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Current Research Projects

Flavin Research.     Mechanism of an electron/proton transfer protein.

                                Single Molecule Studies of p-hydroxybenzoate hydroxylase (PHBH)
                               
                                Single Molecule Studies of DHOD (Dihydroorotate Dehydrogenase)

                                Monte Carlo Simulation of Single Molecule Kinetics

Heat Shock Factor 1 (HSF1).  Biophysical study of the mechanism for the activation of a transcription factor

                                       Background

                                Characterization of recombinate HSF1

Plasminogen Activator Inhibitor (PAI-1)  Study of the Mechanism of a Serine Protease Inhibitor.

                                        Picosecond time-resolved studies of tryptophan fluorescence.

                                Single Molecule Studies of Plasminogen Activator Inhibitor (PAI-1)


Some Former Research Projects 

Amylin Research 

Alkaline Phosphatase Research 

Near Field Spectroscopy Project

This work has been supported by;
National Institutes of Aging
Office of Naval Research
Michigan Life Sciences Corridor
Nathan Shock Center (NIA)
Ellison Foundation
Michigan Alzheizer's Disease and Research Center
Michigan Diabetes Research and Training Center.