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bulletMOONs

MOONs are microscopic photonic probes that look like moons: their northern hemisphere appears bright and is colored with a fluorescent indicator dye whose color reports on the local chemical environment; the other side is darkened with an opaque metal layer. They rotate in response to thermal fluctuations in a fluid (Brownian MOONs) and to rotating magnetic fields (MagMOONs), blinking as they turn through the phases of the moon. The blinking stands out against the background like a lighthouse against city lights allowing sensitive chemical analysis from microscopic probes. The probes have applications for ultrasensitive ion and small molecule sensors within cells, and robust sensitive immunoassays in blood and other fluid samples.




A 4.4 micron fluorescent MagMOON

 

MOON References:

2005

B.H. McNaughton, V.A. Stoica, J.N.
Anker, R. Clarke, and R. Kopelman, Fabrication of uniform half-shell magnetic nanoparticles and microspheres with applications as magnetically modulated optical nanoprobes, Posted on arxiv.org (2005).

J.N. Anker, C.J. Behrend, and R. Kopelman., "Magnetically-modulated optical nanoprobes (MagMOONs) and systems," J. Magn. Magn. Mater.  293, 655 (2005).

C.J. Behrend, J.N. Anker,  B.H. McNaughton, R. Kopelman, Microrheology with modulated optical nanoprobes (MOONs), Journal of Magnetism and Magnetic Materials 293, 663-670 (2005).

B.H. McNaughton, J.N. Anker, R. Kopelman, Magnetic microdrill as a modulated fluorescent pH sensor, Journal of Magnetism and Magnetic Materials 293, 696-701 (2005).

T.G. Roberts, , J.N. Anker, R. Kopelman., " Magnetically modulated optical nanoprobes (MagMOONs) for detection and measurement of biologically important ions against the natural background fluorescence of intracellular environments," J. Magn. Magn. Mater.  293, 715 (2005).

2004
R.R.
Agayan, T. Horvath, B.H. McNaughton, J.N. Anker, R. Kopelman, Optical manipulation of metal-silica hybrid nanoparticles, Procedings of SPIE. 5514, 502-513 (2004).

C.J. Behrend, J.N. Anker, B.H. McNaughton, T.G. Roberts, M. Brasuel, M.A. Philbert, R. Kopelman, Metal-capped brownain and magnetically modulated optical nanoprobes (MOONs): micromechanics in chemical and biological microenvironments, Journal of Physical Chemistry B 108, 10408-10414 (2004).

 

C.J. Behrend, J.N. Anker, R. Kopelman, "Brownian modulated optical nanoprobes," Appl. Phys. Lett. 93, 6698-6700 (2004)

 

J.N. Anker, C.J. Behrend, B.H. McNaughton, T.G. Roberts, M. Brasuel, M.A. Philbert, Characterization and applications of modulated optical nanoprobes (MOONs) Mat. Res. Soc. Symp. Proc. 790, 4.4.1-12, (2004).  

2003
J.N. Anker, C. Behrend, and R. Kopelman. "Aspherical magnetically modulated optical nanoprobes (MagMOONs)," J. Appl. Phys.  93, 6698 (2003).

J.N. Anker and R. Kopelman. "Magnetically modulated optical nanoprobes," Appl. Phys. Lett.  82, 1102 (2003).

2002
J.N. Anker, T. Horvath, and R. Kopelman. European Cells and Materials 3, 34 (2002).

 

 

 

 


 

 

 

 

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