Cancer Detection & Therapy
with Medical Nanodevices
biomedical nanoparticles have been developed and applied
for in-vivo MRI (magnetic resonance imaging)
enhancement and photodynamic therapy (PDT) of a rat
implanted human brain tumor (9L glioma).
The nano-particles have a
polyacrylamide (PAA) core containing Photofrin as
photosensitizer, iron oxide as MRI contrast agent and F3
peptide as molecular targeting group for the recognition
of the tumor neovasculature. The tumor targeting and PDT
efficacy of the nanoparticles were monitored by MRI after
the intravenous injection of the nanoparticles. The MRI
enhancement was observed and extended over 22 hours post
injection for targeted nanoparticles. A
single iv injection of a targeted therapeutic nanoparticle
dose, coupled with a single 5 min PDT treatment, leads not
only to an increase in the rat survival rate but
accomplishes complete tumor remission.
A flexible platform for the detection and treatment of cancer.