| Probes Encapsulated By Biologically
Localized Embedding (PEBBLEs) are isolated nanoscale
devices for intracellular chemical analysis. This
schematic shows a generalized view of an ideal PEBBLE
with many options for encapsulated constituents. Three
different matrices are commonly used depending on the
sensor materials. The diagram on the right shows the
common combinations using these materials. In the
examples that follow, it will become clear how this
technology allows us to probe the nanoscale chemical and
biological world. |

Three most common
matrix materials.
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