Contact Information
Lab Room 2250
Chemistry Dept.
930 N. University
Ann Arbor 48109




Scholar                     Pubmed

58. W Zhou, K Håkansson, Electron Capture Dissociation of Divalent Metal-adducted Sulfated N-Glycans Released from Bovine Thyroid Stimulating Hormone. J. Am. Soc. Mass Spectrom. 2013, vol 24, 11, 1798-1806 [pdf].
57. JR Kornacki, JT Adamson, K Håkansson, Electron Detachment Dissociation of Underivatized Chloride-Adducted Oligosaccharides. J. Am. Soc. Mass Spectrom. 2012, vol 23, 11, 2031-2042 [pdf].
56. KE Hersberger,K Håkansson.Characterization of O-Sulfopeptides by Negative Ion Mode Tandem Mass Spectrometry: Superior Performance of Negative Ion Electron Capture Dissociation. Anal. Chem. 2012, vol. 84, 15, 6370-6377 [pdf].
55. HT Song, K Håkansson, Electron Detachment Dissociation and Negative on Infrared Multiphoton Dissociation of Electrosprayed Intact Proteins. Anal. Chem. 2012, vol. 84, 2, 871-876  [pdf].
54. W Zhou, K Håkansson. Electron Detachment Dissociation of Fluorescently Labeled Sialylated Oligosaccharides. Electrophoresis 2011, in press. [pdf].
53. HJ Yoo, N Wang, S Zhuang, H Song, K Håkansson. Negative Ion Electron Capture Dissociation: Radical-Driven Fragmentation of Charge-Increased Gaseous Peptide Anions. J. Am. Chem. Soc.2011, in press, DOI: 10.1021/ja207736y [pdf].
52. W Zhou, K Håkansson. Structural Determination of Carbohydrates by Fourier Transform Tandem Mass Spectrometry. Curr. Proteomics. 2011, in press.
51. CM Rath, B Janto, J Earl, A Ahmed, FZ Hu, L Hiller, M Dahlgren, R Kreft, F Yu, JJ Wolff, HK Kweon, MA Christiansen, K Håkansson, R Williams, G Ehrlich, DH SHerman. Meta-omic Characterization of the Marine Invertebrate Microbial Consortium that Produces the Chemotherapeutic Natural product ET-743. ACS Chem. Biol. 2011, in press, DOI: 10.1021/cb200244t [pdf].
50. A Kalli, G Grigorean, K Håkansson. Electron Induced Dissociation of Singly Deprotonated Peptides. J. Am. Soc. Mass Spectrom. 2011, in press, DOI: 10.1007/s13361-011-0233-6 [pdf].
49. Y Ding, CM Rath, KL Bolduc, K Håkansson, DH Sherman. Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond Forming NRPS Module. J. Am. Chem. Soc. 2011133, 14492-14495 [pdf].
48. SA Bonnett, CM Rath, R Shareef, JR Joels, J Chemler, K Håkansson, K Reynolds, DH Sherman. Acyl-CoA Subunit Selectivity in the Terminal Pikromycin Polyketide Synthase Module: Steady-State Kinetics and Active-Site Occupancy Analysis by FTICR-MS. Chem. Biol. 201118, 1075-1081 [pdf].
47. HC Liu, K Håkansson. Electron Capture Dissociation of Divalent Metal-Adducted Sulfated Oligosaccharides. Int. J. Mass Spectrom. 2011305, 170-177 (invited, special issue honoring Catherine E. Costello) [pdf].
46. HJ Yoo, K Håkansson. Determination of Phospholipid Regiochemistry by Ag(I) Adduction and Tandem Mass Spectrometry. Anal. Chem. 201183, 1275-1283 [pdf].
45. TJ Buchholz, CM Rath, NB Lopanik, NP Gardner, K Håkansson, DH Sherman. Polyketide ?Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase. Chem. Biol. 201017, 1092-1100 [pdf].
