas, Paul T., J. Dirk Nies, and Stephen C. DeVito. "Computer-Assisted Alternative Synthetic Design for Pollution Prevention at the U.S. Environmental Protection Agency." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 166-184. Washington: American Chemical Society, 1994.
[C] [Sim, 3]

Anders, M. W. "Structure-Activity Relationships of Haloalkanes." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 377-378. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [T/R, SAR, CS, 3]

Baumel, Irwin P. "Design of Safer Chemicals-An EPA Goal." Drug Metabolism Reviews 15, no. 3 (1984): 415-424. [C] [SAR, 2]

Bodor, Nicholas. "Design of Biologically Safer Chemicals Based on Retrometabolic Concepts." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, SAR, CS, 3]

Bodor, Nicholas. "Soft Drugs: Principles and Methods for the Design of Safe Drugs." Medicinal Research Reviews 4, no. 4 (1984): 449-469. [C] [Opt, SAR, 2]

Casanova, Joseph. "Computer-Based Molecular Modeling in the Curriculum." Journal of Chemical Education 70, no. 11 (November 1993): 904-909. [B] [Sim, 2]

DeVito, Stephen C. "Using Structure-Activity Relationships for the Design of Safer Chemicals." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [SAR, CS, 2]

Hansch, Corwin. "The QSAR Paradigm in the Design of Less Toxic Molecules." Drug Metabolism Reviews 15, no. 7 (1984-85): 1279-1294. [B] [T/R, SAR, 2]

Hendrickson, James B. "The SYNGEN Program for Teaching Alternative Syntheses." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 183-185. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Sim, CS, 2]

Milne, George W. A., and Shaomeng Wang. "Use of Computers in Toxicology." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, SAR, CS, 2]

Rotman, David. "Molecular Modeling Takes on Catalysts." Chemical Week148 (26 June 1991): 52+. [B] [Cat, Sim, 3]

Rotman, David. "Molecular Modeling Takes on Polymers." Chemical Week 147 (17 October 1990): 28, 30. [B] [Sim, 1]

Slone, J. Eric, Paul T. Anastas, Stephen C. DeVito. "Using Computer Assisted Organic Synthesis in the U.S. Environmental Protection Agency's Premanufacture Notification Program: A Case Study in Pollution Prevention." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 221-223. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sim, 3]

Timberlake, Dennis L., and Rakesh Govind. "Expert System for Solvent Substitution." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 215-217. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Sol, EU, CS, 3]

Veith, Gilman D., David De Foe, and Michael Knuth. "Structure-Activity Relationships for Screening Organic Chemicals for Potential Ecotoxicity Effects." Drug Metabolism Reviews 15, no. 7 (1984-85): 1295-1303. [B] [T/R, SAR, 2]

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IV. POLLUTION PREVENTION: RELATED PROGRAMS

Ainsworth, Susan J., and Ann M. Thayer. "Chemical Manufacturers Welcome Challenges of Product Stewardship." Chemical & Engineering News 72 (17 October 1994): 10-31.
[C] [EU, CS, 1]

Amato, Ivan. "The Slow Birth of Green Chemistry." Science 259 (12 March 1993): 1538-1541. [C] [1]

Cavanaugh, Margaret A. "NSF's Environmental Research in the Chemical Sciences: Environmentally Benign Synthesis and Processing Program." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 224. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [1]

Farris, Carol A., Harold E. Podall, and Paul T. Anastas. "Alternative Syntheses and Other Source Reduction Opportunities for Premanufacture Notification Substances at the U.S. Environmental Protection Agency." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 157-165. Washington: American Chemical Society, 1994. [C] [CS, 3]

Flam, Faye. "EPA Campaigns for Safer Chemicals." Science 265 (9 September 1994): 1519. [B] [T/R, EU, 1]

Hancock, Kenneth G., and Margaret A. Cavanaugh. "Environmentally Benign Chemical Synthesis and Processing for the Environment." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 23-30. Washington: American Chemical Society, 1994. [C] [1]

Mitchell, James W. "Alternative Starting Materials for Industrial Processes." Proceedings of the National Academy of Sciences, USA 89 (February 1992): 821-826. [C] [F/R, T/R, 1]

Moss, Ken, and Ray Kent. "Chemical Categories In EPA's New Chemicals Program." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 285-288. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [3]

Thayer, Ann M. "Growing Exchange of Information Spurs Pollution Prevention Efforts." Chemical & Engineering News 71, no. 30 (26 July 1993): 8-25. [C] [CS, 2]

