· H-Y Lee, J.W. Kampf and E.N.G. Marsh (2008) “Metal-peptide framework compounds that extend in one and two dimensions” Crystal Growth and Design.  In press

· L.M. Gottler, H-Y Lee, C.E. Shelburne, A. Ramamoorthy and E.N.G. Marsh (2008) “Enhancing the biological activity of an antimicrobial peptide using fluorous amino acids” ChemBioChem.  In press

· M.Yoon, A. Kalli, H.-Y. Lee, K. Hakansson and E.N.G. Marsh (2007) “Intrinsic Deuterium Kinetic Isotope Effects in Glutamate Mutase Measured by an Intramolecular Competition Experiment” Angew. Chem. 46, 8455 – 8459 [PDF]

· H-Y Lee, M. Yoon and E.N.G. Marsh (2007) “Synthesis of mono- and di-deuterated (2S,3S)-3-methylaspartic acids to facilitate measurement of intrinsic kinetic isotope effects in enzymes” Tetrahedron, 63, 4663-4668 [PDF]

· A. Patwardhan and E.N.G. Marsh (2007) “Changes in the Free Energy Profile of Glutamate Mutase Imparted by the Mutation of an Active Site Arginine Residue to Lysine” Arch. Biochem. Biophys., 461 194-199

· M-C. Cheng and E.N.G. Marsh (2007) “Evidence for Coupled Motion and Hydrogen Tunneling the Reaction Catalyzed by Glutamate Mutase” Biochemistry, 46, 883-888 [PDF]

· G. M. Sandala, D. M. Smith, E. N. G. Marsh and L. Radom (2007) “Towards an Improved Understanding of the Glutamate Mutase System” J. Am. Chem. Soc., 1291623-1633 [PDF]

· L. Li and E.N.G. Marsh (2006) “Mechanism of Benzylsuccinate Synthase Probed by Substrate Exchange” J. Am. Chem. Soc., 128, 16056 -16058 [PDF]

· L. Li and E.N.G. Marsh (2006) “Deuterium isotope effects in the unusual addition of toluene to fumarate catalyzed by benzylsuccinate synthase” Biochemistry, 45, 13932 - 13938 [PDF]

· M. Yoon, A. Patwardhan, C. Qiao, S. Mansoorabadi, A.L. Menefee, G.R. Reed and E.N.G. Marsh (2006) “The reaction of adenosylcobalamin-dependent glutamate mutase with 2-thioglutarate” Biochemistry, 45, 11650 - 11657 [PDF]

· H.-Y. Lee, K.-H. Lee, H. M. Al Hashimi and E.N.G. Marsh (2006) “Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine” J. Am. Chem. Soc., 128, 337-343 [PDF]

· K-H. Lee, C. Cabello, L. Hemmingsen, E.N.G. Marsh and V.L. Pecoraro (2006) “Using nonnatural amino acids to control metal-coordination number in three-stranded coiled coils” Angew. Chem. Int. Edn., 45 2864 - 2868 [PDF]

· A.J. Brooks, C.C. Fox, E.N.G. Marsh, M. Vlasie, R. Banerjee and T. C. Brunold (2005) “Electronic structure studies of the adenosylcobalamin cofactor in glutamate mutase” Biochemistry, 44, 15167-15181 [PDF]

· C. Qiao and E.N.G. Marsh (2005)  “Mechanism of benzylsuccinate synthase:  stereochemistry of toluene addition to fumarate and maleate ”J. Am. Chem. Soc., 127, 8608-8609  [PDF]

· R.J. Sension, A.D. Harris, A. Stickrath, A.G. Cole, C.C. Fox, and E.N.G. Marsh (2005) “Time-resolved measurements of the photolysis and recombination of adenosylcobalamin bound to glutamate mutase” J. Phys. Chem. B, 109, 18146-18152 [PDF]

