Bio-Analytical NanoScale Chemistry & Materials

Nano-Scale Analysis
Fiber-Optic Roots
Enter PEBBLEs
Oxygen PEBBLE Example
• Ratiometric Device
• Response & Interference
• Quantitative Imaging
Delivery Methods
• Gene Gun
• Liposomal
PEBBLE Production
• Wet Chemistry Method
• PEBBLE Sizes
• Surface Modification
Decyl Methacrylate Example
• Fabrication
• Response
Nitric Oxide Sensing
• cGMP Cycle
• Lifetime Detection
Analytic Summary
PEBBLE sensor
Summary of PEBBLE accomplishments:
  • 20 nm radius Optochemical Biosensors (1 ppb of cell vol.)
  • Non-Invasive Chem Lab inside Live Cell
  • Cell Viability 97%
  • Response Time < 1 ms.
  • H+, Ca2+, K+, Na+, Mg2+, Cl–, NO2–, O2, NO, Glucose…

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Page Updated Tuesday, November 06, 2001
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University of Michigan