BIOCHEMISTRY CONCENTRATION RESEARCH FACULTY
Biochemistry - http://www.biochem.med.umich.edu/
Chemistry - http://www.umich.edu/~michchem/
Biophysics - http://biop.lsa.umich.edu/
**Additional Information in 1500 Chem
Hashim Al-Hashimi, Associate Professor, 4028a Chem 1055, (734-615-3361), hashimi@umich.edu. Our laboratory applies solution state NMR spectroscopy to investigate the molecular basis of RNA function in processes ranging from transcriptional activation and translation to genome packaging and reverse transcription. We make extensive use of new NMR techniques involving measurements of residual dipolar couplings in determining global aspects of RNA structure, dynamics and interaction. A central goal is to develop and apply NMR techniques for determining high-resolution RNA structures as a function of time and other reaction coordinates. Research involves biochemical preparation/purification of isotopically labeled RNA samples, design of NMR experiments, and development of theoretical frameworks for analyzing data.
Philip C. Andrews, Professor 1198 NIB 5404, (734-763-3130), andrewsp@umich.edu. Intracellular Proteases, Neuropeptides, and Peptide Hormones; Structure, Processing, and Function of Bioactive Peptides, Using Novel Molecular Biology and Biochemical Approaches .
David P. Ballou, Professor. 4220C MSRB3 5606, (734-764-9582) dballou@umich.edu . Mechanism of Biological Reactions with Oxygen, Especially Metalloproteins and Flavoproteins; Physical Studies, Including Rapid Reaction Techniques and Instrumentation Development.. A Central Theme is the Oxygenation of Organic Compounds, Including Hazardous Wastes. Use of Genetic Technologies to Engineer Site Directed Mutations that are Useful in Probing the Role of the Protein Residues in Catalysis.
James Bardwell, Professor. 4004 Nat Sci 1048, (734-764 8020), jbardwel@umich.edu. Use of Genetic, Structural, and Biophysical Tools in the Investigation of the Machinery that Drives Protein Folding: Catalysts Responsible for Disulfide Bond Formation and Heat Shock Proteins that Act as "Chaperones" in the Folding Process. **
Daniel Bochar, Assistant Professor. 3301E MSRB III 5606, (734- 763-6991), dbochar@umich.edu. The DNA of eukaryotes is packaged into chromatin by the wrapping of ~146 bp of DNA around a core histone octamer. This packaging serves to compact the DNA into the nucleus, but also presents a barrier to cellular processes such as transcription, replication and repair. Projects in our laboratory focus on defining the mechanisms of higher eukaryotic gene regulation through the modification of chromatin structure. Importantly we want to discover how these pathways are linked to development and neoplastic transformation.
Heather H. Carlson, Associate Professor. Chemistry and Medicinal Chemistry. 2555 CCL 1065, (734-615-6841), carlsonh@umich.edu. Computational Chemistry, Theoretical Biophysics
David E. Engelke , Professor. 3200D MSRB 3 5606, (734-763-0641), engelke@umich.edu . Regulation of Eukaryotic Gene Expression at the Levels of Transcription and RNA Processing; Structure and Function of Catalytic RNA. **
Carol A. Fierke, Professor. 4525 Chem 1055, (734-936-2678), fierke@umich.edu . Biological Catalysis; Molecular Recognition, Enzyme Engineering.
Robert S. Fuller, Professor. 3220 C MSRB 3 5606, (734-936-9764), bfuller@umich.edu . Proteolytic Processing, Protein Localization and Macromolecular Transport in the Secretory Pathway; Yeast Cell Biology; Structure, Mechanism and Specificity of Proteases . **
Ari Gafni, Professor. 3204 Chem 1055, (734-615-1964) arigafni@umich.edu . Aging Phenomena at Molecular Level; Structure-Function Relationships in Biological Molecules.
Gary D. Glick, Professor. Program Director, Chemical Biology. 2819 Chem 1055, (734-764-4548), gglick@umich.edu . Bioorganic Chemistry, Molecular Recognition.
Daniel J. Goldman, Professor. 5045 BSRB 2200, (734-936-2057), neuroman@umich.edu. Acetylcholine Receptor Gene Expression at the Neuromuscular Junction; Synaptogenesis; Sensory Transduction Processes; Neuroreceptors.
Kristina Hakansson, Associate Professor. 4521 Chem 1055, (734-615-0570), kicki@umich.edu . Our research focuses on applying state-of-the-art mass spectrometric techniques (a hybrid quadrupole-Fourier transform ion cyclotron resonance mass analyzer equipped with electron capture and infrared multiphoton dissociation) to the following areas: 1) identification and characterization of protein posttranslational modifications; 2) mapping macromolecular contact surfaces through hydrogen/deuterium exchange; and 3) exploration of the gas-phase fragmentation behavior of various biomolecules following ion-electron interactions.
