faculty
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Kate Carroll
Assistant
Professor of Chemistry, Research Assistant Professor, Life Sciences Institute
Ph.D., Stanford University
Biochemistry, Bioinorganic
Chemistry, and Chemical Biology
Phone: (734) 615-2739
E-mail: katesc@umich.edu
Research
Group
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The Carroll group in the
Life Sciences Institute and the Department of Chemistry
and at the University of Michigan integrates biochemistry,
organic chemistry, and chemical biology approaches to
address problems relevant to human health and disease.
Our research has two major focuses: Microbial
sulfur metabolism and oxidation biology. In the host-pathogen
arena, we are investigating sulfur metabolic pathways
that allow Mycobacteria to persist in the human host.
Our efforts in oxidation biology are directed at developing
new chemical tools to identify and study post-translational
modifications associated with cellular redox signaling
and oxidative stress.
A hallmark of our program is
the ability to make new molecules and use them for a targeted
function. This philosophy allows students and postdocs
in the group to take their own chemistry-based projects
all the way to the biological finish line. We synthesize
a variety of molecules ranging from activity-based chemical
probes, small-molecule inhibitors, non-natural peptides,
and also use directed evolution to generate novel catalysts.
In turn, we apply a variety of biological, structural,
and spectroscopic techniques to evaluate the properties
and capabilities of newly synthesized molecules and catalysts
in living cells.
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AWARDS
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2006 Biological Sciences Scholar Program
- 2006 Leukemia and Lymphoma Society
Special Fellow Award
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2003 Damon Runyon Postdoctoral
Fellow Award
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REPRESENTATIVE PUBLICATIONS
- Rheddie, K. G., Seo,
Y., Muse III, W. B., Leonard, S. & Carroll, K. S. (2008). A chemical approach for detecting sulfenic acid-modified proteins in living cells. Mol. BioSyst., DOI: 10.1039/b719986d Journal Link | Chemical Biology News | Nature Chemical Biology Highlight
- Chang, M. W., Belew, R. K., Carroll, K. S. ,
Olson, A. J. & Goodsell, D. S (2008). Empirical
entropic contributions in computational docking:
Evaluation in APS reductase complexes. J. Comp. Chem., DOI 10.1002/jcc.20936a Pubmed Link
- Bhave, D. P., Muse III,
W. B. & Carroll, K. S. (2007). Drug targets in mycobacterial sulfur metabolism. Infectious Disorders - Drug Targets, 7, 140-158. Pubmed Link
- Chartron, J., Shiau,
C., Stout, C. D., & Carroll, K. S. (2007). 3'-Phosphoadenosine-5'-phosphosulfate reductase in complex with thioredoxin: a structural snapshot in the catalytic cycle. Biochemistry Accelerated Publication 46, 3942-3951. Pubmed Link
- Gao, H., Leary, J. A., Carroll, K. S.,
Bertozzi, C. R., & Chen, H. (2007). Noncovalent
complexes of APS Reductase from Mycobacterium tuberculosis: delineating a mechanistic model using ESI-FTICR MS. J. Am. Soc. Mass Spectrom., 18, 167-178. PubMed Link | On the Cover
- *Charton, J., *Carroll, K. S.,
Shiau, C., Gao, H., Leary, J. A., Bertozzi, C.
R., & Stout, C. D. (2006). Substrate recognition,
protein dynamics and novel iron-sulfur cluster
in Pseudomonas aeruginosa APS reductase. J. Mol. Bio., 364, 152-169. PubMed Link
- Carroll, K. S.,
Gao, H., Chen, H. Y., Leary, J. A., & Bertozzi,
C. R. (2005). Investigation of the iron-sulfur
cluster in Mycobacterium tuberculosis APS reductase: Implications for substrate binding and catalysis. Biochemistry, 44, 14647-14657. PubMed Link | Biochemistry Hot Article
- Carroll, K. S.,
Gao, H., Chen, H. Y., Stout, C. D., Leary, J.
A., & Bertozzi, C. R. (2005). A conserved
mechanism for sulfonucleotide reduction. PLOS Biology, 3, 1418-1435. PubMed Link | PLoS Synopsis | Nature Chemical Biology Highlight
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