Publications – Transcription Factor Interactions

· Ramirez-Carrozzi, VR and Kerppola, TK: gelFRET analysis of nucleoprotein complexes. Methods 25: 2001

· Ramirez-Carrozzi, V. R. and Kerppola, T. K. Control of the orientation of Fos-Jun binding and the transcriptional cooperativity of Fos-Jun–NFAT1 complexes. J. Biol. Chem. 276:21797-21808, 2001. [Abstract] [Full text] [PDF]

· Chinenov, Y and Kerppola, TK: Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity. Oncogene 20:2438-2452, 2001. [Abstract] [Full text] [PDF]

· Ramirez-Carrozzi, VR and Kerppola, TK: Dynamics of Fos-Jun-NFAT1 complexes. Proc. Natl. Acad. Sci. U.S.A. 98:4893-4898, 2001. [Abstract] [Full text] [PDF]

· Dlakic M, Grinberg, AV, Leonard, DA and Kerppola, TK: DNA sequence-dependent folding determines the divergence in binding specificities between Maf and other bZIP proteins. EMBO Journal 20: 828‑840, 2001. [Abstract] [Full text] [PDF]

· Ramirez-Carrozzi, VR and Kerppola, TK: Long-range electrostatic interactions influence the orientation of Fos-Jun binding at AP-1 sites. J. Mol. Biol. 305: 411-427, 2001. [Abstract] [Full text] [PDF]

· Kerppola, TK: Protein-DNA interactions: structure and energetics. Encyclopedia of Life Sciences, Macmillan Reference Ltd., 2001. [Home page]

· Kerppola, TK: Molecular architecture and dynamics of transcription-regulatory protein complexes. HHMI Research in Progress, 2001. [Full text]

· Leonard, DA and Kerppola, TK: DNA bending determines Fos-Jun heterodimer orientation. Nature Structural Biology, 5:877-881, 1998. [Abstract] [Full text] [PDF]

· Kerppola, TK: Transcriptional cooperativity: bending over backwards and doing the flip. Structure, 6:549-554, 1998. [Abstract] [Full text] [PDF]

· Diebold, RJ, Rajaram, N, Leonard, D.A and Kerppola, TK: Molecular basis of cooperative DNA bending and oriented heterodimer binding in the NFAT1-Fos-Jun-ARRE2 complex. Proc. Natl. Acad. Sci. U.S.A., 95:7915-7920, 1998. [Abstract] [Full text] [PDF]

· Kerppola, TK: Molecular architecture of transcription factor complexes. HHMI Research in Progress, p. 339-340, 1997-1998. [Full text]

· Rajaram, N and Kerppola, TK: DNA bending by Fos-Jun and the orientation of heterodimer binding depend on sequence of the AP-1 site. EMBO J, 16:2917-2926, 1997. [Abstract] [Full Text] [PDF]

· Kerppola, TK and Curran, T: The transcription activation domains of Fos and Jun induce DNA bending through electrostatic interactions. EMBO J, 16:2907-2916, 1997. [Abstract] [Full Text] [PDF]

· Leonard, D, Rajaram, N and Kerppola, TK: Structural basis of DNA bending and oriented heterodimer binding by Fos and Jun. Proc. Natl. Acad. Sci. U.S.A., 94:4913-4918, 1997. [Abstract] [Full Text] [PDF]

· Kerppola, TK: Comparison of DNA bending by Fos-Jun and phased A tracts by multifactorial phasing analysis. Biochemistry, 36:10872-10884, 1997. [Abstract] [Full Text] [PDF]

· Kerppola, TK: Molecular architecture of transcription factor complexes. HHMI Biennial Scientific Report, p. 76-77, 1996-1998.

