Lahann Lab

Department of Chemical Engineering
University of Michigan

Institute of Functional Interfaces
Karlsruhe Institute of Technology




Journal Articles


P. Podsiadlo, A.K. Kaushik, E.M. Arruda, A.M. Waas, B.S. Shim, J. Xu, H. Nandivada, B.G. Pumplin, J. Lahann, A. Ramamoorthy, N.A. Kotov, "Ultrastrong and stiff layered polymer nanocomposites", Science (2007) 318(5847), 80-83.

P. Katira, A. Agarwal, T. Fischer, H.Y. Chen, X. Jiang, J. Lahann, H. Hess, "Quantifying the performance of protein-resisting surfaces at ultra-low protein coverages using kinesin motor proteins as probes", Advanced Materials (2007) 19, 3171-3176 (invited paper).

2007LangmuirDavid D.K. Peng, J. Lahann, "Chemical, Electrochemical, and Structural Stability of Low-Density Self-Assembled Monolayers", Langmuir (2007) 23, 10184-10189.

P. Podsiadlo, L. Sui, Y. Elkasabi, P. Burgardt, J. Lee, A. Miryala, W. Kusumaatmaja, M.R. Carman, M. Shtein, J. Kieffer, J. Lahann, N. Kotov, "Layer-by-Layer Assembled Films of Cellulose Nanowires with Antireflective Properties", Langmuir (2007), 23, 15, 7901-7906.

S. Thevenet, H-Y. Chen, J. Lahann, F. Stellaci, "A generic approach towards nanostructured surfaces based on supramolecular nanostamping on reactive polymer coatings", Advanced Materials (2007) 19(24), 4333-4337.

Various surfaces can successfully be coated with reactive polymer coatings and then patterned with DNA features using supramocular nanostamping (SuNS). Surfaces as different as silicon, quartz, polystyrene, PMMA and PDMS have been patterned using the same protocol. In addition to the previously demonstrated high resolution and high information transfer of SuNS this approach makes it a substrate-independent method.

K-H. Roh, M. Yoshida, J. Lahann, "Compartmentalized, multiphasic nanocolloids with potential applications in drug delivery and biomedical imaging", Materialwissenschaft und werkstofftechnik (2007) 38(12), 1008-1011.

Nanoparticles are excellent candidates for drug delivery or biomedical imaging, because they often exhibit superb tuneability of critical properties, such as size, surface characteristics, degradation rate, and therefore drug release rates. We have recently developed a route towards fabrication of sub-micron particles that relies on electrohydrodynamic co-jetting. In this process, fluid manipulation in an electrical field is used to fabricate large quantities of multi-compartment particles, where individual compartments can be independently loaded with different drugs or selectively surface-modified. In this contribution, aspects of multifunctional particles for biomedical applications are reviewed and a specific focus is given to recent progress with compartmentalized, multiphasic nanocolloids in our laboratory.

2007-Advanced Material

H-Y. Chen, J. Lahann, "Vapor-assisted micropatterning in replica structures: A solventless approach towards topologically and chemically designable surfaces", Advanced Materials (2007) 19(22), 3801-3808.

Vapor-assisted micropatterning in replica structures (VAMPIR) provides a simple method for fabricating both, chemically and topologically designable surfaces based on chemical vapor deposition polymerization. The images show surface microstructures containing fluorescence-labeled proteins or quantum dots.

H. Nandivada, X. Jiang, J. Lahann, "Click Chemistry: Versatility and control in the hands of materials scientists", Advanced Materials (2007) 19, 2197-2208.


H.-Y. Chen, J.-M. Rouillard, E. Gulari, J. Lahann, "Colloids with High-Definition Surface Structures", PNAS (2007) 104 (27), 11173-11178.

A highthroughput projection lithography technique was applied on micro-spheres which were modified previously by photodefinable CVD polymer. This method can yield surface-structured colloidal particles at a rate of 107 to 108 particles per operator per day. Equipped with spatially defined binding pockets, microstructured colloids can engage in programmable interactions, which can lead to directed self-assembly. The ability to create a wide range of colloids with both simple and complex surface patterns may contribute to the genesis of previously unknown colloidal structures and may have important technological implications in a range of different applications, including photonic and phononic materials or chemical sensors.

M. Yoshida, K.H. Roh, J. Lahann, "Short-term biocompatibility of biphasic nanocolloids with potential use as anisotropic imaging probes", Biomaterials (2007) 28, 15, 2446-2456.


K.H. Roh, M. Yoshida, J. Lahann, "Water-stable Biphasic Nanocolloids with Potential Use as Anisotropic Imaging Probes", Langmuir (2007) 23, 10, 5683-5688.

Artistic rendering of water- stable biphasic nanocolloids, which are prepared by electrified co-jetting of two jetting solutions through side-by-side capillaries and subsequent thermal imidization reaction. Two aqueous polymer solutions containing different biomolecules were employed as jetting solutions. Originally, water-soluble particles become water-insoluble by thermal imidization reaction, and the colloid suspension showed stability over multiple weeks in an aqueous environment.

D.K. Peng. S.T. Yu, D.J. Alberts, J. Lahann, "Switching the Electrochemical Impedance of Low-Density Self-Assembled Monolayers", Langmuir (2007) 23, 1, 297-304.


L. Villa-Diaz, H. Nandivada, J. Ding, S. O'Shea, J. Lahann, G. Smith, "Culture and passage of human embryonic stem cells on an artificial synthetic matrix composed of polyMEDSAH hydrogel", Biology of Reproduction (2007), 186-186.

K.-H. Roh, J. Lahann, "Anisotropic encapsulation of supermagentic nanocrystals in polymeric biphasic nanocolloids", Polymer Preprints (2007) 48, 209-210