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bulletCancer Detection & Therapy with Medical Nanodevices

Multifunctional, biomedical nanoparticles have been developed and applied for in-vivo MRI (magnetic resonance imaging) enhancement and photodynamic therapy (PDT) of a rat implanted human brain tumor (9L glioma). The nano-particles have a polyacrylamide (PAA) core containing Photofrin as photosensitizer, iron oxide as MRI contrast agent and F3 peptide as molecular targeting group for the recognition of the tumor neovasculature.  The tumor targeting and PDT efficacy of the nanoparticles were monitored by MRI after the intravenous injection of the nanoparticles. The MRI enhancement was observed and extended over 22 hours post injection for targeted nanoparticles. A single iv injection of a targeted therapeutic nanoparticle dose, coupled with a single 5 min PDT treatment, leads not only to an increase in the rat survival rate but accomplishes complete tumor remission.


A flexible platform for the detection and treatment of cancer.


 

 

 

 

 

 

 

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