Tobin, Paul S. "Risk Management Through Inherently Safe Chemistry." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 268-270. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

United States Environmental Protection Agency, Office of Research and Development and Office of Pollution Prevention and Toxic Substances; and the National Science Foundation. Proceedings Document: Workshop on Green Syntheses and Processing in Chemical Manufacturing. EPA/600/R-94/125 Washington: EPA, October 1994. (For a free copy, call the NCEPI at 513-891-6561.) [B] [Bio, Sim, CS, 3]

Watts, Daniel J. "Emission Reduction Research Center Pollution Prevention in Batch Chemical Processing Through Selection of Synthesis Condition and Process Design." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 220. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [A] [Sol, Sim, CS, 2]

Williamson, Tracy C., and Paul T. Anastas. "Incorporating Alternative Synthetic Pathway Design Into the Synthetic Chemistry Curriculum: EPA Perspectives." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 177-178. Presented at 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

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V.Overviews or General Discussion

Anastas, Paul T. "Benign by Design Chemistry." In Benign by Design: Alternative Synthetic Design for Pollution Prevention, edited by Paul T. Anastas and Carol A. Farris, 2-22. Washington: American Chemical Society, 1994.
[C] [1]

Anastas, Paul T., and Carol A. Farris, eds. Benign by Design: Alternative Synthetic Design for Pollution Prevention. American Chemical Society Symposium Series, no. 577. Washington: American Chemical Society, 1994. [C] [CS, 2]

Ariens, E. J. Drug Design. New York, Academic Press, 1980. [C] [T/R, EU, 2]

Boethling, Robert S. "Designing Biodegradable Chemicals." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, Bio, EU, CS, 3]

Clarke, Eric A. "Evaluation of the Molecular Design Approach in the Development of New Dyes." Drug Metabolism Reviews 15, nos. 5 & 6 (1984): 997-1009. [B] [SAR, CS, 3]

Dambach, Barry F. "Translating Industrial Ecology Into Design for Environment (DfE)." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 239-242. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [CS, 1]

DeVito, Stephen C. "General Principles for the Design of Safer Chemicals: Toxicological Considerations for Chemists." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, SAR, EU, 2]

Drexler, Eric K. "Molecular Manufacturing: A Sustainable Basis for Global Wealth." Leaders (October/November/December 1993): 98-99. [C] [CS, 1]

Fiksel, Joseph. "Principles of Industrial Ecology and Design for Environment." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 243-246. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Garrett, Roger L. "Designing Safer Chemicals: A New Approach to Pollution Prevention." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [2]

Garrett, Roger L., and Stephen C. DeVito, eds. Designing Safer Chemicals. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, SAR, EU, 2]

Hirschhorn, Joel S. "Enabling Global Implementation of Industrial Pollution Prevention." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 266-267. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Illman, Deborah L. "'Green' Technology Presents Challenge to Chemists." Chemical & Engineering News 71, no. 36 (6 September 1993): 26-30. [C] [Sim, CS, 1]

Illman, Deborah L. "Environmentally Benign Chemistry Aims for Processes That Don't Pollute." Chemical & Engineering News 72, no. 36 (5 September 1994): 22-27. [C] [Bio, 1]

Mittelman, Abe, Daniel Lin, Dorothy Cannon, and C-K Ho. "Inherently Safe Chemistry Guide." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 271-272. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [CS, 3]

Newman, Alan. "Designer Chemistry." Environmental Science & Technology 28, no. 11 (1994): 463A. [C] [T/R, EU, 2]

Newsome, Larry D., Vincent Nabholz, and Ann Kim. "Reducing Aquatic Toxicity Through Safe Chemical Design." In Designing Safer Chemicals, edited by Roger L. Garrett and Stephen C. DeVito. Washington: American Chemical Society, scheduled to be published in fall 1995. For information, call the ACS at (202) 872-4564. [B] [T/R, EU, 3]

Richman, Jack E. "The Rational Design of Active Site Catalysts." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 404-407. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [B] [Cat, CS, 3]

Rotman, David. "Chemists Map Greener Synthesis Pathways." Chemical Week 153 (22 September 1993): 56-57. [C] [CS, 2]

Spitzer, Martin A. "Environmental Accounting." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 247. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [Econ, 2]

Trogler, William C., John D. Simon, and Harry Gray. "Integrating Environmental Chemistry Into Introductory Chemistry for Majors and Nonmajors." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 182. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C] [2]