44. D Khare, B Wang, L Gu, J Razelun, DH Sherman, WH Gerwick, K Håkansson, JL Smith. Crystal Structure of the Halogenase Domain in Curacin A Biosynthesis: Conformational Switch Triggered by a-Ketoglutarate. Proc. Natl. Acad. Sci. U.S.A. 2010107, 14099-14104 [pdf].
43. HJ Yoo, K Håkansson. Determination of Double Bond Location in Fatty Acids by Manganese Adduction and Electron Induced Dissociation. Anal. Chem. 201082, 6940-6946 [pdf].
42. A Kalli, K Håkansson. Electron Capture Dissociation of Highly Charged Proteolytic Peptides from Lys N, Lys C and Glu C Digestion. Mol. Biosyst. 20106, 1668-1681 (invited, special issue on Emerging Investigators) [pdf].
41. M Yoon, H Song, K Håkansson, ENG Marsh. Hydrogen Tunneling in Adenosylcobalamin-Dependent Glutamate Mutase: Evidence from Intrinsic Kinetic Isotope Effects Measured by Intra-molecular Competition. Biochemistry 201049, 3168-3173 [pdf].
40. JS Matson, HJ Yoo, K Håkansson, VJ DiRita. Polymyxin B Resistance in El Tor Vibrio cholerae Requires Lipid Acylation Catalyzed by MsbB. J. Bacteriol. 2010192, 2044-2052 [pdf].
39. K Håkansson, JS Klassen. Ion Activation Methods for Tandem Mass Spectrometry. In Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications; Cole, R. B. Ed.; John Wiley & Sons: New York, 2010; pp 571-630.
38. L Gu, B Wang, A Kulkarni, JJ Gehret, K Lloyd, L Gerwick, WH Gerwick, P Wipf, K Håkansson, JL Smith, DH Sherman. Polyketide Decarboxylative Chain Termination Preceded by O-Sulfonation in Curacin A Biosynthesis. J. Am. Chem. Soc. 2009131, 16033-16035 [pdf].
37. CY Majmudar, B Wang, JK Lum, K Håkansson, AK Mapp. A High Resolution Interaction Map of Three Transcriptional Activation Domains with an Essential Co-activator from Photo Cross-Linking and Multiplexed Mass Spectrometry. Angew. Chem. Int. Ed. 2009, 48, 7021-7024 (selected as VIP) [pdf].
36. J Yang, K Håkansson. Tandem Mass Spectrometry of Nucleic Acids. In Mass Spectrometric Determination and Study of DNA and RNA; Banoub, J. H.; Limbach, P. A. Eds.; CRC Press: Boca Raton, 2009; pp 95-116.
35. L Gu, B Wang, A Kulkarni, TW Geders, RV Grindberg, LG Gerwick, K Håkansson, P Wipf, JL Smith, WH Gerwick, DH Sherman. Metamorphic Enzyme Assembly in Polyketide Diversification.Nature 2009, 459, 731-735 [pdf].
34. J Yang, K Håkansson. Characterization of Oligodeoxynucleotide Fragmentation Pathways in Infrared Multiphoton Dissociation and Electron Detachment Dissociation by Fourier Transform Ion Cyclotron Double Resonance. Eur. J. Mass Spectrom. 2009, 15, 293-304 (invited, special issue honoring Peter J. Derrick) [abstract].
33. JJ Mo, GC Todd, K Håkansson. Characterization of Nucleic Acid Higher Order Structure by Gas-Phase H/D Exchange in a Quadrupole-FT-ICR Mass Spectrometer. Biopolymers 2009, 91, 256-264 (invited, special issue dedicated to advances in the investigation of nucleic acids and nucleic acid assemblies) [pdf].
32. S Wilson-Stanford, A Kalli, K Håkansson, J Kastrantas, RS.Orugunty, E Breukink, L Smith, L. Oxidation of Lanthionines Renders the Lantibiotic Nisin Inactive. Appl. Environ. Microbiol. 2009, 75, 1381-1387 [full text].
