 MOONs
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MOONs are microscopic photonic
probes that look like moons: their northern hemisphere
appears bright and is colored with a fluorescent
indicator dye whose color reports on the local chemical
environment; the other side is darkened with an opaque
metal layer. They rotate in response to thermal
fluctuations in a fluid (Brownian MOONs) and to rotating
magnetic fields (MagMOONs), blinking as they turn
through the phases of the moon. The blinking stands out
against the background like a lighthouse against city
lights allowing sensitive chemical analysis from
microscopic probes. The probes have applications for
ultrasensitive ion and small molecule sensors within
cells, and robust sensitive immunoassays in blood and
other fluid samples. |
A 4.4 micron fluorescent MagMOON
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MOON References:
2005
B.H. McNaughton, V.A. Stoica, J.N.
Anker,
R. Clarke, and R.
Kopelman, “Fabrication
of uniform half-shell magnetic nanoparticles and
microspheres with applications as magnetically modulated
optical nanoprobes,” Posted on arxiv.org
(2005).
J.N. Anker, C.J. Behrend, and R.
Kopelman., "Magnetically-modulated
optical nanoprobes (MagMOONs) and systems," J. Magn.
Magn. Mater. 293, 655 (2005).
C.J.
Behrend,
J.N.
Anker,
B.H.
McNaughton,
R.
Kopelman, “Microrheology
with modulated optical nanoprobes (MOONs),” Journal
of Magnetism and Magnetic Materials 293, 663-670
(2005).
B.H. McNaughton,
J.N.
Anker,
R.
Kopelman, “Magnetic
microdrill as a modulated fluorescent pH sensor,”
Journal of Magnetism and Magnetic Materials 293,
696-701 (2005).
T.G. Roberts, , J.N. Anker, R.
Kopelman., "
Magnetically modulated optical nanoprobes (MagMOONs) for
detection and measurement of biologically important ions
against the natural background fluorescence of intracellular
environments," J. Magn. Magn. Mater. 293,
715 (2005).
2004
R.R.
Agayan,
T.
Horvath,
B.H. McNaughton,
J.N.
Anker, R. Kopelman, “Optical
manipulation of metal-silica hybrid nanoparticles,”
Procedings of SPIE. 5514, 502-513 (2004).
C.J. Behrend, J.N.
Anker,
B.H. McNaughton,
T.G. Roberts, M. Brasuel, M.A. Philbert,
R. Kopelman, “Metal-capped
brownain and magnetically modulated optical nanoprobes (MOONs):
micromechanics in chemical and biological
microenvironments,” Journal of Physical Chemistry B
108, 10408-10414 (2004).
C.J. Behrend, J.N.
Anker, R. Kopelman, "Brownian
modulated optical nanoprobes," Appl. Phys. Lett. 93,
6698-6700 (2004)
J.N. Anker, C.J.
Behrend,
B.H. McNaughton,
T.G. Roberts, M. Brasuel,
M.A. Philbert, “Characterization
and applications of modulated optical nanoprobes (MOONs)”
Mat. Res. Soc. Symp. Proc. 790, 4.4.1-12,
(2004).
2003
J.N. Anker, C. Behrend, and R. Kopelman. "Aspherical
magnetically modulated optical nanoprobes (MagMOONs),"
J. Appl. Phys. 93, 6698 (2003).
J.N. Anker and R. Kopelman. "Magnetically
modulated optical nanoprobes," Appl. Phys. Lett.
82, 1102 (2003).
2002
J.N. Anker, T. Horvath, and R. Kopelman. European Cells and
Materials 3, 34 (2002).
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