Introduction

A year ago, Grand Master Koreeda, who is a frontrunner of discovering unknown mysteries of chemistry in the land of Azeroth, has been attacked by the mages. Those villain who had unreasonable hatred toward Grand Master Koreeda's progress were soon captured, but the Grand Master has fallen into coma. Without him, it would be impossible to continue his ultimate project on the transformation of α-diazo-β-ketonitrile to norcaradiene. According to the ancient article we found (assumed to be written by ancient chemist named Reisman), the prepared norcaradiene is used in the significant step to synthesize (+)-salvileucalin B, which can be used in a various therapeutic applications.

 

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However, from the tragic day, many of his followers fell into despair.

 

Recently, Master Gildenberg, one of Grand Master Koreeda's best apprentices, found a journal in dust. It turned out to be the Grand Master's records of his experiment on the transformation. From the journal, they figured out that the Intramolecular cyclopropanation is triggered by the metal ligand named Cu(hfacac)2, forcing the electrophilic N2 to act as a leaving group.

 

As if light shines after a long night with nightmares, everybody is now on their feet to finish the project, with one hope to recover Grand Master Koreeda and another for their own.

Citation

The following is the ancient article discovered by the Grand Master and Master Gildenberg long times ago.

 

Reisman, S. E.; Levin, S.; Nani, R. R. J. Am. Chem. Soc. 2011, 133, 774-776.

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hope this is cool enough for you, melissa!