Trost, Barry M. "The Atom Efficiency-A Search for Synthetic Efficiency." Science 254 (Dec. 6, 1991): 1471-1477. [A] [Opt, 2]

United States Environmental Protection Agency, Office of Research and Development. Guides to Pollution Prevention: Research and Educational Institutions. EPA/625/7-90/010 Washington: EPA, June 1990. (To obtain a free copy, call NCEPI, 513-891-6561.) [C] [1]

Wallace, Michael J. "A Company Program to Introduce Pollution Prevention (P2) Concepts Into Chemical Process Development." American Chemical Society Preprint of Papers, Division of Environmental Chemistry 34, no. 2 (August 1994): 201-202. Presented at the 208th ACS National Meeting, Washington, August 21-25, 1994. [C][CS, 2]

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Periodicals/Publishers

ChemEcology
Chemical Manufacturers Association
2501 M Street NW
Washington, DC 20037
(202) 887-1236

Contains stories about industry pollution prevention initiatives, current issues in the policy arena, science education, new technologies, and recent trends in the environment, health, and safety field. It is published nine times a year, with most of its 75,000 circulation going to educators for use in the classroom. Other subscribers include certain CMA member company employees, government officials, environmental interest groups, and reporters.

Chemosphere
Elsevier Science, Inc.
660 White Plains Road
Terrytown, NY 10591-1513
(914) 524-9200
fax (914) 333-2444

An international, multi-disciplinary journal written to cover issues of environmental protection, health, and safety. Critically reviews new areas of environmental protection. Covers new developments, current research, books, meetings, industrial practices, and government decisions. Articles under the topic "Environmental Chemicals and Analysis" will investigate composition of industrial products, production, and synthesis of chemicals and their properties. Audience includes environmental scientists, chemists, chemical engineers, biologists, toxicologists.

Clean Fuels Report
P.O. Box 649
Niwot, CO 80544
(303) 652-2632

A business and technical journal devoted to clean-burning alternative transportation fuels. Covers worldwide activities concerning compressed natural gas, liquefied natural gas, propane, methane, methanol, ethanol, biofuels, hydrogen, reformulated gasoline, and electric vehicles. Each issue contains an update of government regulations pertaining to alternative transportation fuels at the federal, state, and local levels. The journal is published five times per year at $395.

Environmental Toxicology & Chemistry
Elsevier Science, Inc.
660 White Plains Road
Terrytown, NY 10591-1513
(914) 524-9200
fax (914) 333-2444

The official journal of the Society of Environmental Toxicology and Chemistry. Geared toward professionals in education, industry, and government who are concerned about environmental toxicology and chemistry. Contains integrative articles involving organic, environmental and analytical chemistry; ecology; toxicology; biology; and economics.

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Online Services

CASSI -
Chemical Abstracts Service Source Index
Chemical Abstracts Service
P.O. Box 3012
2540 Olentangy River
Columbus, OH 43210-0012
(800) 753-4227

CCRIS -
Chemical Carcinogenesis Research
Information System
National Library of Medicine
8600 Rockville Pike
Betheseda, MD 20894
(800) 638-8480

ENVIROFATE -
Environmental Fate
Chemical Information Systems, Inc.
810 Glen Eagle Ct., Suite 300
Towson, MD 21286
(410) 321-8440

ISHOW -
Information System for Hazardous Organics in Water
Chemical Information Systems, Inc.
810 Glen Eagle Ct., Suite 300
Towson, MD 21286
(410) 321-8440

TOMES -
Toxicology, Occupational Medicine and Environmental Series Plus System
Micromedex, Inc.
6200 S. Syracuse Way, Suite 300
Englewood, CO 80111-4740
(800) 525-9083

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Faculty Involved in Pollution Prevention and Chemistry

Frank Carey
Dept. of Chemistry and Office of Health & Safety
University of Virginia
Charlottesville, VA 22903
phone: (804) 924-3512
e-mail: fac6q@virginia.edu

Thomas Dunn
Chemistry Department
1539 Chemistry Bldg.
University of Michigan
Ann Arbor, MI 48109-1055
phone: (313) 764-7333
e-mail: tomozdun@umich.edu

Gary Epling
Department of Chemistry
University of Connecticut
U-60
215 Glenbrook Rd.
Storrs, CT 06269-3060
phone:
e-mail:

