Lahann Lab

Department of Chemical Engineering
University of Michigan

Institute of Functional Interfaces
Karlsruhe Institute of Technology




Journal Articles

Aftin's Cover



S. Rahmani, C. H. Villa, A. F. Dishman, M. E. Grabowski, D. C. Pan, H. Durmaz, A. C. Misra, L. Colon-Melendez, M. J. Solomon, V. R. Muzykantov and J. Lahann, "Long-circulating Janus nanoparticles made by electrohydrodynamic co-jetting for systemic drug delivery applications", J Drug Target, (2015).

A. M. Ross and J. Lahann, "Current Trends and Challenges in Biointerfaces Science and Engineering", Annu Rev Chem Biomol Eng, (2015).

A. C. Misra, K. E. Luker, H. Durmaz, G. D. Luker and J. Lahann, "CXCR4-Targeted Nanocarriers for Triple Negative Breast Cancers", Biomacromolecules, (2015).

E. Sokolovskaya, S. Rahmani, A. C. Misra, S. Brase and J. Lahann, "Dual Stimuli-Responsive Microparticles", ACS Applied Materials & Interfaces, (2015).

Jaewon Yoon, Tom W. Eyster, Asish C. Misra, Joerg Lahann, “Cardiomyocyte-Driven Actuation in Biohybrid Microcylinders” Advanced Materials, (2015)


A. Ross, H. Durmaz, K. Cheng, X. P. Deng, Y. W. Liu, J. Oh, Z. Chen and J. Lahann, "Selective and Reversible Binding of Thiol-Functionalized Biomolecules on Polymers Prepared via Chemical Vapor Deposition Polymerization", Langmuir, (2015).

F. B. L. Gall, C. Friedmann, L. Heinke, H. Arslan, C. Azucena, A. Welle, A. M. Ross, C. Woll and J. Lahann, "Free-Standing Nanomembranes Based on Selective CVD Deposition of Functional Poly-p-xylylenes", ACS Nano, (2015).

S. Schmitt, M. Silvestre, M. Tsotsalas, A. L. Winkler, A. Shahnas, S. Grosjean, F. Laye, H. Gliemann, J. Lahann, S. Brase, M. Franzreb and C. Woll, "Hierarchically Functionalized Magnetic Core/Multishell Particles and Their Postsynthetic Conversion to Polymer Capsules", ACS Nano, (2015).

Y. Liang, X. P. Deng, J. J. Senkevich, H. Ding and J. Lahann, "Thermal and environmental stability of poly(4-ethynyl-p-xylylene-co-p-xylylene) thin films", Chinese Chemical Letters, (2015).


X. Qian, L. G. Villa-Diaz, R. Kumar, J. Lahann, P. H. Krebsbach, "Enhancement of the propagation of human embryonic stem cells by modifications in the gel architecture of PMEDSAH polymer coatings", Biomaterials, (2014).

V. Mugnaini, M. Tsotsalas, F. Bebensee, S. Grosjean, A. Shahnas, S. Bräse, J. Lahann, M. Buck, C. Wöll, "Electrochemical investigation of covalently post-synthetic modified SURGEL coatings", ChemComm, (2014).

S. M. S. Schonwalder, F. Bally, L. Heinke, C. Azucena, O. D. Bulut, S. Heibler, F. Kirschhofer, T. P. Gebauer, A. T. Neffe, A. Lendlein, G. Brenner-WeiB, J. Lahann, A. Welle, J. Overhage, C. Wöll, "Interaction of Human Plasma Proteins with Thin Gelatin-Based Hydrogel Films: A QCM-D and ToF-SIMS Study", Biomacromolecules, (2014).

Y. Elkasabi, A. F. Ross, J. Oh, M. P. Hoepfner, H. S. Fogler, J. Lahann, P. H. Krebsbach, "Design Strategies for Reduced-scale Surface Composition Gradients via CVD Copolymerization", Chemical Vapor Deposition, (2014) 20, 23-31.

J. M. Hankett, A. Welle, J. Lahann, and Z. Chen, "Evaluating UV/H2O2 Exposure as a DEHP Degradation Treatment for Plasticized PVC", Journal of Applied Polymer Science, (2014).

S. Rahmani and J. Lahann, "Recent Progress with Multicompartmental Nanoparticles", MRS Bulletin, (2014) 39, 251-257.

T.-H. Park, K. J. Lee, S. Hwang, J. Yoon, C. Wöll, J. Lahann, "Spatioselective Growth of Metal-Organic Framework Nanocrystals on Compositionally Anisotropic Polymer Particles", Adv. Mat., (2014).

S. Rahmani, S. Saha, H. Durmaz, A. Donini, A. C Misra, J. Yoon, J. Lahann, "Chemically Orthogonal Three-Patch Microparticles", Angew. Chem. Int. Ed., (2014) 53, 2332-2338.

