ICBIC-12 Oral Program

ICBIC-12 Oral Presentation Schedule

Sunday, July 31, 2005

Parallel sessions

1:00 PM	Newton, William E. Some Insights into How Nitrogenase Works
1:30 PM	Münck, Eckard Mossbauer and EPR Studies of Nitrogenase
2:00 PM	Holm, Richard H. Chemical Approaches to Complex Heterometalsulfur Sites in Biology
2:30 PM	Pickett, Chris Interactions of small molecules at isolated FeMoco : relic chemistry of an ancient enzyme ?
3:00 PM	Seefeldt, Lance Insights Into the Nitrogenase Mechanism
3:30 PM	Hoffman, Brian EPR and ENDOR Characterization of Nitrogenase Enzymatic Intermediates

Monday, August 01, 2005
Plenary Lecture 9:00 AM
Meade, Thomas
Visualizing cell fate: Bioactivated-multimodal probes for imaging stem cells, b-islets and cancer

Parallel sessions

10:35 AM	Raymond, Kenneth Toward High Relaxivity and High Stability in Gd MRI Agents	Michibata, Hitoshi Vanadium in Biology: Accumulation Mechamism in Ascidians	Milaeva, Elena The role of radical processes in the toxicity mechanism of organomercurials and organotins	Britt, David Pulsed EPR Studies of PSII Oxygen Evolution
11:10 AM	Aime, Silvio Exploring routes for Cellular and Molecular Magnetic Resonance Imaging with Paramagnetic Lanthanide Complexes	Butler, Alison The Reactivity of Vanadium Bromoperoxidase in the Biosynthesis of Halogenated Marine Natural Products	Messens, Joris Arsenate reductase, a small, almost universal, protein that uses a cysteine thiol cascade for redox chemistry	Messinger, Johannes 55Mn Pulse ENDOR and X-Ray Absorption Spectroscopy Studies into the Electronic and Geometric Structures of the Oxygen-Evolving Complex in Photosystem II
11:45 AM	Welch, Michael Radioactive Metal Complexes as Agents for Positron Emission Tomography	Bühl, Michael Computational Chemistry of Vanadate Complexes with Biogenic Ligands: Structure, Properties, and Reactivities	Giedroc, David Coordination Chemistry of Metal Sensing Sites and Allosteric Switching in Metal-responsive Transcriptional Regulators	Siegbahn, Per The mechanism for dioxygen formation in PSII studied by quantum chemical methods

Parallel sessions

2:05 PM	Meares, Claude Advances in infinite binding of proteins to targets	Moura, Jose J. G. Mo and W Enzymes: Nitrate Reductases and Formate Dehydrogenases	Schaffner, Walter Copper and other heavy metals: from insects to mammals	Popot, Jean-Luc Why does the b6f complex comprise three more cofactors than cytochrome bc1?
2:40 PM	Therien, Michael In Vivo Optical Imaging Enabled by Soft-Matter Analogues of the Quantum Dots	Enemark, John H. Spectroscopic studies of the molybdenum centers of enzymes and related model compounds	Robinson, Nigel John ArsR-SmtB metal-sensing transcriptional-repressors	Gennis, Robert The Proton Pump of Cytochrome Oxidase
3:15 PM	Lippard, Stephen J. Zinc and Nitric Oxide Imaging in the Brain	Schwarz, Guenter Molybdenum Cofactor Biosynthesis: The Mechanism of Metal Transfer to Molybdopterin Involves Copper	Summers, Anne Genetic and Biophysical Insights into How MerR Distinguishes Hg(II), Cd(II), and Zn(II)	Wikstrom, Marten Gating of water and proton transfer in the respiratory enzyme
3:50 PM	Fahrni, Christoph J. Rational Design of Fluorescence Sensors for the Biological Chemistry of Copper	Schindelin, Hermann Molybdenum Cofactor Biosynthesis	Zamble, Deborah The Metal-Selective Response of the Escherichia coli Nickel Metalloregulator NikR	Naruta, Yoshinori Modeling Study of Oxygen Activation in Cytochrome c Oxidase: Roles of Residues at the Active Site

