|Background & Current Research: My general research interests lie in molecular recognition, nanofabrication, and biosensors. Major efforts of my Ph.D. research program at State University of New York at Binghamton concentrated on biosensor development for the analysis of anticancer drugs (e.g., cisplatin and daunomycin), environmental pollutants (e.g., Microcystin-LR), and more. As a postdoctoral researcher in Dr. Raoul Kopelman group at University of Michigan, I am mainly involved in conducting a silicon-based nano-particle research called "Dynamic Nano-Platform" (DNP) funded by National Cancer Institute "Unconventional Innovations Program". DNPs are designed to be delivered into the blood stream and preferentially accumulate at the tumor site through specific molecular targeting. The same DNPs are used for photodynamic therapy (PDT), utilizing conserved, internalized photosensitizers for direct massive delivery of reactive oxygen species rather than release of PDT dyes
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Publications (of 14 total):
H. Xu, F. Yan, E. Monson, R. Kopelman, Room-temperature preparation and characterization of poly (ethylene glycol)- coated Stöber silica nanoparticles for biomedical applications. J. Biomed. Mater. Res. 2003, in press.
F. Yan, T. Loi, O. A. Sadik, Development of amperometric immunosensors for lectins using genetically engineered monoclonal antibodies. Biosens. Bioelectron. 2003, in press.
F. Yan, O.A. Sadik, Enzyme modulated cleavage of dsDNA for studying interfacial biomolecular interactions. J. Am. Chem. Soc. 2001, 123, 11335-11340.
F. Yan, O.A. Sadik, Enzyme modulated cleavage of dsDNA for supramolecular design of biosensors. Anal. Chem. 2001, 73, 5272-5280.
F. Yan, A. Erdem, B. Meric, K. Kerman, M. Ozsoz, O.A. Sadik, Electrochemical DNA biosensor for the detection of specific gene related to Microcystis species. Electrochem. Commun. 2001, 3, 224-228.
F. Yan, R. McNally, E.J. Kontanis, O.A. Sadik, Preliminary quantitative investigation of postmortem adipocere formation. J. Forensic Sci. 2001, 46(2), 185-190.
F. Yan, M. Ozsoz, O.A. Sadik, Electrochemical and conformational studies of Microcystin-LR. Anal. Chim. Acta, 2000, 409, 247-255.