E. Sokolovskaya, L. Barner, S. Bräse, J. Lahann, "Synthesis and On-Deman Gelation of Multifunctional Poly(ethylene glycol)-Based Polymers", Macromol. Rapid Comm., (2014).

A. M. Greiner, M. Jäckel, A. C. Scheiwe, D. R. Stamow, T. J. Autenrieth, J. Lahann, C. M. Franz, M. Bastmeyer, "Multifunctional polymer scaffolds with adjustable pore size and chemoattractant gradients for studying cell matrix invasion", Biomaterials, (2014) 35 (2), 611–619.

JACS 2014

M. Tsotsalas, J. Liu, B. Tettmann, S. Grosjean, A. Shahnas, Z. Wang, C. Azucena, M. Addicoat, T. Heine, J. Lahann, J. Overhage, S. Bräse, H. Gliemann, C. Wöll, "Fabrication of Highly Uniform Gel Coatings by the Conversion of Surface-Anchored Metal-Organic Frameworks", Journal of the American Chemical Society, (2014) 136, 8-11.

cvd 2014

X. Deng, J. Lahann, "Orthogonal surface functionalization through bioactive vapor-based polymer coatings", Journal of Applied Polymer Science, (2014).


J. Yoon, A. K. Kota, S. Bhaskar, A. Tuteja, J. Lahann, "Amphiphilic Colloidal Surfactants Based on Electrohydrodynamic Co-Jetting", ACS Applied Material & Interfaces, (2013) 5 (21), 11281–11287.

S. Rahmani, T.-H. Park, A. F. Dishman, and J. Lahann, "Multimodal delivery of irinotecan from microparticles with two distinct compartments", Journal of Controlled Release, (2013) 172 (1), 239–241.

Ekaterina Sokolovskaya, Jaewon Yoon, Asish C Misra, Stefan Bräse, and Joerg Lahann, "Controlled Microstructuring of Janus Particles Based on a Multifunctional Poly (ethylene glycol)", Macromolecular Rapid Communications, (2013) 34 (19), 1554–1559.

Björn Waterkotte, Florence Bally, Pavel M. Nikolov, Ansgar Waldbaur, Bastian E. Rapp, Roman Truckenmüller, Joerg Lahann, Katja Schmitz, and Stefan Giselbrecht, "Biofunctional Micropatterning of Thermoformed 3D Stubstrates", Advanced Functional Materials, (2013) 24 (4), 442–450.


Florence Bally, Kenneth Cheng, Himabindu Nandivada, Xiaopei Deng, Aftin Ross, Agusti Panades, and Joerg Lahann, "Co-Immobilization of Biomolecules on Ultrathin Reactive Chemical Vapor Deposition Coatings Using Multiple Click Chemistry Strategies", ACS Applied Materials & Interfaces, (2013) 5 (19), 9262–9268.

Weipeng Lv, Kyung Jin Lee, Sangyeul Hwang, Tae-Hong Park, Fengbao Zhang, and Joerg Lahann, "A Facile Route Towards Inorganic Particles with Two Distinct Compartments Based on Electro-Hydrodynamic Co-Jetting", Particle & Particle Systems Characterization, (2013) 30 (11), 936–939.

Kyung Jin Lee, Tae-Hong Park, Sangyeul Hwang, Jaewon Yoon, and Joerg Lahann, "Janus-Core and Shell Microfibers", Langmuir, (2013) 29 (20), 6181–6186.

Tae-Hong Park, Thomas W. Eyster, Joshua M. Lumley, Sangyeul Hwang, Kyung Jin Lee, Asish Misra, Sahar Rahmani, and Joerg Lahann, "Photoswitchable particles for on-demand degradation and triggered release", Small, (2013) 9 (18), 3051–3057.

A. M. Ross, J. Lahann, "Surface engineering the cellular microenvironment via patterning and gradients", Journal of Polymer Science Part B: Polymer Physics, (2013), 51 (10), 775-794.

L. G. Villa-Diaz, A. M. Ross, J. Lahann, P. H. Krebsbach, "The Evolution of Human Pluripotent Stem Cell Culture: From Feeder Cells to Synthetic Coatings", Stem Cells, (2013), 31 (1), 1-7

J. Lahann, "Stimuli-responsiveness based on anisotropic polymer architectures", Abstracts of Papers of the American Chemical Society (2013) 245, 576-PMSE.



T. D. Yoshida Kozai, N. B. Langhals, P. R. Patel, X. Deng, H. Zhang, K. L. Smith, J. Lahann, N. A. Kotov, D. R. Kipke, "Ultrasmall Implantable Composite Microelectrodes with Bioactive Surfaces for Chronic Neural Interfaces", Nature Materials (2012) 11, 1065-1073.