Ursula Jakob, Associate Professor, 4041B Nat. Sci. 1048 (734-615-1286), ujakob@umich.edu . Molecular biology of defenses against heat and oxidative stress.
Randal J. Kaufman, Professor. 4570 MSRB 2 0650, (734-763-9037), kaufmanr@umich.edu. Regulation of Protein Synthesis and Secretion. Molecular Biology of Factor VIII and Gene Therapy for Hemophilia A .
Robert Kennedy, Professor. 4815 Chem 1055, (734-615-4363), rtkenn@umich.edu. Analytical and bioanalytical.
Tom Kerppola, Professor. 4570A MSRB 2 0650, (734-764-3554), kerppola@umich.edu . Regulation of Gene Expression by Proto-Oncogene Transcription Factors; Transcription Factor Interactions and Protein Induced Changes in DNA Structure. **
Daniel J. Klionsky, Professor. 6036 LSI 2216 (734-615-6556) , klionsky@umich.edu. Protein Targeting, Organelle Biogenesis and Cellular Homeostasis in Yeast.
Masato Koreeda, Professor. 2525 Chem 1055, (734-764-7371), koreeda@umich.edu . Organic Synthesis, Bioorganic Chemistry and Medicinal Chemistry. Synthesis of Biological Important Natural Products; Small Organic Molecule-DNA Interaction; Biological Oxidation Mechanism; Chemical Carcinogenesis; Glycobiology.
Raoul Kopelman, Professor. 4744 Chem 1055 (734-764-7541), kopelman@umich.edu . Enzyme-Based Intracellular Fiber-Optic Nanosensors and their In-Vivo Applications; Near-Field Optical Microscopy; Enzyme Kinetics; Energy Transfer in Antenna Supermolecules..
Anna Mapp, Associate Professor. 2815 Chem 1055, (734-615-6862, amapp@umich.edu . Organic Chemistry and Chemical Biology. Development of New Synthetic Methods. Chemical Approaches to the Regulation of Gene Expression. Polymers as Functional Mimics of Transcription Factors.
E. Neil G. Marsh, Professor of Chemistry, Associate Professor of Biological Chemistry. 4537 Chem 1055, (734-763-6096), nmarsh@umich.edu . Enzymes: Structure, Mechanism and Specificity; Protein Engineering and Molecular Recognition. **
Rowena G. Matthews, Professor of Chemistry, Associate Professor of Biological Chemistry, Research Professor, Life Sciences Institute. 4002 LSI 2216, (734-764-5257), rmatthew@umich.edu. Mechanisms of Folate-Dependent Enzymes; Regulation of Folate Metabolism. **
Jairam K. Menon, Professor. 6428 MSI 5606, (734-764-8142), kmjmenon@umich.edu. Signal Transduction Through "G" Protein Coupled Receptors; Molecular Aspects of Hormone Action.
Mark E. Meyerhoff, Professor. 3306 Chem 1055, (734-763-5916) mmeyerho@umich.edu Membrane Electrodes, Gas Sensors, Analytical Applications of Immobilized Bio-Reagents, Enzyme-Linked Competitive Binding Assays, New Stationary Phases for Liquid Chromatography.
Michael D. Morris, Professor. 4811 Chem 1055, (734-764-7360), mdmorris@umich.edu. Analytical Laser Spectroscopy and Imaging; Electrophoretic Separations.
Richard R. Neubig, Professor. 2220D MSRBIII 5606 (734-764-8165) rneubig@umich.edu, Molecular, cellular, and physiological aspects of signaling by guanine nucleotide binding proteins (G proteins) and G protein coupled receptors.
Ruthann Nichols, Associate Professor. 5301C MSRB 5606, (734-764-4467), nicholsr@umich.edu . Neuropeptide Structure and Function; a Multidisciplinary Study Utilizing Biochemistry, Genetics, Molecular Biology, and Neurobiology. **
Alexander J. Ninfa , Professor.4220A MSRB3 5606, (734-763-8065) aninfa@umich.edu . Signal Transduction and Transcriptional Regulation Mechanisms in Prokaryotes; Nitrogen Regulation.
Patrick J. O’Brien, Assistant Professor. 4220B MSRB 3 5606, (734-647-5821), pjobrien@umich.edu. Mechanistic studies of enzymes involved in DNA repair and replication. We use a variety of biochemical, biophysical, and structural techniques.
Geneva Omann, Associate Professor. 151 Research VAMC 2399, (734-769-7100) gmomann@umich.edu . Mechanism of Activation of Human Neutrophils by Chemoattractants; in Particular, Cytoskeletal Reorganization in Biochemical Pathways Responsible for Initiating and Integrating the Responses.