William H. Glaze
Dept. of Environmental Sciences and Engineering
School of Public Health
University of North Carolina - Chapel Hill
CB#7400, 106 Rosenau Hall
Chapel Hill, NC 27599-7400
phone: (919) 966-1024
fax: (919) 966-2583
e-mail: bill_glaze@unc.edu

Susan Kegley
Department of Chemistry
University of California-Berkeley
Berkeley, CA 94720-3746
phone: (510) 642-3746
e-mail: skegley@garnet.berkeley.edu

Mario Molina
Dept. of Earth, Atmospheric, and Planetary Sciences
Massachusetts Institute of Technology
Building 54-1312
Cambridge, MA 02139
phone: (617) 253-5081
fax: (617) 253-0354
e-mail: mmolina@mit.edu

Steve Pedersen
Department of Chemistry
B84 Hildebrand 1460
University of California-Berkeley
Berkeley, CA 94720-1460
phone: (510) 642-9146
e-mail: pedersen@cchem.berkeley.edu

W. Harmon Ray
Department of Chemical Engineering
University of Wisconsin-Madison
1415 Johnson Dr.
Madison WI 53706
phone: (608) 263-4732
e-mail: ray@engr.wisc.edu

Samuel P. Sawan
Department of Chemistry
University of Massachusetts, Lowell
One University Avenue
Lowell, MA 08154-2881
phone: (508) 934-3680
fax: (508) 943-3028
e-mail: sawans@woods.uml.edu

Alec Scranton
Department of Chemical Engineering
Michigan State University
A202 Engineering Building
East Lansing MI 48824-1226
phone: (517) 353-3516
fax: (517) 336-1105
e-mail: scranton@egr.msu.edu

Leverett Smith
Department of Chemistry
Contra-Costa College
2600 Mission Bell Drive
San Pablo, CA 94806
phone: (510) 235-7800, ext. 389
e-mail:

Thomas Spiro
Chemistry Department
Princeton University
Princeton, NJ 08540
phone: (609) 258-3907
fax: (609) 258-6746
e-mail: spiro@chemvax.princeton.edu

James Tanko
Department of Chemistry
Virginia Polytechnic Institute and State University
107 Davidson Hall
Blacksburg, VA 24061-0212
phone: (703) 231-6687
e-mail: jtanko@chemserver.chem.vt.edu

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Organizations

American Chemical Society
1155 16th Street NW
Washington, DC 20036
phone: (202) 872-4600

The Division of Environmental Chemistry in the American Chemical Society (ACS) seeks to promote research, disseminate information and improve education and public awareness regarding chemistry of the environment. Symposium topics have included benign synthesis, design for the environment, and design of safer chemicals.

American Institute of Chemists Alexandria, VA 22314-1917
phone: (703) 836-2090
fax: (703) 836-2091
e-mail: 76744.2677@compuserve.com

The American Institute of Chemists (AIC) is a nonprofit association that represents more than 5,000 chemists, chemical engineers and biochemists. Members keeps informed of developments in the chemical field through the AIC publication The Chemist. Although not directly involved with pollution prevention, AIC will refer inquiries regarding pollution prevention in the chemistry field to an appropriate member.

Chemical Manufacturers Association
2501 M Street NW
Washington, DC 20037
phone: (202) 887-1100

The Chemical Manufacturers Association (CMA) requires all member companies to join the CMA- sponsored Responsible Care Program, which includes the pollution prevention code of management. CMA's mutual assistance program gives new members the opportunity to link up with members who have been successful in achieving their pollution prevention goals.

National Microscale Chemistry Center
Merrimack College
N. Andover, MA 01845
phone: (508) 837-5137
fax: (508) 837-5017
e-mail: msingh@merrimack.edu

The mission of the National Microscale Chemistry Center (NMC2) is to "implement the ideas of chemical-use reduction, air-quality improvement, exposure limitation, recycling, and waste reduction into every chemical worker's and every student's thinking." NMC2 has published numerous laboratory textbooks and manuals for microscale organic and inorganic chemistry. Contact NMC2 for a list of publications.

Synthetic Organic Chemical Manufacturers Association
1330 Connecticut Avenue NW, Suite 300
Washington, DC 20036
phone: (202) 659-0060

The Synthetic Organic Chemical Manufacturers Association (SOCMA) is currently developing a program modeled after CMA's Responsible Care Program. SOCMA's version of Responsible Care will be designed to confront the issues specific to SOCMA's members.