PNAS 2012

K. J. Lee*, J. Yoon*, S. Rahmani, S. Hwang, S. Bhaskar, S. Mitragotri, J. Lahann, "Spontaneous Shape Reconfiguration in Multicompartmental Microcylinders", PNAS (2012) 109 (40), 16057-16062.

X. Deng, J. Lahann, "A Generic Strategy for Co-Presentation of Heparin-Binding Growth Factors Based on CVD Polymerization", Macromolecular Rapid Communications (2012) 33 (17),  1459–1465.

W. Lv, K. J. Lee, J. Li, T. H. Park, S. Hwang, A. J. Hart, F. Zhang, J. Lahann, "Anisotropic Janus Catalysts for Spatially Controlled Chemical Reactions", Small (2012) 8 (20), 3116–3122.

J. Lahann, S. Mitragotri, "Materials for Drug Delivery: Innovative Solutions to Address Complex Biological Hurdles", Advanced Materials (2012) 24 (28), 3717-3723, (Editorial).

A. Agarwal, E. Luria, X. Deng, J. Lahann, H. Hess, "Landing Rate Measurements to Detect Fibrinogen Adsorption to Non-fouling Surfaces", Cellular and Molecular Engineering (2012) 5(3), 320-326.

MRC 2012 Sangyeul

S. Hwang, J. Lahann, "Differentially Degradable Janus Particles for Controlled Release Applications", Macromolecular Rapid Communications (2012), 33(14), 1178-83.

A. C Misra, S. Bhaskar, N. Clay, J. Lahann, "Multicompartmental Particles for Combined Imaging and siRNA Delivery", Advanced Materials (2012) 24, 3850–3856.

A. M. Ross, H. Nandivada, A. L. Ryan, J. Lahann, "Synthetic Substrates for Long-Term Stem Cell Culture", Polymer (2012) 53 (13) 2533–2539.

L. G. Villa-Diaz, S. E. Brown, Y. Liu, A. M. Ross, J. Lahann, J. M. Parent, P. H. Krebsbach, "Derivation of Mesenchymal Stem Cells from Human Induced Pluripotent Stem Cells Cultured on Synthetic Substrates", Stem Cells (2012) 30(6), 1174-81.

X. Deng*, T. W. Eyster*, Y. Elkasabi, J. Lahann, "Bio-Orthogonal Polymer Coatings for Co-Presentation of Biomolecules", Macromolecular Rapid Communications (2012) 33, 640-645.

D. Frank, M. Nieger, C. Friedmann, J. Lahann, S. Brase, "Functional Paracyclophanes: Synthesis of [2.2] Paracyclophanemethyldithiocarbonates Using Thione-Thiol Rearrangement of S, O-Dithiocarbonates (Benzyl Schonberg Rearrangement) at Mild Conditions", Israel Journal of Chemistry, (2012) 52(1-2), 143-148.

S. Saha, D. Copic, S. Bhaskar, N. Clay, A. Donini, A. J. Hart, J. Lahann, "Chemically Controlled Bending of Compositionally Anisotropic Microcylinders", Angewandte Chemie International Edition (2012) 51 (3), 660-665.

A.M. Ross, Z. Jiang, M. Bastmeyer, J. Lahann, "Physical Aspects of Cell Culture Substrates: Topography, Roughness, and Elasticity", Small (2012) 8(3), 336-355.



Z. Qu, S. Muthukrishnan, M. K. Urlam, C. A. Haller, S. W. Jordan, V. A. Kumar, U. M. Marzec, Y. Elkasabi, J. Lahann, S. R. Hanson, E. L. Chaikof, "A Biologically Active Surface Enzyme Assembly that Attenuates Thrombus Formation", Advanced Functional Materials (2011) 21, 4736-4743.

X. Deng, C. Friedmann, J. Lahann, "Bio-Orthogonal "Double-Click" Chemistry Based on Multifunctional Coatings", Angewandte Chemie International Edition (2011) 50, 6522-6526.

H. Nandivada, L. G. Villa-Diaz, K. S. O'Shea, G. D. Smith, P. H. Krebsbach, J. Lahann, "Fabrication of Synthetic Polymer Coatings and Their Use in Feeder-Free Culture of Human Embryonic Stem Cells", Nature Protocols (2011) 6, 1037-1043.

Anisotropic Articles 2011

J. Yoon*, K. J. Lee*, J. Lahann, "Multifunctional Polymer Particles with Distinct Compartments", Journal of Materials Chemistry (2011) 21(24), 8502-8510 (Feature Article, Invited).

Anisotropic Articles 2011

J. Lahann, "Recent Progress in Nanobiotechnology: Compartmentalized Micro- and Nanoparticles via Electrohydrodynamic Co-jetting", Small (2011) 7(9), 1149-1156.

