| "Role
of acute physical activity and diet on lipid metabolism" |
| |
Major Goals:
Evaluate the effect of a single day of physical inactivity on
the clearance of triglycerides from the circulation and determine
their metabolic fate (e.g.; incorporation into lipoproteins,
oxidation, storage). |
| "Effect
of fatty acid availability of muscle metabolism and insulin
sensitivity" |
| |
Major Goals: Determine the impact of increasing fatty acid availability
in the hours after exercise (via lipid-heparin infusion) on
intramuscular triglyceride resynthesis and on the exercise-induced
increase in insulin sensitivity. |
| "Effect
of exercise training and weight loss on muscle fatty acid metabolism
and insulin sensitivity in obese adults" |
| |
Major Goals:
Examine the abnormalities in lipid metabolism (whole-body and
cellular) that may lead to insulin resistance and put people
at risk for diabetes and other obesity-related diseases, and
determine how weight-loss and exercise training may impact these
responses. Identifying relationships between gene expression,
whole-body fatty acid metabolism and clinical outcome measurements
such as insulin sensitivity and serum lipid profiles, may lead
to improvements in the therapeutic and/or preventative approach
to obesity and its co-morbidities. |
| "Improving
muscle power and mobility of elderly men and women" |
|
Major Goals:
This multi-disciplinary study, funded by the Michigan
Life Sciences Corridor, focuses on how and why exercise
improves the strength and mobility of elderly people.
|
| “Metabolic adaptations to a short-term low-carbohydrate diet” |
| |
Major goal(s): Determine the effect of 1 week carbohydrate restriction (without caloric deficit or weight-loss) on lipid, glucose, and protein metabolism and factors that regulate these processes. |
| “Fatty acid metabolism and insulin sensitivity after exercise in obesity” |
| |
Major goal(s) : Determine the impact of a single session of exercise and the content of meals after exercise on insulin sensitivity and the regulation of lipid and glucose metabolism the next day. |
| “Determining the metabolic fate of ingested lipids: role of added carbohydrates” |
| |
Major goal(s): Examine how eating carbohydrate and the resultant insulin response alters the metabolic fate of ingested fat (e.g.; oxidized, incorporated into other lipids or lipoproteins, remain in circulation). |
| “Physiological importance of growth hormone pulsatility” |
| |
Major goal(s): Determine the effect of different methods of growth hormone administration (constant dose vs. pulsatile dose) on lipid and protein metabolism in persons with growth hormone hormone deficiency. |
| “Metabolic adaptations of obesity with growth hormone administration” |
| |
Major goal(s): Evaluate the effect of growth hormone administration on lipolysis, glucose uptake, and protein synthesis in persons with abdominal obesity. |
“Effect of the blockage of growth hormone with growth hormone releasing hormone antagonist on protein, lipid and glucose metabolism” |
| |
Major goal(s): Determine the influence of growth hormone on fat, carbohydrate, and protein metabolism by inhibiting the secretion of growth hormone in healthy young adults. |
| Faculty: |
Dr. Horowitz (standing) and Ph.D. student Nick
Knuth |
|
Jeffrey
Horowitz, Ph.D. (jeffhoro@umich.edu),
Director |
| Postdoctoral scholar |
| |
Matthew Harber, Ph.D. (mharber@umich.edu) |
| Study Coordinator/Dietician |
| |
Cara Malear, R.D. (cmalear@umich.edu) |
| Doctoral
Student(s): |
|
Nicholas
Knuth (nknuth@umich.edu) |
|
Simon
Schenk (sschenk@umich.edu) |
| Undergraduate
Students |
| |
Michele Emory (emorym@umich.edu) |
| |
Dan Faden (dfaden@umich.edu) |
| |
Kevin Jamil (kgjamil@umich.edu) |
| |
Andrew Lockton (alockton@umich.edu) |
|
David Remias (dremias@umich.edu) |
| Collaborators |
|
Ariel
Barkan, M.D. (abarkan@umich.edu),
UM Internal Medicine [Endocrinology & Metabolism] |
|
Charles
Burant, M.D., Ph.D. (burantc@umich.edu),
UM Internal Medicine [Endocrinology & Metabolism] |
|
Bruce
Carlson, M.D., Ph.D. (brcarl@umich.edu),
UM Institute of Gerontology |
| |
John
Faulkner, Ph.D. (jafaulk@umich.edu),
UM Institute of Gerontology |
