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bulletEnter PEBBLEs

Probes Encapsulated By Biologically Localized Embedding (PEBBLEs) are isolated nanoscale devices for intracellular chemical analysis. This schematic shows a generalized view of an ideal PEBBLE with many options for encapsulated constituents. Three different matrices are commonly used depending on the sensor materials. The diagram on the right shows the common combinations using these materials. In the examples that follow, it will become clear how this technology allows us to probe the nanoscale chemical and biological world.


   Three most common 
     matrix materials. 


Schematic of a general PEBBLE nanosensor. PEBBLE sizes can range from 20 to 200 nm in diameter.


Topics
Analytic Summary
Nano-Scale Analysis
Fiber-Optic Roots
Enter PEBBLEs
Oxygen PEBBLE Example
Ratiometric Device
Response & Interference
Quantitative Imaging
Delivery Methods
Gene Gun
Liposomal
PEBBLE Production
Wet Chemistry Method
PEBBLE Sizes
Surface Modification
Decyl Methacrylate Example
Fabrication
Response
Nitric Oxide Sensing
cGMP Cycle
Lifetime Detection



 

 

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