Anisotropic Articles 2011

K. J. Lee*, J. Yoon*, J. Lahann, "Recent advances with anisotropic particles", Current Opinion in Colloid & Interface Science (2011) 16, 195-202.

Photoreactions2011 K. J. Lee, S. Hwang, J. Yoon, S. Bhaskar, T.-H. Park, J. Lahann, "Compartmentalized Photoreactions within Compositionally Aniostropic Janus Microstructures", Macromolecular Rapid Communications, (2011) 32(5), 431-437 (Cover Article).

MicropatterningWithParticles2011 S. Bhaskar, C.T. Gibson, M. Yoshida, H. Nandivada, X. Deng, N.H. Voelcker, J. Lahann, "Engineering Characterization and Directional Self-Assembly of Anisotropically Modified Nanocolloids", Small (2011) 7(6), 812-819.

Designable Biointerfaces2011 H.Y. Chen, J. Lahann, "Designable Biointerfaces Using Vapor-Based Reactive Polymers", Langmuir (2011) 27(1), 34–48 (Feature Article, Cover Article).

Biomaterials CVD Transduction Y. Elkasabi, J. Lahann, P. Krebsbach, "Cellular Transduction Gradients via Vapor-Deposited Polymer Coatings", Biomaterials (2011) 32 (7), 1809-1815.

CVD Elipsometry2011 A. Ross, D. Zhang, X. Deng, S.L. Chang, J. Lahann "CVD-based Binding Substrates for Spatially Rresolved Analysis of Protein Binding by Imaging Ellipsometry", Analytical Chemistry (2011) 83(3), 874-880.


H.Y. Chen, M. Hirtz, X. Deng, T. Laue, H. Fuchs, J. Lahann, "Substrate-Independent Dip-Pen Nanolithography Based on Reactive Coatings", JACS (2010) 132(51), 18023–18025.

S. Hwang, K.-H. Roh, D. W. Lim, G. Wang, C. Uher and J. Lahann, "Anisotropic hybrid particles based on electrohydrodynamic co-jetting of nanoparticle suspensions", Phys. Chem. Chem. Phys. (2010)12, 11894-11899.


  H.Y. Chen, J. Lahann, "Surface Modification Strategies for Microfluidics based on Reactive Coatings", Bioanalysis (2010), 2, 10, 1717–1728.


Y. Zhang, X. Deng, E.L. Scheller, J. Lahann, R.T. Franceschi, P.H. Krebsbach, "The effect of Runx2 immobilization on poly(epsilon-caprolactone) on osteoblast differentiation of bone marrow stromal cells in vitro", Biomaterials (2010) 32(7), 1809-1816.


S. Tawfick, X. Deng, A.J. Hart, J. Lahann, "Nanocomposite Microstructures with Tunable Mechanical and Chemical Properties", Phys. Chem. Chem. Phys.  (2010) 12, 11894-11899 (invited paper).


L. G. Villa-Diaz*, H. Nandivada*, J. Ding, N. C. Nogueira-de-Souza, P. H. Krebsbach, K. Sue O'Shea, J. Lahann and G. D. Smith "Synthetic polymer coatings for long-term growth of human embryonic stem cells", Nature Biotechnology (2010) 28(6), 581-583. [*co-first-authors]

H. Nandivada, A. M. Ross, J. Lahann, "Stimuli responsive monolayers for biotechnology", Progress in Polymer Science (2010) 35(1-2), 141-154.

D. W. Lim, S. Hwang, O. Uzun, F. Stellacci, J. Lahann, "Compartmentalization of Gold Nanocrystals in Polymer Microparticles Using Electrohydrodynamic Co-jetting", Macromolecular Rapid Communications (2010) 31(2), 176-182.

A. Kazemi, J. Lahann, M. Madani, N. S. Sanjani, A. H. Kaviar, "Preparation of Core-Shell and Hollow Fibers Using Layer by Layer (LbL) Self-Assembly of Polyelectrolytes on Electrospun Submicrometer-Scale Silica Fibers", Polymer Science Series B (2010) 52(9-10), 571-574.

S. Bhaskar, K. M. Pollock, M. Yoshida, J. Lahann, "Towards Designer Microparticles: Simultaneous Control of Anisotropy, Shape, and Size", Small (2010) 6(3), 404-411.

R.G. Larson, M. Alumnà López, D.W. Lim, J. Lahann, "Complex Protein Patterns in Drying Droplets", MRS Proceedings (2010) (online publication).

J. Lahann, "Multifunctional Nano- and Microparticles – quo vadis?", Macromolecular Rapid Communications (2010) 31, 105-107.

Y. Elkasabi, J. Lahann, "Progress Report on Microstructured Surfaces Based on Chemical Vapor Deposition", in Biological Microarrays: Methods & Protocols, Methods in Molecular Biology, vol. 671, ed. A. Khademhosseini, Springer Science+Business Media, (2010).


