UM Biophysics Faculty | Mark M Banaszak Holl

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Mark M Banaszak Holl

Surface Science of Biological Systems - Cells and Bilayers

Mark Banaszak Holl

Nano-designed Drug Delivery Agents

Nanoparticle Toxicity

Ph.D., Cornell University

Dept: Professor - Chemistry

Office Address: 2813 Chemistry

Phone: 763-2283

Email: mbanasza@umich.edu

Lab homepage

The research program focusses on targeted drug delivery of chemotherapeutic agents and the resulting cell apoptosis (programmed cell death). We are particularly interested in polymer/cell interactions and how best to design nanoscale delivery systems so that they are not intrinsically toxic. We employ model systems ranging from supported lipid bilayers to cancer cells grown in vitro. Extensive use of Atomic Force Microscopy (AFM) is typically employed in addition to other techniques such as confocal microscopy and cell flow cytometry.

We are studying the effects of nanoparticles on cell membranes and the relationship of these interactions to nanoparticle toxicity. We have discovered that nanoparticles can induce the formation of nanoscale holes into cell membranes. We are continuing to explore the variety of ways that nanoparticles can enter cells and the types of interactions that occurs with cell machinery.

Another major research thrust involves the study of poly(amidoamine)(PAMAM) dendrimers as drug transport agents. This work is done in collaboration with the other scientists at the Michigan Nanotechnology Institute for Medical and Biological Sciences at the University of Michigan. The polymeric particle used as the platform for drug transport is the PAMAM dendrimer.

Representative Publications

Membrane thinning due to antimicrobial peptide binding – An AFM study of MSI-78 in DMPC bilayers. A. Mecke, D.-K. Kee, A. Ramamoorthy, B. G. Orr, and M. M. Banaszak Holl. Biophysical Journal 2005, 89, 4043-4045.

Lipid Bilayer Disruption by Polyamidoamine Dendrimers: The Role of Generation and Capping Group. A. Mecke, B. G. Orr, M. M. Banaszak Holl, J. R. Baker. Langmuir 2005, 21, 10348-10354.

An Atomic Force Microscopy Study of Early Morphological Changes During Apoptosis. J. Hessler, A. Budor, K. Putchakayala, A. Mecke, D. Rieger, M. M. Banaszak Holl, B. G. Orr, A. Bielinska, J. Beals, and J. R Baker Jr. Langmuir 2005, 21, 9280-9286.

The Interaction of Polyamidoamine (PAMAM) Dendrimers with Supported Lipid Bilayers and Cells: Hole Formation and the Relation to Transport. S. Hong, A. U. Bielinska, A. Mecke, B. Keszler, J. L. Beals, X. Shi, L. Balogh, B. G. Orr, J. R. Baker Jr., and M. M. Banaszak Holl. Bioconjugate Chemistry 2004, 15, 774-782.

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Biophysics Research Division University of Michigan 4028 Chemistry Building 930 North University Avenue Ann Arbor, MI 48109-1055 UMsitemaker	Phone: (734) 763-6722 Fax: (734) 764-3323 E-mail: biophysics@umich.edu Last Updated: 5/15/2006 © Copyright 2006 University of Michigan