· Penix, LA, Sweetser, MT, Weaver, WM, Hoeffler, JP, Kerppola, TK and Wilson, CB: The proximal regulatory element of the interferon-promoter mediates selective expression in T cells. J. Biol. Chem. 271:31964-31972, 1996. [Abstract] [Full Text] [PDF]

· Ito, K, Asano, M, Hughes, P, Kohzaki, H, Masutani, C, Hanaoka, F, Kerppola, TK, Curran, T, Murakami, Y and Ito, Y: c-Jun stimulates origin-dependent DNA unwinding by polyomavirus large T antigen. EMBO J, 15:5636-5646, 1996. [Abstract]

· Kerppola, TK: Fos and Jun bend the AP-1 site: Effects of probe geometry on the detection of protein induced DNA bending. Proc. Natl. Acad. Sci. U.S.A., 93: 10117-10122, 1996. [Abstract] [PDF]

· Kerppola, TK and Curran, T: Zen and the art of Fos and Jun. Nature, 373: 199-200, 1995.

· Robertson, LM, Kerppola, TK, Vendrell, M, Luk, D, Smeyne, RJ, Bocchiaro, C, Morgan, JI and Curran, T: Regulation of c-fos expression in transgenic mice requires multiple interdependent control elements. Neuron, 14: 241-252, 1995. [Abstract]

· Kerppola, TK and Curran, T: A conserved region adjacent to the domain is required for recognition of an extended DNA binding site by Maf/Nrl family proteins. Oncogene, 9 (11): 3149-3158, 1994.

· Yaseen, NR, Park, J, Kerppola, TK, Curran, T and Sharma, S: A central role for Fos in human B and T cell NFAT (Nuclear Factor of Activated T Cells): an Acidic Region is Required for In Vitro Assembly. Molecular and Cellular Biology, 14 (10): 6886-6895, 1994. [Abstract]

· Patel, LR, Curran, T and Kerppola, TK: Energy transfer analysis of Fos-Jun dimerization and DNA binding. Proc. Natl. Acad. Sci. USA, 91 (14): 7360-7364, 1994. [Abstract] [PDF]

· Kerppola, TK and Curran, T: Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun. Oncogene, 9 (3): 675-684, 1994.

· Hsu, W, Kerppola, TK, Chen, P-L, Curran, T and Chen-Kiang, S: Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Molecular and Cell Biology, 14 (1): 268-276, 1994. [Abstract]

· McCaffrey, PG, Luo, C, Kerppola, TK, Jain, J, Badalian, T, Ho, A, Burgeon, E, Lane, WS, Lambert, JN, Curran, T, Verdine, GL, Rao, A and Hogan, PG: : Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science, 262: 750-754, 1993.

· Jain, J, McCaffrey, PG, Miner, Z, Kerppola, TK, Lambert, JN, Verdine, GL, Curran, T and Rao, A: The T cell transcription factor NFATp is a substrate for calcineurin and interacts with the DNA-binding domains of Fos and Jun. Nature, 365 (6444): 352-355, 1993.

· Kerppola, TK and Curran, T: Selective DNA bending by a variety of bZIP proteins. Molecular and Cell Biology, 13 (9): 5479-5489, 1993. [Abstract]

· Kerppola, TK, Luk, D and Curran, T: Fos is a preferred target for glucocorticoid receptor inhibition of AP1 activity in vitro. Molecular and Cell Biology 13 (6): 3782-3791, 1993. [Abstract]

· Baker, SJ, Kerppola, TK, Luk, D, Vandenberg, MT, Marshak, DR, Curran, T and Abate, C: Jun is phosphorylated by several protein kinases at the same sites modified in serum stimulated fibroblasts. Molecular and Cell Biology, 12 (10): 4694-4705, 1992. [Abstract]

· Kerppola, TK and Curran, T: DNA bending by Fos and Jun: The flexible hinge model. Science, 254: 1210-1214, 1991.

· Kerppola, TK and Curran, T: Fos–Jun heterodimers and Jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity. Cell, 66: 317-326, 1991. [Abstract]

· Kerppola, TK and Curran, T: Transcription factor interactions: Basics on zippers. Current Opinion in Structural Biology, 1: 71-79, 1991.