N. Doshi, A.S. Zahr, S. Bhaskar, J. Lahann, S. Mitragotri, "Red Blood Cell-Mimetic Particles: Bridging the Gap between Synthetic and Biological Materials", Proceedings of the National Academy of Sciences (2009) 106, 21495–21499.


W.-W. Hu, Y. Elkasabi, H.-Y. Chen, Y. Zhang, J. Lahann, S.J. Hollister, P.H. Krebsbach, "The use of reactive polymer coatings to facilitate gene delivery from poly(epsilon-caprolactone) scaffolds", Biomaterials (2009) 30, 5785-5792.


J.P. Seymour, Y. Elkasabi, H.-Y. Chen, J. Lahann, D.R. Kipke, "The insulation performance of reactive parylene films in implantable electronic devices", Biomaterials (2009) 30, 5785-5792.


M. Yoshida, K-H. Roh, S. Mandal, S. Bhaskar, D. W. Lim, H. Nandivada, X. Deng, J. Lahann, "Structurally Controlled Bio-hybrid Materials Based on Unidirectional Association of Anisotropic Microparticles with Human Endothelial Cells", Advanced Materials (2009) 21(48), 4920-4925.

S. Mandal, S. Bhaskar, J. Lahann, "Micropatterned Fiber Scaffolds for Spatially-Controlled Cell Adhesion", Macromolecular Rapid Communications (2009) 131(19), 6650-6651.

Y. Elkasabi, H. Nandivada, H-Y Chen, S. Bhaskar, J. D'Arcy, L. Bondarenko, J. Lahann, "Partially Fluorinated Poly-p-xylylenes Synthesized by CVD Polymerization", Chemical Vapor deposition (2009) 15(4-6), 142-149.

A. Sun and J. Lahann, "Dynamically Switchable Biointerfaces" Soft Matter (2009) 5(8), 1555-1561.

S. Bhaskar, J. Hitt, S-W. L. Chang, J. Lahann, "Multicompartmental Microcylinders" Angew Chemie Int Ed 48(25), 4589-4593.

S. Bhaskar, J. Lahann, "Microstructured Materials based on Multicompartmental Fibers", JACS 131(19), 6650-6651.

S. Mitragotri and J. Lahann, "Physical approaches to biomaterial design", Nature Materials (2009) 8, 15-23.

Y. Elkasabi, J. Lahann, "Vapor-based polymer gradients", Macromolecular Rapid Communications (2009) 30, 1, 57-63.


D.N. Hohne, H.-Y. Chen, J. Lahann, M.J. Solomon, "Near-Surface structure of lithographic in-fountain solution emulsions on model substrates", Colloids and Surfaces A 2008, 326, 138-146.

A. Kazemi, J. Lahann, "Environmentallly responsive core/shell particles via electrohydrodynamic co-jetting of fully miscible polymer solutions", Small (2008) 4(10), 1756-1762.

S. Bhaskar, K-H. Roh, X.W. Jiang, G.L. Baker, J. Lahann, "Spatioselective modification of bicompartmental polymer particles and fibers via Huisgen 1,3-dipolar cycloaddition", Macromolecular rapid communications (2008) 29(20), 1655-1660.

D.K. Peng, A.A. Ahmadi, J. Lahann, "A synthetic surface that undergoes spatiotemporal remodeling", Nano Letters (2008) 8(10), 3336-3340.

H.Y. Chen, J.H Lai, X.W. Jiang, J. Lahann, "Substrate-selective chemical vapor deposition of reactive polymer coatings", Advanced Materials (2008) 20(18), 3474.

Metal-mediated inhibition of CVD polymerization of functionalized [2.2]paracyclophane with a wide range of functional groups is investigated and selective deposition is established for poly(4-vinyl-p-xylylene-co-p-xylylene).

Y. Elkasabi, M. Yoshida, H. Nandivada, H-Y. Chen, J. Lahann, "Towards multipotent coatings: Chemical vapor deposition and biofunctionalization of carbonyl-substituted copolymers", Macromolecular rapid communications (2008) 29(11), 855-870.

We report the development of multifunctional polymer coatings made by chemical vapor deposition (CVD) copolymerization.

M. Yoshida, J. Lahann, "Smart Nanomaterials", ACS Nano (2008) 2(6), 1101-1107. [Perspective]

“Smart” materials are materials that undergo dynamic and reversible changes in specific properties in response to certain environmental stimuli. In this perspective, challenges in the field of "smart" materials are highlighted.

J. Lahann, "Environmental nanotechnology - Nanomaterials clean up", Nature Nanotechnology (2008) 3(6), 320-321.


Hsien-Yeh Chen, Arthur McClelland, Zhan Chen, Joerg Lahann, "Solventless Adhesive Bonding Using Reactive Polymer Coatings", Analytical Chemistry (2008) 80(11), 4119-4124.

