|Background: I received my B.S. degree in chemistry from Beijing University of Chemical Technology in 1997, and then came directly to the University of Michigan and joined Dr. Kopelman’s group for my Ph.D study.
Current Research: As an analytical chemistry student, the main focus of my research has been the fabrication and characterization of sol-gel- and polyacrylamide-based optical nanosensors for intracellular measurements of biologically important species, such as molecular oxygen, and glucose. The current challenge in my research is to apply the polyacrylamide-based nanosensors for measurements of glucose changes in cultured human cell lines using fluorescence microscopy.
H. Xu, F. Yan, E. Monson, R. Kopelman (2003). Room-temperature preparation and characterization of poly (ethylene glycol)-coated Stöber silica nanoparticles for biomedical applications. Journal of Biomedical Materials Research. In press.
Xu H, Aylott JW, Kopelman R (2002). Fluorescent nano-PEBBLE sensors designed for intracellular glucose imaging. The Analyst 127: 1471-1477 2002
Brasuel M, Kopelman R, Aylott JW, Clark H, Xu H, Hoyer M, Miller TJ, Tjalkens R, Philbert MA (2002). Production, characteristics and applications of fluorescent PEBBLE nanosensors: Potassium, oxygen, calcium and pH imaging inside live cells. Sensors and Materials 14: 309-338.
Xu H, Aylott JW, Kopelman R, Miller TJ, Philbert MA (2001). A real-time ratiometric method for the determination of molecular oxygen inside living cells using sol-gel-based spherical optical nanosensors with applications to rat C6 glioma. Analytical Chemistry 73 : 4124-4133.
Xu H, Aylott J, Kopelman R (2000). Sol-gel pebble sensors for biochemical analysis inside living cells. Abstracts of Papers of the American Chemical Society 219: 97-ANYL Part 1