· M.-C. Cheng and E.N.G. Marsh (2005) “Isotope effects for the transfer of deuterium between glutamate and 5’-deoxyadensosine in adenosylcobalamin-dependent glutamate mutase ” Biochemistry, 44, 2686-2691 [PDF]

· K.-H. Lee, H.-Y. Lee, M.S. Slutsky, J.T. Anderson and E.N.G. Marsh (2004) “Fluorous effect in proteins: De novo design and characterization of a four-alpha-helix bundle protein containing hexafluoroleucine” Biochemistry, 43, 16277-16284 [PDF]

· E.N.G. Marsh, A. Patwardhan and M.S. Huhta (2004) “S-adenosylmethionine radical enzymes” Bioorganic Chem, 32, 326-340 [PDF]

· K.-H. Lee, M. Matzapetakis, S. Mitra, E.N.G. Marsh and V.L. Pecoraro (2004) “Control of metal coordination number through subtle sequence modifications of designed peptides” J. Am. Chem. Soc, 126, 9178-9179 [PDF]

· M.S. Slutsky and E.N.G. Marsh (2004) “Contribution of cation-pi interactions to protein folding studies in a model coiled-coil peptide” Protein Science, 13, 2244-2251 [PDF]

· L Xia, D.P. Ballou and E.N.G. Marsh (2004) “The role of Arg100 in the active site of adenosylcobalamin-dependent glutamate mutase” Biochemistry, 43 3238-3245 [PDF]

· R.J. Sension, A.G. Cole, A.D. Harris, C.C. Fox, N. Woodbury, S. Lin, and E.N.G. Marsh (2004) “Photolysis and Recombination of Adenosylcobalamin Bound to Glutamate Mutase” J. Am. Chem. Soc, 126, 1598-1599 [PDF]

· M.-C. Cheng and E.N.G. Marsh (2004) “Pre-steady state measurement of intrinsic secondary tritium isotope effects associated with the homolysis of adenosylcobalamin and the formation of 5’-deoxyadensosine in glutamate mutase ” Biochemistry, 43, 2155-2158 [PDF]

· G. Sciara, S.G. Kendrew, A.E. Miele, E.N.G. Marsh, L. Federici, F. Malatesta, G. Schimperna, C. Savino and B. Vallone (2003) “The structure of ActVA-Orf6: a novel type of monooxygenase involved in actinorhodin biosynthesis” EMBO J. 22, 205-215 [PDF]

· E.N.G. Marsh and W.F. DeGrado (2002) “Non-covalent self assembly of a heterotetrameric diiron protein” Proc. Natl. Acad. Sci. 99, 5150-5154 [PDF]

· P. Madhavapeddi, D.P. Ballou and E.N.G. Marsh (2002) “Pre-Steady State Kinetic studies on the Gly171Gln Active Site Mutant of Adenosylcobalamin-dependent Glutamate Mutase” Biochemistry, 41, 15802-15809 [PDF]

· J. T. Anderson, P. L. Toogood and E.N.G. Marsh (2002) “A short and efficient synthesis of L-5,5,5,5’,5’,5’-hexafluoroleucine from N-Cbz-L-serine ” Org. Lett. 4, 4281-4283 [PDF]

· M. S. Huhta, D. Ciceri, B.T. Golding and E.N.G. Marsh (2002) “A novel reaction between adenosylcobalamin and 2-methyleneglutarate catalyzed by glutamate mutase” Biochemistry 41, 3200-3206. Click here to view in HTML.

· H-W. Chih, I. Roymoulik, M. S. Huhta, P. Madhavapeddi and E.N.G. Marsh (2002) “Adenosylcobalamin-dependent glutamate mutase:  pre-steady-state kinetic methods for investigating the reaction mechanism” Methods. Enzymol., 354, 380-399

· H.-W. Chih and E.N.G. Marsh (2001) “Tritium partitioning and isotope effects in adenosylcobalamin-dependent glutamate mutase” Biochemistry, 40, 13060-13067. Click here for an article in HTML. 

