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Autonomous Nano-Devices for Biomedical Applications:

Single or schools of nanodevices serve as roaming nano-sensors or nano-activators, based on their local biochemical. biophysical or quantum physics interactions, and their remote photonic, magnetic or electric communication.

The 20 200 nm chemical and physical nanosensors have been designed, synthesized and used for non-perturbative imaging in live cells. This imaging tracks small molecules (oxygen, glucose, etc.), radicals (OH, superoxide, etc.), ions (calcium, potassium, etc.), as well as local physical parameters (electric, magnetic, mechanical, thermal). They have been instrumental in the elucidation of the roles of toxins, bacteria and metabolic processes in specific cells. Collaborators are Professors Roy Clarke (Applied Physics), Carol Fierke (Chemical Biology), Martin Philbert (Neurotoxicology) and Ann-Marie Sastry (Biomedical Engineering).

The 20 -100 nm nano-activators are bio-targeted modular nano-platforms for enhanced in-vivo imaging (optical, MRI, etc.) and diagnostics, as well as therapy (radiation, photodynamic, etc.). They have been used successfully in the detection, monitoring and therapy of brain cancer models in rats. They have also been shown to be non-toxic, bio-degradable and bio-eliminable, with controllable residence times and no evident side effects. Steps towards FDA approval have been taken. Collaborators are Professors Martin Philbert (SPH) and Al Rehemtulla, Brian Ross and Oren Sagher (Medical School).

Photonic Explorers for Biomedical use by Biologically Localized Embedding (PEBBLEs)

Cancer Detection and Therapy using PEBBLEs

Modulated Optical Nanoprobes (MOONs)

Optical Tweezers

More Research:

Reaction Kinetics & Dendrimers




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