Economics, Exposure, and Technology Division
U.S. Environmental Protection Agency
Office of Pollution Prevention and Toxics(OPPT)
401 M Street SW (MC 7406)
Washington, D.C. 20460
phone: (202) 260-3960
fax: (202) 260-0981

The Economics, Exposure, and Technology Division (EETD) performs all technical analyses in the areas of economics, industrial chemistry, engineering, and exposure assessment in support of all OPPT regulatory and non-regulatory programs. In addition, EETD manages the Toxic Substance Control Act inventory and the Design for the Environment Program.


*Keoleian and Menerey. Life Cycle Design Framework and Demonstration Projects: Profiles of AT&T and AlliedSignal. Cincinnati: Risk Reduction Engineering Laboratory, U.S. Environmental Protection Agency; May 1995.

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Matrix

Themes:

I. Incorporating P2 into curricula
II. Less-toxic alternatives in synthesis
II.A. Alternatives to phosgene
II.B. Supercritical CO2
II.C. D-Glucose
II.D. Biocatalysis/biological reagents
II.E. Non-biological catalysts
II.F. Miscellaneous routes/chemicals
III. Computer/mathematical modeling
IV. P2-related programs
V. Overviews/general discussion

Subject Classifications:

A = Alternative synthesis
B = Alternative chemical
C = Background info/gen. discussion

Audience Codes:

1 = Some elementary science
2 = Undergraduate knowledge of science
3 = Advanced knowledge (faculty, etc.)

Content Classifications:

F/R = Feedstock/Reactant
Sol = Solvent
Cat = Catalyst
Opt = Optimization
T/R = Toxicity/Risk Assessment
SAR = Structure-Activity Relationships
Bio = Biological
Sim = Computer Simulation
EU = End-Use
* = Economic
CS = Case Study

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-
Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Ainsworth & ThayerlV--1--------11
AmatolV--1----------
AnastasV--1----------
Anastas & FarrisV--2---------2
Anastas, Niles, & DeVitolll--3--------3-
Anders (1994; "Designing...")ll.D-3-----3----3
Anders (1994; "SARs...")lll--3----33---3
"Applications of Electro. ..."ll.F2--2--------2
Arestall.B3--3-3-------
AriensV--2----2---2-
Arzoumanidis & Karayannisll.E3----3------3
Bao et al.ll.E3----3------3
Baumellll--2-----2----
Bell et al.ll.E-2---2-2----2
Bertini & Luchinatll.D3----3---3--3

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Bodor (1995)lll-3-----33--33
Bodor (1984)lll--2---2-2--2-
BoethlingV-3-----3-3-33
Bolzacchini et al.ll.F3--3--------3
Bormanll.F3-----------3
Bradleyll.B--2-22-------
Buch & Kashiwagill.F3----------33
Carey & Carey*l--2----------
Casanovalll-2--------2--
CavanaughlV--1----------
Chapman*ll.F3--3-------3-
Chynowethll.E-2---2------2
ClarkeV-3------3---3
Clerici, Bellussi, & Romanoll.E3----33-----3
Clerici, Ingallina, & Rossill.E3----3------3

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Combees, Guan, DeSimonell.B2---2-------2
Czekaj et al.ll.F2---22------2
DambachV--1---------1
Dartt & Davisll.E3----3------3
Dell & Frostll.C3----33------
DePompeill.A-3---------33
DeSimone et al.ll.B3---3-------3
DeSimone, Guan, & Eisberndll.B2---2-------2
DeVito (1995; "Designing...")ll.F-2-----22--22
DeVito (1994; "General...")V-2-----22--2-
DeVito (1994; "Using SAR's...")lll-2------2---2
DiCarloll.F-2---------2-
Donohue & Geigerll.B3---3-------3
Draths & Frost (1991)ll.C3----3---3---
Draths & Frost (1990)ll.D3----33--3---

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Draths & Frost (1994; "Environ...")ll.C3--3-3---3---
Draths & Frost (1994;"Microb...")*ll.C3--3-3---3---
Draths et al.ll.C3-----3--3---
Draths, Ward, & Frostll.C2--2-----2---
DrexlerV--1---------1
Dwyer, Lewis, & Schneiderll.E-3---3------3
Emsleyll.C3--3-----3--3
Epling & Wang*ll.E3--3-3-------
Farris, Podall, & AnastaslV--3---------3
FikselV--2----------
Flam (1994; "EPA Campaigns...")lV-1-----1---1-
Flam (1994; "Laser Chemistry...")ll.F3-----3------
Frost & Lievense*ll.C2--2-2---2--2
Frost & Drathsll.D3--3-3---3---
Frostll.C1--1-1---1---