Tuesday, August 02, 2005
Plenary Lecture 9:00 AM
Luchinat, Claudio
Evolution - and Involution - of Calcium Signaling

Parallel sessions

10:35 AM	Guo, Zijian From Mechanistic Study to the Design of Platinum-Based Anticancer Complexes	Peters, John The Role of MgATP Binding in Nitrogenase Catalysis	Vaillancourt, Frederic H. A novel non-heme Fe(II) alpha-ketoglutarate-dependent chlorinating enzyme in syringomycin E biosynthesis	Winge, Dennis Compartmentalization of copper used in assembly of cytochrome c oxidase within the mitochondrion
11:10 AM	Keppler, Bernhard K. New anti-tumor active metal compounds	Hinnemann, Berit The enzyme nitrogenase and its catalysis: Biological ammonia synthesis and hydrogen production	Drennan, Cathy Structural Insight into Antibiotic Fosfomycin Biosynthesis by a Mononuclear Iron Enzyme	Bertini, Ivano A Bioinformatic/Structural biology approach to explore biochemical paths. The case of copper in cytochrome c oxidase assembling
11:45 AM	Brewer, George Copper and Copper Lowering Therapy in Medicine	Tatsumi, Kazuyuki Synthesis of Iron/Sulfur Clusters in Non-Polar Solvents - Toward Better Clusters Modeling the Nitrogenase Active Sites	Krebs, Carsten Oxygen Activation by the alpha--Ketoglutarate-Dependent Dioxygenases	Böck, August Assembly of the metal center of [NiFe]-hydrogenases

Parallel sessions

2:05 PM	Ng, Dennis K. P. New Phthalocyanines as Efficient Photosensitizers for Photodynamic Therapy	Hammarström, Leif Biomimetic Approaches to Artificial Photosynthesis	Que, Lawrence Oxygen Activation at Nonheme Iron. New Features of the Oxoiron(IV) Landscape	Dean, Dennis Biochemical-genetic analysis of [Fe-S] cluster biosynthesis in Azotobacter vinelandii
2:40 PM	Hambley, Trevor Can Platinum(IV) Anti-Cancer Agents be Selectively Activated in Tumours?	Gray, Harry B. Wiring Redox Enzymes	Niviere, Vincent Detoxification of Superoxide Radical by Reduction. Reaction Mechanism of Superoxide Reductase SOR	Netz, Daili J. A. The Cytosolic Iron-Sulfur protein Assembly machinery: Characterization of the Cfd1p-Nbp35p complex
3:15 PM	Egan, Tim Exploring the Solution Structures of Heme-Quinoline Complexes and their Relation to Antimalarial Activity	Fukuzumi, Shunichi Bioinspired Electron Transfer Catalytic Systems	Kovacs, Julie A Functional Model for the Non-Heme Iron Enzyme Superoxide Reductase (SOR)	Ollagnier, Sandrine Biosynthesis of Iron-Sulfur Clusters :the Peculiar Properties of the A-type Scaffold Proteins
3:50 PM	Barba-Behrens, Norah Towards chiral coordination compounds with ephedrine and pseudoephedrine derivatives. On the Cu(II)---HC agostic interaction?	Crane, Brian Interprotein electron transfer in single crystals	Eltis, Lindsay The ins and outs of ring-cleavage dioxygenases: insights from novel spectroscopic approaches	Stemmler, Timothy Structural Implications into Frataxin's Role in Heme and Iron-Sulfur Cluster Biosynthesis

Wednesday, August 03, 2005
Plenary Lecture 8:30 AM
Theil, Elizabeth C.
The Ferritin Fe and O Stories: Protein, genes and mRNA

