Matzger Research Group
Porous Materials
Crystal Polymorphism
Physisorbed Monolayers
Energetic Materials
Crystal Polymorphism

The ability of molecules to crystallize in more than one arrangement in the solid state has profound implications for a variety of phenomena including pigment properties, solid state reactivity, and pharmaceutical performance. We are developing techniques to control the process of crystallization in a general fashion with the goal of making materials with improved functionality.  Our approach exploits polymers as phase directors. Combinatorial materials chemistry plays a vital role in these efforts as do advanced analytical techniques including X-ray microdiffraction, thermal analysis, and Raman spectroscopy.  Design of new polymeric systems for controlling pharmaceutical crystallization and elucidating mechanisms of form selection are topics of current interest.

Recent Publications

López-Mejías, V.; Kampf, J. W.; Matzger, A. J. "Nonamorphism in Flufenamic Acid and a New Record for a Polymorphic Compound with Solved Structures" J. Am. Chem. Soc., 2012, 134, 9872-9875 (online)

López-Mejías, V.; Knight, J. L.; Brooks, C. L., III; Matzger, A. J., "On the Mechanism of Crystalline Polymorph Selection by Polymer Heteronuclei" Langmuir, 2011, 27, 7575-7579 (online)

Lutker, K. M.; Quiñones, R.; Xu, J.; Ramamoorthy, A.; Matzger, A. J., "Polymorphs and hydrates of acyclovir" J. Pharm. Sci., 2011, 100, 949-963 (online)

McClelland, A. A.; López-Mejías, V.; Matzger, A. J.; Chen, Z., "Peering at a Buried Polymer-Crystal Interface: Probing Heterogeneous Nucleation by Sum Frequency Generation Vibrational Spectroscopy" Langmuir, 2011,27, 2162-2165 (online)

Updated 9/23/2012