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Gargulak & Gladfelterll.A3----33------
GarrettV-2-----------
Garrett & DeVitoV-2-----22--2-
"Gassy Plastics."ll.B1---1-------1
Glasserll.D-3-------3--3
Guan & DeSimonell.B3---3--------
Haggin (1994: "Cat. Critical...")ll.E2---22------2
Haggin (1994; "Cat. Gains...")ll.E1----1------1
Haggin (1993; "Cat. Process...") ll.E3----3------3
Haggin (1994; "Direct...")ll.E3----3------3
Haggin (1994; "New...")ll.F3--3--------3
Hallll.F3---333--3---
Hancock & CavanaughlV--1----------
Hanschlll-2-----22----
Harris, Tuck, & McKee*ll.F3--3--------3

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Hendershotll.F--3-33-3----3
Hendricksonlll-2--------2-2
HirschhornV--2----------
Hudlickyll.D3----3---3---
Huheeyl--2----------
Illman (1993)V--1-------1-1
IllmanV--1------1---
Jacobson & Willinghamll.E-2------2--2-
Johnson & Sharplessll.E2------2-----
Johnstonll.B2---2--------
Jonesll.E-3-----33---3
Keoleian & Bulkleyl--1----------
Komiya et al.ll.A3--3--------3
Kraus, Kirihara, & Wull.F3--3--------3
Lee, Garces, & Majll.E-3---3-------

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Limll.B3---33------3
Manzerll.E2----22------
Marotta & Sheardyll.D-3---3---3---
Maxwell & Naberll.E3--3-3------3
McGhee, Yi, & Rileyll.A3--3---------
McGhee et al.ll.A3--3---------
Milne & Wanglll-2-----22-2--
Misono & Okuharall.F3----3-------
MitchelllV--11---1-----
Mittelman et al.V--3---------3
Moss & KentlV--3----------
NewmanV--2----2---2-
Newsome, Nabholz, & KimV-3-----3---3-
Nikles et al.ll.F3---3------33
RichmanV-3---3------3

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Riley, McGhee, & Waldmanll.A3--3--------3
Rotman (1993;"Chemists...")V--2---------2
Rotman (1991)lll-3---3----3--
Rotman (1990)lll-1--------1--
Rotman (1992) *ll.E2----2------2
Rotman (1993;"The Quest...")ll.D1--1-----1--1
Sawan, Shieh, & Sull.B--3-3-------3
Sheldon *ll.F--3---------3
Sherringtonll.F3----3-------
Sieburthll.F-3---------3-
Singh, Pike, & Szafranl2------------
Slone, Anastas, & DeVitolll3---------3--
Smithl--2----------
Snider & McCarthyll.F3--3---------
Spitzer *V--2----------

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Steinfeld & Beml--2----------
Sternll.F3--3---------
Stern & Chengll.F2------------
Stern et al.ll.F2--2---------
Stern, Hileman, & Bashkinll.F3--3--------3
Stinsonll.F3-----------3
Sundaresan, Simpson, & Weill.F3----3------3
Sundell & Nasmanll.F3--3-33-----3
Szafran, Singh, & Pikel--1----------
Tanko & Blackertll.F3---3--------
Tanko, Blackert, & Sadeghipourll.B2---2--------
Tanko et al.ll.B3----33------
ThayerlV--2---------2
Timberlake & Govindlll-3--3-----333
Tobinlv--2----------

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to the Matrix Codes

Author(s) Theme A B C F/R Sol Cat Opt T/R SAR Bio Sim EU CS
Trogler, Simon, & GrayV--2----------
TrostV2-----2------
Tullyl--3---------3
Tumas et al.ll.B3---33-------
Tundro, Marques, & Selvall.E3---3-------3
U.S. EPA and NSFlV-3-------33-3
U.S. EPAV--1----------
Veith, De Foe, & Knuthlll-2-----22----
Vellacciol--2----------
Waldman & McGheell.A3--3--------3
WallaceV--2---------2
WattslV2---2-----2-2
Williamson & AnastaslV--2----------
Wilson*ll.F2--2---------
Zhang, Yang, & Pawliszynll.F3---3--------
Zwaard, Vermeeren, and de Gelderll.F--11-1-1-----
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to the Matrix Codes



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last revised: September 5,1997.