A novel solventless adhesive bonding (SAB) process is reported, which is applicable to a wide range of materials including, but not limited to, poly(dimethylsiloxane) (PDMS). The bonding is achieved through reactions between two complementary polymer coatings, poly(4-aminomethyl- p-xylylene- co- p-xylylene) and poly(4-formyl- p-xylylene- co- p-xylylene), which are prepared by chemical vapor deposition (CVD) polymerization of the corresponding [2.2]paracyclophanes and can be deposited on complementary microfluidic units to be bonded. These CVD-based polymer films form well-adherent coatings on a range of different substrate materials including polymers, glass, silicon, metals, or paper and can be stored for extended periods prior to bonding without losing their bonding capability.

X. Jiang, H.-Y. Chen, G. Galvan, M. Yoshida, J. Lahann, "Vapor-based initiator coatings for atom transfer radical polymerization", Advanced Functional Materials (2008) 18(1), 27-35.

Chemical vapor deposition of [2.2]paracyclophane-4-methyl 2-bromoisobutyrate was prepared on a wide range of materials as initiator coating. Surface initiated atom transfer radical polymerization of a oligo(ethylene glycol) methyl ether methacrylate was demonstrated on these surfaces as model example for the regulations of protein adsorption and cell adhesion.

W.L. Huang, Z. Ren, Y.W. Lin, H.Y. Chen, J. Lahann, "C.T.C. Nguyen, MEMS 2008: 21st IEEE International Conference on Micro-electro-mechanical Systems", Technical Digest (2008) 10-13.

H. Wang, S. Bhaskar, J. Lahann, Y.G. Lee, "Optical Trapping of Janus Particles", Proc. of SPIE (2008) 7038, 703813-1 – 703813-8.

H. Nandivada, X. Jiang, A. Panades, A. Bourke, M. Yoshida, H.Y. Chen, J. Lahann, "Bioimmobilization using Huisgen [1.3]-dipolar cycloaddition on vapor-based coatings", Polymer Preprints (2008).

H.Y. Chen, X. Jiang, M. Yoshida, J. Lahann, "Spatially controlled engineering of biointerfaces via functionalized poly-p-xylylenes", Polymer Preprints (2008).

Y. Elkasabi, M. Yoshida, J. Lahann, "Multifunctional biomedical coatings via chemical vapor deposition co-polymerization of [2.2]paracyclophanes", Polymer Preprints (2008).


P. Podsiadlo, A.K. Kaushik, E.M. Arruda, A.M. Waas, B.S. Shim, J. Xu, H. Nandivada, B.G. Pumplin, J. Lahann, A. Ramamoorthy, N.A. Kotov, "Ultrastrong and stiff layered polymer nanocomposites", Science (2007) 318(5847), 80-83.

P. Katira, A. Agarwal, T. Fischer, H.Y. Chen, X. Jiang, J. Lahann, H. Hess, "Quantifying the performance of protein-resisting surfaces at ultra-low protein coverages using kinesin motor proteins as probes", Advanced Materials (2007) 19, 3171-3176 (invited paper).

2007LangmuirDavid D.K. Peng, J. Lahann, "Chemical, Electrochemical, and Structural Stability of Low-Density Self-Assembled Monolayers", Langmuir (2007) 23, 10184-10189.

P. Podsiadlo, L. Sui, Y. Elkasabi, P. Burgardt, J. Lee, A. Miryala, W. Kusumaatmaja, M.R. Carman, M. Shtein, J. Kieffer, J. Lahann, N. Kotov, "Layer-by-Layer Assembled Films of Cellulose Nanowires with Antireflective Properties", Langmuir (2007), 23, 15, 7901-7906.

S. Thevenet, H-Y. Chen, J. Lahann, F. Stellaci, "A generic approach towards nanostructured surfaces based on supramolecular nanostamping on reactive polymer coatings", Advanced Materials (2007) 19(24), 4333-4337.

Various surfaces can successfully be coated with reactive polymer coatings and then patterned with DNA features using supramocular nanostamping (SuNS). Surfaces as different as silicon, quartz, polystyrene, PMMA and PDMS have been patterned using the same protocol. In addition to the previously demonstrated high resolution and high information transfer of SuNS this approach makes it a substrate-independent method.

K-H. Roh, M. Yoshida, J. Lahann, "Compartmentalized, multiphasic nanocolloids with potential applications in drug delivery and biomedical imaging", Materialwissenschaft und werkstofftechnik (2007) 38(12), 1008-1011.

