The ability of molecules to crystallize in more than one arrangement in the solid state has profound implications for a variety of phenomena including pigment properties, solid state reactivity, and pharmaceutical performance. We are developing techniques to control the process of crystallization in a general fashion with the goal of making materials, such as pharmaceuticals, with improved functionality. Our approach exploits polymers as phase directors. Combinatorial materials chemistry plays a vital role in these efforts, as do advanced analytical techniques including X-ray microdiffraction, thermal analysis, and Raman spectroscopy. Design of new polymeric systems for controlling pharmaceutical crystallization and elucidating mechanisms of form selection are topics of current interest, as well as developing novel pharmaceutical cocrystal materials.
Kersten, K. M., & Matzger, A. J. "Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate." Chem. Commun, 2016 (online)
Li, Z.; Matzger, A. J. "Influence of Coformer Stoichiometric Ratio on Pharmaceutical Cocrystal Dissolution: Three Cocrystals of Carbamazepine/4-Aminobenzoic Acid" Mol. Pharmaceutics, 2016 (online)
Pfund, L. Y.; Price, C. P.; Frick, J. J.; Matzger, A. J. "Controlling Pharmaceutical Crystallization with Designed Polymeric Heteronuclei" J. Am. Chem. Soc., 2015, 137, 871-875 (online)
Pfund, L. P.; Chamberlin, B. L.; Matzger, A. J. "The Bioenhancer Piperine is at Least Trimorphic" Cryst. Growth Des., 2015, 15, 2047-2051 (online)