The ability of molecules to crystallize in more than one arrangement in the solid state has profound implications for a variety of phenomena including pigment properties, solid state reactivity, and pharmaceutical performance. We are developing techniques to control the process of crystallization in a general fashion with the goal of making materials with improved functionality. Our approach exploits polymers as phase directors. Combinatorial materials chemistry plays a vital role in these efforts as do advanced analytical techniques including X-ray microdiffraction, thermal analysis, and Raman spectroscopy. Design of new polymeric systems for controlling pharmaceutical crystallization and elucidating mechanisms of form selection are topics of current interest.
López-Mejías, V.; Kampf, J. W.; Matzger, A. J. "Nonamorphism in Flufenamic Acid and a New Record for a Polymorphic Compound with Solved Structures" J. Am. Chem. Soc., 2012, 134, 9872-9875 (online)
López-Mejías, V.; Knight, J. L.; Brooks, C. L., III; Matzger, A. J., "On the Mechanism of Crystalline Polymorph Selection by Polymer Heteronuclei" Langmuir, 2011, 27, 7575-7579 (online)
Lutker, K. M.; Quiñones, R.; Xu, J.; Ramamoorthy, A.; Matzger, A. J., "Polymorphs and hydrates of acyclovir" J. Pharm. Sci., 2011, 100, 949-963 (online)
McClelland, A. A.; López-Mejías, V.; Matzger, A. J.; Chen, Z., "Peering at a Buried Polymer-Crystal Interface: Probing Heterogeneous Nucleation by Sum Frequency Generation Vibrational Spectroscopy" Langmuir, 2011,27, 2162-2165 (online)