Al-Hashimi Movie S1  -- This animation shows in three dimensions how the two helical portions of an RNA molecule bend and twist in a highly concerted manner. The specific RNA molecule shown here, known as TAR, is critical for replication of HIV, making it a key target for anti-HIV drugs.

 

 

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Al-Hashimi Movie S2 – This animation of the RNA molecule known as TAR shows (in gray) the various conformations the molecule takes when bound to different molecules, including drugs designed to combat HIV. The moving green image shows how the RNA molecule bends and twists. Together, the images illustrate how the molecule passes through various critical conformations in the process of bending and twisting.