· P. Madhavapeddi and E.N.G. Marsh (2001) “The role of the active site glutamate in the rearrangement of glutamate to 3-methylaspartate catalyzed by adenosylcobalamin-dependent glutamate mutase” Chem. Biol, 8, 1143-1149. Click here for HTML.

· M. S. Huhta, H.-P. Chen, C. Hemann, C.R. Hille and E.N.G. Marsh (2001) “Protein-Coenzyme interactions in adenosylcobalamin-dependent glutamate mutase” Biochem. J., 355, 131-137. Click here for HTML.

· M. Tollinger, R. Konrat, C. Eichmuller, M Huhta, E.N.G. Marsh and B. Krautler (2001) “The B₁₂-binding subunit of glutamate mutase from Clostridium tetanomorphum traps the nucleotide moiety of coenzyme B₁₂” J. Mol. Biol., 309, 777-791. Click here to view in HTML. 

· B. Hoffman, M. Tollinger, R. Konrat, M. Huhta, E.N.G. Marsh and B. Krautler (2001) “A protein pre-organized to trap the nucleotide moiety of B₁₂: refined solution structure of the B₁₂-binding subunit of glutamate mutase from Clostridium tetanomorphum” ChemBioChem, 2, 643-655. Click here for the article in HTML.

· E.N.G. Marsh and C. L. Drennan (2001) “Adenosylcobalamin-dependent isomerases: new insights into structure and mechanism” Curr. Opin. Chem. Biol., 5, 499-505. Click here for HTML

· H.-W. Chih and E.N.G. Marsh (2000) “Identification and kinetic competence of glycyl radical as an intermediate in the reaction catalyzed by adenosylcobalamin-dependent glutamate mutase” J. Am. Chem. Soc, 122, 10732-10733. Click here for HTML. 

· I. Roymoulik, N. Moon, W.R. Dunham, D.P. Ballou and E.N.G. Marsh (2000) “Rearrangement of L-2-hydroxyglutarate to L-threo-3-methylmalate catalyzed by adenosylcobalamin-dependent glutamate mutase” Biochemistry, 39, 10340-10346, Click here for HTML.

· E.N.G. Marsh (2000) “Glutamate mutase” Bioorganic Chemistry, 28, 176-189. Click here to view the PDF.

· E.N.G. Marsh (2000) "Towards the non-stick egg:  designing fluorous proteins” Chemistry and Biology, 7, R153-R157. Click here for an HTML article.

· E.N.G. Marsh and D.E. Holloway (2000) “Adenosylcobalamin-dependent enzymes” Subcellular Biochemistry, 35, 351-403

· S.G. Kendrew, L. Federici, C. Savino, A. Miele, E.N.G. Marsh and B. Vallone (2000) “Crystallization and preliminary x-ray diffraction studies of a monooxygenase from Streptomyces coelicolor A3(2) involved in the biosynthesis of the polyketide actinorhodin” Acta. Crystalographica, 56, 481-483, Click here for HTML.

· E.N.G. Marsh (1999) “Cobalamin dependent enzymes” Essays in Biochemistry, 34, 139-154, Click here for details on ordering

· H.-W. Chih and E.N.G. Marsh (1999) "Pre-steady state kinetic investigation of intermediates in the reaction catalyzed by adenosylcobalemin-dependent glutamate mutase" Biochemistry, 38, 13684-13691. Click Here to view in full, HTML

· I. Roymoulik, H.-P. Chen, and E.N.G. Marsh (1999) "The Reaction of the Substrate Analog 2-Ketoglutarate with Adenosylcobalamin-dependent Glutamate Mutase" J. Biol. Chem. 274, 11619-11622. Click Here to view article in HTML. 

