UM Biophysics Faculty | Joel Swanson

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Joel Swanson

Endocytosis and Signal Transduction in Macrophages

Professor, Department of Microbiology and Immunology

Associate Research Scientist, Biophysics Research Division

Ph.D., Princeton University

Dept: Microbiology and Immunology

Office Address: 5608 Med Sci II

Phone: (734) 647-6339

Email: jswan@umich.edu

Research Group

Endocytosis and Signal Transduction in Macrophages and the Physiology
of Activated Macrophages. Central to defense against pathogenic microorganisms
is the macrophage's ability to internalize fluids and particles by endocytosis,
which includes the processes of phagocytosis, receptor-mediated endocytosis,
and pinocytosis. This lab uses quantitative fluorometric and microscopic
methods to quantify signal transduction inside living macrophages.
Quantitative methods are being developed for measuring localized protein-protein
interactions by fluorescence resonance energy transfer (FRET) microscopy.
Our goals are to delineate the mechanisms and regulation of phagocytosis,
and to characterize the intravacuolar environment in the presence and absence
of pathogenic bacteria

Joel Swanson Lab Page

Representative Publications

Hoppe, A. D., K. A. Christensen and J. A. Swanson. 2002. Fluorescence resonance energy transfer-based stoichiometry in living cells. Biophys. J. 83: 3652-3664.

Hoppe, A. D. and J. A Swanson. 2004. Cdc42, Rac1 and Rac2 display distinct patterns of activation during phagocytosis. Mol. Biol. Cell 15: 3509-3519.

Swanson, J. A. and A. D. Hoppe. 2004. The coordination of signaling during Fc receptor-mediated phagocytosis. J. Leukoc. Biol. 76: 1093-1103.

Shaughnessy, L., A. D. Hoppe, K. A. Christensen and J. A. Swanson. 2006. Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuoles. Cell. Microbiol. 8: 781-792.

Beemiller, P., A. D. Hoppe and J. A. Swanson. 2006. A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fc-gamma receptor-mediated phagocytosis. PLoS Biology 6(4) 1-13.

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