Biophysical and Physical Inorganic Chemistry
Spectroscopic investigation of metal site
structure in bioinorganic systems. There is a large group of enzymes
(including methionine synthase and farnesyl transferase) in which a Zn active
site is intimately involved in transfer of an alkyl group from an alkyl donor
to a thiol acceptor. We are interested in understanding the detailed
mechanism of these enzymes.
Development of new techniques in x-ray spectroscopy. X-ray spectroscopy is one of the premier methods for determining the local site structure of metal ions in biological systems. In addition to using established x-ray spectroscopic methods, we are interested in developing new methods, including the use of polarization properties to study the physical basis of x-ray absorption edge structure, the correlation of optical and x-ray absorption properties of metal ions, and the relationship of these properties to metal-ion electronic structure. Recent work has focused on high-resolution x-ray emission spectroscopy.
In situ study of metal speciation in biological tissue. In order to fully understand the function of metal ions in biological systems, it is necessary to know both the localization and the speciation off the metal ions, part of the new field of inorganic physiology. Current interests involve the distribution of metals in red blood cells infected with malaria and the distribution of metals in the hippocampus.
Links of Interest
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One of the main techniques used in our research is x-ray absorption spectroscopy
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