· E.N.G. Marsh and D.P. Ballou (1998) "Free energy profile of the glutamate mutase-catalyzed reaction: kinetics of substrate-induced homolysis of adenosylcobalamin and the partitioning of reaction intermediates" Biochemistry, 37, 11864-11872. Click Here to view the the full article in HTML. 

· M. Tollinger, R. Konrat, B.H. Hilbert, E.N.G. Marsh and B.Krautler (1998) "How a protein prepares for B12-binding: structure and dynamics of the B12-binding subunit of glutamate mutase" Structure, 6, 1021-1033. Click here for the HTML.

· H.-P. Chen and E.N.G. Marsh (1997) "Adenosylcobalamin-dependent glutamate mutase: characterization of an engineered enzyme with simplified quaternary structure and kinetics" Biochemistry, 36, 14939-14945. Click Here to view the full article in HTML. 

· H.-P. Chen and E.N.G. Marsh (1997) "How enzymes control the reactivity of adenosylcobalamin: effect on coenzyme-binding and catalysis of mutations in the conserved histidine-aspartate pair of glutamate mutase" Biochemistry 36, 7884-7889. Click Here to view the full article in HTML. 

· S.G. Kendrew, D.A. Hopwood and E.N.G. Marsh (1997) "Physical and mechanistic characterization of the novel mono-oxygenase encoded by the actVA-orf6 gene of Streptomyces coelicolor" J. Bacteriol. 179, 4305-4310. Click here to view PDF of full article.

· E.N.G. Marsh, D.E. Holloway and H.-P. Chen (1997) "Glutamate mutase" Chapter 16 in Vitamin B₁₂ and B₁₂-Proteins, (B. Krautler, D. Arigoni and B.T. Golding Eds). Wiley-VCH, Berlin.

· D.E. Holloway, H.-P. Chen and E.N.G. Marsh (1996) "Carboxymethylation of MutS-cysteine-15 specifically inactivates adenosylcobalamin-dependent glutamate mutase -- examination of the role of this residue in coenzyme-binding and catalysis" J. Biol Chem., 271, 29121-29125. Click Here to view the full article in HTML.

· D.E. Holloway, S.E. Harding and E.N.G. Marsh (1996) " Adenosylcobalamin-dependent glutamate mutase: properties fusion protein in which the cobalamin-binding subunit is linked to the catalytic subunit" Biochem. J., 320, 825-830. Click Here for the abstract.

· E.N.G. Marsh (1995) "Tritium isotope effects in adenosylcobalamin-dependent glutamate mutase: Implications for the Mechanism" Biochemistry, 34, 7542-7547. Click here to view article in PDF.

· E.N.G. Marsh (1995) "A radical approach to enzyme catalysis" Bioessays 17, 431-441.

· S.G. Kendrew, Harding, S.E., D.A. Hopwood and E.N.G. Marsh (1995) "The actVB gene from the actinorhodin biosynthetic cluster encodes a FMN:NADH oxidoredutase: expression, purification and characterization of the recombinant enzyme" J. Biol Chem, 270, 17339-17342. Click Here to view the article in HTML.

· D.E. Holloway and E.N.G. Marsh (1994) "Adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum: over-expression in E.coli, purification and characterization of the recombinant enzyme" J. Biol. Chem. 269, 20425-20430. Click Here to view the article in PDF.

· D.E. Holloway and E.N.G. Marsh (1993) "Cloning and sequencing of glutamate mutase component E from Clostridium tetanomorphum" FEBS Lett. 317, 44-48.

· E.N.G. Marsh and S.E. Harding (1993) "Methymalonyl-CoA mutase from Propionibacterium shermanii: characterization of the cobalamin inhibited form and subunit-cofactor interactions studied by analytical ultracentrifugation" Biochem. J. 290, 551-555. Abstract is available here

· E.N.G. Marsh and D.E. Holloway (1992) "Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum: homologies with other cobalamin-dependent enzymes" FEBS Lett. 310, 147-149.