\

To our visitors from outside the Chemistry 215H course:


The documents linked below were solely generated by a class-wide collaboration between the second-term first year students in the honors section of Chemistry 215/216 during the Winter 2016 Term. The assignments that resulted in these pages were designed in collaboration with the three junior/senior undergraduate leaders who are pictured below. You can find out more details about how these pages are created, and the Structured Study Group program in general, by referencing other parts of the Chemistry 215H/216H web site.

Tutorials

[ GIF Animations | Excel | HTML | Mouse-over 1 | Mouse-overs 2 | SciFinder ]


Wednesdays 5:00-7:00pm

Peng, F.; Danishefsky, S. J. J. Am. Chem. Soc. 2012, 134, 18860-18867.

Batzelladines are a novel class of polyguanidine alkaloids that exhibit anti-HIV properties - Batzelladines A and B inhibit binding of the HIV envelope protein gp-120 to the human CD4 receptor which subsequently prevents infection of the host cell by the HIV. Because of their unique structure and potential as therapeutics for HIV, these researchers were encouraged to develop a method for the synthesis of batzelladines. In this paper, Cohen et al describe the first enantioselective total synthesis of a batzelladine alkaloid using a novel Biginelli condensation of a guanidine aldehyde and an acetoacetic ester to generate a key intermediate.

danny

 




"As the presidential candidates Bernie Sanders, Hillary Clinton, Donald Trump, Marco Rubio, and Ben Carson make their push towards the highest office in the United States, they will engage in fundraising efforts, publicity tours, and polite political discourse - maybe not so much. Join the students of SSG 1 as they too push towards the completion of Chem 215H and the end of their semester by exploring the chemistry of Batzelladine D."


Wednesdays 7:00-9:00pm

Arnold, M. A.; Day, K. A.; Durón, S. G.; Gin, D. Y. J. Am. Chem. Soc. 2006, 128, 13255-13260.

Batzelladines are a class of natural alkaloid compounds that have been the focus of recent synthetic efforts because of their recently discovered anti-HIV activity. This paper describes the total syntheses of (+)-batzelladine A and (-)-batzelladine D using a [4+2] annulation of vinyl carbodiimides and N-alkyl imines.

 






"Join our young elemental benders as they seek to master the elements in their quest to become the one and only Orgotar: The Last Chairbender. "


Thursdays 7:00-9:00pm

Evans, P. A.; Qin, J.; Robinson, J. E.; Bazin, B. Angew, Chem., Int. Ed. 2007, 46, 7417-7419.

Batzelladines are important class of natural alkaloids with important biological activity such as HIV inhibition. However, selective synthesis of the desired enantiomer of target molecules, such as the batzelladines, are an important problem in synthetic chemistry. Evans, et al. propose a stereoselective synthesis of (-)-Batzelladine D.

 







"The rise of dating apps offers unprecedented changes in how we connect romantically with others. If you dream of finding the right molecule, if you dream of connecting with the natural alkaloid (-)-Batzelladine D, join SSG 3 on Chemistry.com, where we offer a plethora of dating apps and websites to satisfy all your molecular pursuits! "


 

Website by Eric Chen. Style copyright © 2016 The Regents of the University of Michigan.