31. MA Ditzler, D Rueda, JJ Mo, K Håkansson, NG Walter. A Rugged Free Energy Landscape Separates Multiple Functional RNA Folds Throughout Denaturation. Nucleic Acids Res. 2008, 36, 7088-7099 [pdf].
30. NB Lopanik, JA Shields, TJ Buchholz, CM Rath, J Hothersall, MG Haygood, K Håkansson, CM Thomas, DH Sherman. In vivo and in vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont. Chem. Biol. 200815, 1175-1186 [pdf].
29. J Yang, K Håkansson. Characterization and Optimization of Electron Detachment Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Int. J. Mass Spectrom. 2008, 276, 144-148 (invited) [pdf].
28. A Kalli, K Håkansson. Comparison of the Electron Capture Dissociation Fragmentation Behavior of Doubly- and Triply-protonated Peptides from Trypsin, Glu-C and Chymotrypsin Digestion. J. Proteome Res. 20087, 2834-2844 [pdf].
27. HC Liu, HJ Yoo, K Håkansson. Characterization of Phosphate-Containing Metabolites by Calcium Adduction and Electron Capture Dissociation. J. Am. Soc. Mass Spectrom. 200819, 799-808 (invited) [pdf].
26. HK Kweon, K Håkansson. Metal Oxide-Based Enrichment Combined with Gas-Phase Ion-Electron Reactions for Improved Mass Spectrometric Characterization of Protein Phosphorylation. J. Proteome Res. 2008, 7, 745-755 [pdf].
25. T Geders, L Gu, JC Mowers, HC Liu, WH Gerwick, K Håkansson, DH Sherman, JL Smith. Crystal Structure of the ECH2 Catalytic Domain of CurF from Lyngbya majuscula: Insights into a Decarboxylase Involved in Polyketide Chain ?branching. J. Biol. Chem. 200782, 35954?5963 [pdf].
24. JT Adamson,K Håkansson. Electron Detachment Dissociation of Neutral and Sialylated Oligosaccharides.  J. Am. Soc. Mass Spectrom. 200718, 2162-2172 [fulltext].
23. IJ Goldstein, HC Winter, J Aurandt, L Confer, JT Adamson, K Håkansson, H Remmer. A New a-Galactosyl-Binding Protein from the Mushroom Lyophyllum decastes. Arch. Biochem. Biophys.2007467, 268-274 [pdf].
22. L Gu, TW Geders, B Wang, WH Gerwick, K Håkansson, JL Smith, DH Sherman. GNAT-Like Strategy for Polyketide Chain Initiation. Science 2007318, 970-974 [pdf].
21. M Yoon, A Kalli, HY Lee, K Håkansson, ENG Marsh. Intrinsic Deuterium Kinetic Isotope Effects in Glutamate Mutase Measured by an Intramolecular Competition Experiment. Angew. Chem. Int. Ed. 200746, 8455-8459 [pdf].
20. H Liu, K Håkansson. Abundant b-Type Ions Produced in Electron Capture Dissociation of Peptides without Basic Amino Acid Residues.  J. Am. Soc. Mass Spectrom. 200718, 2007-2013[fulltext].
19. J Mo, K Håkansson. Oligonucleotide Gas-Phase Hydrogen/Deuterium Exchange with D2S in the Collision Cell of a Q-FT-ICR Mass Spectrometer. Anal. Chem.200779, 7893-7898 [pdf].
18. HJ Yoo, HC Liu, K Håkansson. Infrared Multiphoton Dissociation and Electron-Induced Dissociation as Alternative MS/MS Strategies for Metabolite Identification. Anal. Chem. 200779, 7858-7866 [pdf].
17. JT Adamson, K Håkansson. Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Lectin Analysis. In Lectins: Analytical Technologies. Nilsson, C. L. Ed.; Elsevier: Amsterdam, 2007, 343-371.