Nanoparticles are excellent candidates for drug delivery or biomedical imaging, because they often exhibit superb tuneability of critical properties, such as size, surface characteristics, degradation rate, and therefore drug release rates. We have recently developed a route towards fabrication of sub-micron particles that relies on electrohydrodynamic co-jetting. In this process, fluid manipulation in an electrical field is used to fabricate large quantities of multi-compartment particles, where individual compartments can be independently loaded with different drugs or selectively surface-modified. In this contribution, aspects of multifunctional particles for biomedical applications are reviewed and a specific focus is given to recent progress with compartmentalized, multiphasic nanocolloids in our laboratory.

2007-Advanced Material

H-Y. Chen, J. Lahann, "Vapor-assisted micropatterning in replica structures: A solventless approach towards topologically and chemically designable surfaces", Advanced Materials (2007) 19(22), 3801-3808.

Vapor-assisted micropatterning in replica structures (VAMPIR) provides a simple method for fabricating both, chemically and topologically designable surfaces based on chemical vapor deposition polymerization. The images show surface microstructures containing fluorescence-labeled proteins or quantum dots.

H. Nandivada, X. Jiang, J. Lahann, "Click Chemistry: Versatility and control in the hands of materials scientists", Advanced Materials (2007) 19, 2197-2208.


H.-Y. Chen, J.-M. Rouillard, E. Gulari, J. Lahann, "Colloids with High-Definition Surface Structures", PNAS (2007) 104 (27), 11173-11178.

A highthroughput projection lithography technique was applied on micro-spheres which were modified previously by photodefinable CVD polymer. This method can yield surface-structured colloidal particles at a rate of 107 to 108 particles per operator per day. Equipped with spatially defined binding pockets, microstructured colloids can engage in programmable interactions, which can lead to directed self-assembly. The ability to create a wide range of colloids with both simple and complex surface patterns may contribute to the genesis of previously unknown colloidal structures and may have important technological implications in a range of different applications, including photonic and phononic materials or chemical sensors.

M. Yoshida, K.H. Roh, J. Lahann, "Short-term biocompatibility of biphasic nanocolloids with potential use as anisotropic imaging probes", Biomaterials (2007) 28, 15, 2446-2456.


K.H. Roh, M. Yoshida, J. Lahann, "Water-stable Biphasic Nanocolloids with Potential Use as Anisotropic Imaging Probes", Langmuir (2007) 23, 10, 5683-5688.

Artistic rendering of water- stable biphasic nanocolloids, which are prepared by electrified co-jetting of two jetting solutions through side-by-side capillaries and subsequent thermal imidization reaction. Two aqueous polymer solutions containing different biomolecules were employed as jetting solutions. Originally, water-soluble particles become water-insoluble by thermal imidization reaction, and the colloid suspension showed stability over multiple weeks in an aqueous environment.

D.K. Peng. S.T. Yu, D.J. Alberts, J. Lahann, "Switching the Electrochemical Impedance of Low-Density Self-Assembled Monolayers", Langmuir (2007) 23, 1, 297-304.


L. Villa-Diaz, H. Nandivada, J. Ding, S. O'Shea, J. Lahann, G. Smith, "Culture and passage of human embryonic stem cells on an artificial synthetic matrix composed of polyMEDSAH hydrogel", Biology of Reproduction (2007), 186-186.

K.-H. Roh, J. Lahann, "Anisotropic encapsulation of supermagentic nanocrystals in polymeric biphasic nanocolloids", Polymer Preprints (2007) 48, 209-210


2006ChemEngComm J. Lahann,"Reactive Polymer Coatings for Biomimetic Surface Engineering", Chemical Engineering Communications (2006) 193, 1457-1468. (invited review).



L. Bondarenko, J.W. Kampf, J. Lahann, "The Synthesis of Brominated Tetrafluoro[2.2]paracyclophanes", European Journal of Organic Chemistry (2006) 5499-5504.



M. Yoshida, R. Langer, A. Lendlein, and J. Lahann, "From advanced biomedical coatings to intelligent biomaterials", Polymer Reviews (2006) 46, 347-375.

2006-Polymer International

J. Lahann, "Vapor-Based Polymer Coatings For Potential Biomedical Applications", Polymer International (2006) 55 (12), 1361-1370. 

Y. Elkasabi, H.Y. Chen, J. Lahann, "Multi-potent polymer coatings based on chemical vapor deposition co-polymerization", Advanced Materials (2006) 18, 1521-1526.

Using chemical vapor deposition co-polymerization, we have developed a simple strategy towards multi-functional surfaces presenting two different biological ligands in controllable ratios. These modularly designable polymer coatings are applicable to a wide range of biomedical devices including microanalytical or diagnostic systems.

K.H. Roh, D.C. Martin, J. Lahann, "Triphasic Nanocolloids", Journal of the American Chemical Society (2006) 128, 21, 6796-6797.




