Leading Question:

Discuss two alternatives for HOBt that can be used in glycosylation reactions and discuss the advantages/ disadvantages of each reagent.

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Alternative Compound

Advantages

Disadvantages

Second Reagent
1-Hydroxy-7-azabenzotriazole
  • Work similar to HOBt
  • Reacts quickly
  • Commercially available

 

  • More expensive than HOBt

One Reagent
N-Hydroxysuccinimide
  • Works similar to HOBt
  • Strong acid
  • Would protonate the –OH quickly
  • Comercially Available
  • More expensive then HOBt