Parallel sessions

10:35 AM	Camakaris, James Regulation of Function of the Menkes copper transporting P-type ATPase-role in health and disease	English, Ann Copper in the Transduction of NOx-derived Signals: Mechanisms and Biological Implications	Tommos, Cecilia Redox Properties of Tryptophan and Tyrosine: Effects of the Protein Matrix	Chapman, Stephen Multi-heme Cytochromes: New Folds, New Ligation, New Chemistry.
11:10 AM	Bush, Ashley Copper And Zinc Interaction with Alzheimer's Disease beta-Amyloid	Aono, Shigetoshi Molecular Mechanism of Functional Regulation for the Heme-Based Sensor Proteins	Berg, Jeremy Metal-Binding Domains: Designing Specific Single-Stranded Nucleic Acid- and Peptide-Binding Domains	Romão, Maria João Multiheme (type c) membrane bound nitrite reductase from Desulfovibrio desulfuricans ATCC 27774: The relevance of the two calcium sites in the catalytic subunit.
11:45 AM	Valentine, Joan What Makes ALS-Mutant Copper-Zinc Superoxide Dismutase Toxic?	Kitagawa, Teizo Effects of YC-1 and GTP on NO-bound Heme Structure of Soluble Gyanylyl Cyclase	McLendon, George "Pair up in Threes" Functional Design Strategies for Metal Assembled Modular Proteins	Elliott, Sean Electrochemical studies of heme enzymes and proteins: bacterial peroxidases and cytochromes c

Thursday, August 04, 2005
Plenary Lecture 9:00 AM
Toyoshima, Chikashi
Ion pumping by calcium ATPase of sarcoplasmic reticulum : a structural perspective

Parallel sessions

10:35 AM	Banerjee, Ruma Radical Enzymes and their Escorts	Ikeda-Saito, Masao Molecular Mechanism of Heme Oxygenase Catalysis	Bruseth, Live J. Copper homeostasis in Methylococcus capsulatus	Douglas, Trevor Protein cages architectures: biomineralization, nucleic acid encapsidation, and applications in nanoscience
11:10 AM	Brunold, Thomas C. Spectroscopic/Computational Insights into the Biosynthesis and Reactivity of Coenzyme B12	Yoshizawa, Kazunari A New Mechanism for the Function of Heme Oxygenase	Wedd, Anthony The CopC Protein from Pseudomonas syringae: Intermolecular Transfer of Copper Occurs from Both the Copper(I) and Copper(II) Sites	Bittner, Alexander Composites of Tobacco Mosaic Virus with Metal Clusters and Wires
11:45 AM	Warncke, Kurt Structure and Dynamics in B12-Dependent Enzyme Catalysis	Dawson, John H. Reactivity of Transient Cytochrome P450 Oxygen Intermediates	O'Halloran, Thomas Inorganic Battlegrounds in Infectious Disease: Zinc and Iron Chemistry of Malaria Parasite	Powell, Annie Modeling Calcium Carbonate Biomineralization Processes

Parallel sessions

2:05 PM	Wieghardt, Karl The Electronic Structure of Complexes with Coordinated Organic Radicals	Nam, Wonwoo Oxoiron(IV) Porphyrin Cation Radical Complexes with a Chameleon Behavior in Cytochrome P450 Model Reactions	Eitinger, Thomas Transporters for Nickel and Cobalt - Experimental Evidence and Comparative Genomic Analyses	Vila, Alejandro Jose Diversity, evolution and mechanism of zinc beta-lactamases
2:40 PM	Stubbe, JoAnne Ribonucleotide Reductases: Use of Unnatural Amino Acids to Understand the Radical Initiation Process.	Ghosh, Abhik Understanding and Computing Metalloporphyrin Electronic Structures: From an Alkyl/Aryl/NO Isolobal Analogy to Failures of DFT for High-Valent Iron Porphyrins	Coves, Jacques Bacterial mercury resistance : metal trafficking and regulation	Vasak, Milan Zinc in the brain: unravelling the role of Zn-metallothionein-3
3:15 PM	Ivancich, Anabella Protein-based Radical Intermediates in bi-functional heme peroxidases	Goldberg, David Stable Porphyrinoid Mn(V)-Oxo Species Capable of Oxygen Atom Transfer and Hydrogen Atom Abstraction	Mercer, Julian The Role of Trafficking of Cu-ATPases in mammalian copper homeostasis	Parkin, Gerard Synthetic Analogues of Zinc Enzymes with Sulfur-Rich Active Sites
3:50 PM	Dooley, David Sturucture and Reactivity of Type 2 Copper Oxidases	Bominaar, Emile Mössbauer , XANES and DFT characterization of an aqueous FeIV=O species	Kosman, Daniel Structure of the Yeast Ferroxidase, Fet3p: Implications for Function	Ellis, Paul Zinc and Magnesium Low Temperature Solid-State NMR Spectroscopy of Metalloproteins

