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Maintained by Vishhvaan Gopalakrishnan
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THE HUNT LAB

Rapid Microtubule Self-Assembly Kinetics published in Cell

  BME Professor Alan J. Hunt has published a groundbreaking paper in the August 21, 2011 issue of Cell. The paper titled “Rapid Microtubule Self-Assemblly Kinetics” describes a multi-investigator effort growing from a collaboration between Professor Hunt’s own lab and Professor David Odde and his group at the Univeristy of Minnesota. This work fundamentally changes our understanding of how a critical cellular component, microtubules, are formed and regulated. In addition to fundamentally impacting our understanding of cell biology, it also has important implications for chemotherapy, as microtubule polymerization dynamics are one of the most important targets for anticancer drugs. The experimental work involves advanced technologies for nanometer-scale studies of microtubule polymerization, and computer modeling. The abstract and full article can be viewed online.

Recent News

Primary Investigator:

Alan J. Hunt, Ph.D.

 

Post-Graduate Students:

Blake Charlebois, Ph.D.

Cuie Chen, Ph.D.

Damon Hoff, Ph.D.

Aghapi Mordovanakis, Ph.D.

 

Graduate Students:

Seth McCubbin

Hong Zhou

 

Undergraduate Students:

Vishhvaan Gopalakrishnan

 

Collaborators:

Joe Bull, Ph.D.,

University of Michigan

Biomedical Engineering

 

Duane Compton, Ph.D.

Dartmouth University

Biochemistry Department

 

Holly Goodson, Ph.D.

University of Notre Dame

Chemistry and Biochemistry

Jay Guo, Ph.D.

University of Michigan

Electrical Engineering and Computer Science

 

Ernest C. Hasselbrink Jr., Ph.D.

University of Michigan

Mechanical Engineering

 

Charles Lindemann, Ph.D.

Oakland University

Biological Sciences

 

Michael Mayer, Ph.D.

University of Michigan

Biomedical Engineering

 

Edgar Meyhofer, Ph.D.

University of Michigan

Mechanical Engineering

 

David Odde, Ph.D.

University of Minnesota

Biomedical Engineering

 

 

Yukiko Yamahita, Ph.D.

University of Michigan

Life Sciences Institute

 

Alumni:

Ran An, Ph.D.

McMaster University

Post-doctoral Research Fellow

 

Matt Beneke

TomoTherapy Inc. in Madison, WI

 

Gary Brouhard, Ph.D.

McGill University

Assistant Professor

 

Jun Cheng, Ph.D.

University of Illinois

Bioengineering

 

Mindy Chilman

 

Leonard Chu

University of Michigan

Orthopaedics Research Laboratory

 

Elissa Cosgrove

Boston University

Gardner Laboratory

 

Jeff Herbstman, Ph.D.

University of Michigan

Skiniotis Laboratory

 

Diana Hilton

University of Michigan

Fierke Group

 

Ajit Joglekar, Ph.D.

University of North Carolina, Chapel Hill

Salmon Laboratory

 

Kevin Ke, Ph.D.

University of Michigan

Mohammed Islam Group

 

Shaun Kennedy

University of Michigan

Biophysics Program

 

Sanghyun Lee, Ph.D.

Pohang University of Science and Technology (POSTECH)

David Lorch, Ph.D.

Brown University

Life and Physical Sciences

 

Laura McIntyre

University of Michigan

Medical School

 

Pratik Rohatgi

University of Michigan

Medical School

 

Aaron Rury

University of Michigan

Sension Group

 

Henry T. Schek, III, Ph.D.

89 North

 

Eric Tkaczyk

University of Michigan

Medical School

 

 

 

Welcome

You have reached the website of the Cellular and Molecular Biomechanics Laboratory (CMBL) at The University of Michigan. Our laboratory investigates the physical and mechanical properties of the molecular motors that underlie biologic motility. We design and use systems for imaging and manipulating subcellular structures at the micro-and nano-meter level. Click on the links above to find out more about the CMBL or click here to visit the Biomedical Group at the Center for Ultrafast Optical Science (CUOS)

 

Lab Members in Picture: [Top] Blake Charlebois, Seth McCubbin, Damon Hoff, Aghapi Mordovanakis, Aslan Dizaji, [Bottom] Hong Zhou, Alan Hunt, Cuie Chen