16. H Liu, JY Lee, DH Sherman, K Håkansson. Collision Activated Dissociation, Infrared Multiphoton Dissociation, and Electron Capture Dissociation of the Bacillus anthracis Siderophore Petrobactin and its Metal Ion Complexes. J. Am. Soc. Mass Spectrom2007, 18, 842-849 [pdf].
15. JT Adamson, K Håkansson. Electron Capture Dissociation of Oligosaccharides Ionized with Alkali, Alkaline Earth, and Transition Metals. Anal. Chem. 2007, 79, 2901-2910 [pdf].
14. A Kalli, K Håkansson. Preferential Cleavage of S-S and C-S Bonds in Electron Detachment Dissociation and Infrared Multiphoton Dissociation of Disulfide-Linked Peptide Anions. Int. J. Mass Spectrom. 2007, 263, 71-81 [fulltext].
13. JY Lee, BK Janes, KD Passalacqua, B Pfleger, NH Bergman, H Liu, K Håkansson, RV Somu, CC Aldrich, S Cendrowski, P Hanna, DH Sherman. Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillus anthracis. J. Bacteriol. 2007, 189, 1698-1710 [pdf].
12. H Liu, K Håkansson. Divalent Metal Ion-Peptide Interactions Probed by Electron Capture Dissociation of Trications. J. Am. Soc. Mass Spectrom. 2006, 17, 1731-1741 [fulltext].
11. H Liu, K Håkansson. Electron Capture Dissociation of Tyrosine O-Sulfated Peptides Complexed with Divalent Metal Cations. Anal. Chem. 2006, 78, 7570-7576 [pdf].
10. J Yang, K Håkansson. Fragmentation of Oligoribonucleotides from Gas-Phase Ion-Electron Reactions. J. Am. Soc. Mass Spectrom. 2006, 17, 1369-1375 (invited) [pdf].
9. J Mo, K Håkansson. Characterization of Nucleic Acid Higher Order Structure by Tandem High Resolution Mass Spectrometry. Anal. Bioanal. Chem. 2006, 386, 675-681 (invited) [pdf].
8. L Gu, J Jia, H Liu, K Håkansson, WH Gerwick, DH Sherman. Metabolic Coupling of Dehydration in the Curacin A Pathway: Functional Identification of a Mechanistically Diverse Enzyme Pair. J. Am. Chem. Soc. 2006, 128, 9014-9015 [pdf].
7. HK Kweon, K Håkansson. Selective Zirconium Dioxide-Based Enrichment of Phosphorylated Peptides for Mass Spectrometric Analysis. Anal. Chem. 2006, 78, 1743-1749 (accelerated article) [pdf].
6. JT Adamson, K Håkansson. Infrared Multiphoton Dissociation and Electron Capture Dissociation of High-Mannose Type Glycopeptides. J. Proteome Res. 2006, 5, 493-501 [pdf].
5. HK Kweon, K Håkansson. Site-specific amide hydrogen exchange in melittin probed by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry. Analyst.2006131, 275-280 (invited) [pdf].
4. J Yang, J Mo, JT Adamson, K Håkansson. Characterization of Oligodeoxynucleotides by Electron Detachment Dissociation Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.Anal. Chem. 200577, 1876-1882 [pdf].
3. HJ Cooper, K Håkansson, AG Marshall. The Role of Electron Capture Dissociation in Biomolecular Analysis. Mass Spectrom. Rev. 2005, 24, 201-222 [pdf].
2. KN Schultz, K Håkansson. Rapid Electron Capture Dissociation of Mass-Selectively Accumulated Oligodeoxynucleotide Dications. Int. J. Mass Spectrom. 2004, 234, 123-130 [pdf].
1. TW Hurd, S Fan, CJ Liu, HK Kweon, K Håkansson, B Margolis. Phosphorylation-Dependent Binding of 14-3-3 to the Polarity Protein Par3 Regulates Cell Polarity in Mammalian Epithelia. Curr. Biol.2003, 13, 2082-2090 [fulltext].