Friday, August 05, 2005
Plenary Lecture 9:00 AM
Fontecave, Marc
Iron and Sulfur : a Reactive Bioinorganic Combination

Parallel sessions

10:35 AM	Murphy, Michael A Copper Nitrosyl in Nitrite Reductase	Huynh, Boi Hanh (Vincent) Site-specific Fe4S4 Chemistry in Ferredoxin:Thioredoxin Reductase	Sigel, Helmut Nucleobases. Their Acid-Base and Metal Ion-Binding Properties	Thauer, Rudolf K The mononuclear iron active site of the iron-sulfur-cluster-free hydrogenase (Hmd)
11:10 AM	Itoh, Shinobu Kinetic Evaluation of Dioxygen Activation Mechanism by Dicopper Enzymes	Bennati, Marina 57Fe ENDOR Spectroscopy on the Iron-Sulfur Cluster Involved in Substrate Reduction of Heterodisulfide Reductase	Sigel, Roland K. O. Structure of the Branchpoint Domain 6 in a Group II Intron Ribozyme	Armstrong, Fraser Hydrogenases on Electrodes:Revealing and Elucidating their Complex Chemistry
11:45 AM	Rosenzweig, Amy Crystal structure of particulate methane monooxygenase	Case, David Analysis of spin-spin interactions in transition metal clusters of biochemical interest	DeRose, Victoria Metal Interactions with Structured and Catalytic RNA Molecules	Rauchfuss, Thomas Ferrous Thiolato Carbonyls and Their Connection to the Fe-only Hydrogenases

Parallel sessions

2:05 PM	Stack, Daniel Tyrosinase Reactivity in a Model Complex: An Alternative Hydroxylation Mechanism	Jarrett, Joseph The Role of a [2Fe-2S]2+ Cluster in Carbon-Sulfur Bond Formation as Catalyzed by Biotin Synthase	Neves, Ademir Unsymmetrical Dinuclear [Fe(III)(mu-OH)M(II)] (M(II) = Zn, Cu) Complexes as Artificial Metallohydrolases	Lindahl, Paul Mechanism of Acetyl-CoA Synthase/Carbon Monoxide Dehydrogenase: a Bifunctional Enzyme with Ni-Fe-S Active Sites Connected by a Tunnel Network
2:40 PM	Karlin, Kenneth D. Synthetic Modeling of the Heme-Copper Active Site O2-Reactivity	Hirst, Judy Proton-coupled electron transfer reactions at Rieske [2Fe-2S] clusters: three oxidation states and four protonation states.	Lippert, Bernhard Artificial Metal-Nucleobase Squares and their Interactions with Oligonucleotides, DNA and Simple Anions	Dobbek, Holger Aerobic and anaerobic life on carbon monoxide
3:15 PM	Solomon, Edward O2 and N2O activation by binuclear, trinuclear, and tetranuclear copper clusters	Barton, Jacqueline DNA-mediated Charge Transport in DNA Repair	Bierbach, Uli Adenine Recognition by Minor-Groove Targeted Platinum-Intercalator Conjugates: A New Technology with Applications in Chemotherapy and Gene Regulation	Riordan, Charles Synthetic Chemistry and Chemical Precedents for Understanding the Structure and Function of Acetyl Coenzyme A Synthase

Plenary Lecture 4:20 PM
Tolman, William
Using Synthetic Chemistry to Understand Copper Protein Active Sites