H. Nandivada, H.Y. Chen, L. Bondarenko, J. Lahann, "Reactive polymer coatings that "click"", Angewandte Chemie International Edition (2006) 45, 20, 3360-3363.

Vapor-based alkyne-containing polymer coatings have showed remarkable reactivity towards azides via the chemoselective Huisgen’s 1,3-dipolar cycloaddition. As a flexible bioconjugation platform, this regioselective immobilization strategy could be applicable in the design of biofunctional surfaces for diagnostics (e.g. microarrays), biosensors, and biomedical device coatings. 



H.Y. Chen, Y. Elkasabi, J. Lahann, "Surface modification of confined microgeometries via vapor-deposited polymer coatings", Journal of the American Chemical Society (2006) 128, 1, 374-80.

Chemical vapor deposition polymerization within confined geometries.

Y. Wang, Z. Tang, P. Podsiadlo, Y. Elkasabi, J. Lahann, N.A. Kotov, "Mirror-Like Photoconductive Layer-by-Layer Thin Films of Te Nanowires: The Fusion of Semiconductor, Metal, and Insulator Properties", Advanced Materials (2006) 18, 518-522.

Corresponding author: Nicholas A. Kotov.

2006-Biomedical Microdevices

J.M. Wu, Y. Chung, K.J. Belford, G.D. Smith, S. Takayama, J. Lahann. "A Surface-Modified Sperm Sorting Device with Long-Term Stability", Biomedical Microdevices (2006) 8, 99-107.

K.-H. Roh, D.C. Martin, J. Lahann, "Multiphasic nanocolloids based on electrified co-jetting", PMSE Preprints (2006) 95, 987-988

H.-Y. Chen, J.M. Rouillard, E. Gulari, J. Lahann, "High-precision surface of three-dimensional geometries using photodefinable, ultrathin polymer coatings", PMSE Preprints (2006) 95, 125-126.

Y. Elkasabi, H.-Y. Chen, J. Lahann, "Multifunctional Coatings based on chemical vapor deposition co-polymerization", Polymer Preprints (2006) 47, 1093.

H. Nandivada, H.-Y. Chen, J. Lahann, "Reactive Coatings for surface modification via spatially controlled Husigen 1,3-dipolar cycloaddition", Polymer Preprints (2006) 47, 348.

K.-H. Roh, J. Lahann, "Thermal imidazation combined with electrified co-jetting for the synthesis of water stable biphasic nanocolloids", Polymer Preprints (2006) 47, 1093.


K.H. Roh, D.C. Martin, J. Lahann, "Biphasic Janus particles with nanoscale anisotropy", Nature Materials (2005) 4, 759-763.

Anisotropic material distribution can be induced at the nanometer scale by the use of electrified jetting. Side-by-side dual capillaries were employed to expose two distinct parallel polymer solutions to an electrical field simultaneously. The individual phases of the resulting polymer-based Janus particles can be independently loaded with biomolecules or selectively modified with reactive ligands.

H. Nandivada, H. Y Chen, J. Lahann, "Vapor-Based Synthesis of Poly[(4-formyl-p-xylylene)-co-(p-xylylene)] and Its Use for Biomimetic Surface Modifications", Macromolecular Rapid Communications (2005) 26, 1794-1799.

The synthesis of a reactive polymer, poly(4-formyl-p-xylylene-co-p-xylylene), via chemical vapor deposition (CVD) polymerization is reported. Moreover, usefulness of these polymer coatings for biomimetic surface modifications is demonstrated.

2005Analytical Chemistry HY Chen

H.Y. Chen, J. Lahann, "Fabrication of Discontinuous Surface Patterns within Microfluidic Channels Using Photodefinable Vapor-Based Polymer Coatings", Analytical Chemistry (2005) 77, 6909-6914.

Spatially controlled protein adsorption via photopatterning of reactive coatings deposited within microchannels.


J. Lahann, R. Langer, "Smart Materials with Dynamically Controllable Surfaces", MRS Bulletin (2005) 30, 3, 185-188.


H.Y. Chen, J. Lahann, "Preparation of Non-Fouling Coatings Made by Chemical Vapor Deposition Polymerization", Polymer Preprints (2005) 46(2), 1280-1281

J. Lahann, "Bio-Functional Polymer Coatings Based on Chemical Vapor Deposition", PMSE Preprints (2005) 92, 39-40.


2004 Advanced Materials

K.Y. Suh, R. Langer, J. Lahann, "A novel photodefinable reactive polymer coating and its use for microfabrication of hydrogel elements", Advanced Materials (2004) 16, 16, 1401-1405.




K. Schürmann, J. Lahann, J. Meyer, H. Klosterhalfen, D. Vorwerk, D. Klee, R.W. Günther, "Biologic Response to Polymer-Coated Stents Examined in a Iliac Artery Sheep Model", Radiology (2004) 230, 1, 151-162.








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