Bruce Palfey, Assistant Professor, Biological Chemistry. Associate Program Director, Chemical Biology.4220D MSRB3 5606, (734-615-2452), brupalf@umich.edu . Mechanisms of redox enzymes from pyrimidine metabolism, studied by biophysical methods ; inhibitor design.
Vincent L. Pecoraro, Professor. 3823 Chem 1055, (734-763-1519), vlpec@umich.edu Synthetic Inorganic and Bioinorganic Chemistry.
James Penner-Hahn, Professor. 4545 Chem 1055, (734-764-7324), jeph@umich.edu . Use of Spectroscopy, Microscopy, and Electrophoretic Separations to Characterize the Role(s) that Mn and Zn Plays in Biology. Investigations of the Role of Zn in Embryonic Development;Characterization of a Novel Mn Containing Catalase. **
Eran Pichersky, Professor, 4103D Nat. Sci. 1048(734-936-3522), lelx@umich.edu. Molecular biochemistry of metabolism of plant natural products.
Ayyalusamy Ramamoorthy, Professor of Chemistry, Associate Professor and Academic Program Director of Biophysics. 4024 Chem 1055, (734-647-6572), ramamoor@umich.edu . Structural Studies of Biological Molecules.
Mark A. Saper, Associate Professor. 3040 Chem 1055, (734-764-3353), saper@umich.edu . Three-dimensional Structures of Protein Phosphatases and Anti-DNA Autoantibodies Using X-Ray Crystallography . **
Jochen H. Schacht, Professor. 5315 MSI 5616, (734-763-3572), schacht@umich.edu . Neurochemistry; Second Messengers; Biochemical Mechanisms of Hearing Processes and Drug-Induced Hearing Loss. **
Audrey F. Seasholtz, Professor. 5035 BSRB 2200, (734-936-2072), aseashol@umich.edu. Regulation of Expression of the Corticotropin-Releasing Hormone Gene.
Roseanne J. Sension, Professor. 4529 Chem 1055, (734-763-6074), rsension@umich.edu . Physical Chemistry, Ultrafast Laser Spectroscopy and Chemical Reaction Dynamics.
David Sherman, Professor, 4036 LSI 2216. (734-615-9907), davidhs@umich.edu . Molecular genetic, biochemical and bioorganic chemical studies of microbial natural product biosynthesis.
Debra A. Thompson, Professor. 533 Kellogg Eye Center 0714, (734-936-9504), dathom@umich.edu . Molecular studies of signal transduction and gene expression in the retinal pigment epithelium.
Raymond Trievel, Assistant Professor. 4301C MSRB3 5606, (734-647-0889), rtrievel@umich.edu . Elucidating the structure and function of enzymes that catalyze post-translational modifications of proteins, especially those involved in transcriptional regulation and chromatin remodeling, using biochemistry and X-ray crystallography.
Michael D. Uhle, Professor, 5043 BSRB 2200, (734-647-3188), muhler@umich.edu Regulation and Specificity of Serine-Throenine Protein Kinases, Regulation of Calcium Channels and Neurotransmitter Secretion . **
Edwin Vedejs, Professor. 3817 Chemistry 1055, (734-615-2177), edved@umich.edu Organic chemistry and bio-organic chemistry.
Anne B. Vojtek, Associate Professor. 3301C MSRB 3 5606, (734-647-6794), avojtek@umich.edu Regulation and function of small GTPases, including the Ras oncogene. Identification and characterization of protein/protein interactions in growth factor mediated signal transduction pathways.
Nils G. Walter, Associate Professor. 4821 Chem 1055, (734-615-2060), nwalter@umich.edu, Chemical Biology; Folding and Function of Catalytic RNA; Biophysical Chemistry of Nucleic Acids..
Charles H. Williams, Professor Emeritus, 4301B MSRB3 5606, (734-647-6989), chaswill@umich.edu. Relationships of Structure and Mechanism in Flavoproteins; Identification of Amino Acid Residues Involved in Catalysis . **
Charles F. Yocum, Professor. 4103 A Nat Sci 1048, (734-647-0897), cyocum@umich.edu . Biological Chemistry of Photosynthetic Water Oxidation.
Robert Zand, Professor, 4570A MSRB2 1055, (734-764-3554), rzand@umich.edu. Physical Biochemistry of Myelin Proteins and Neuropeptide Y; Synthesis and Properties of Biopolymer Systems; Spectroscopic Determination of Structure Reactivity Relationships of Proteins and Peptides. **
Erik R.P. Zuiderweg, Professor. 3301A Chemistry MSRB3, (734-936-3850), zuiderwe@umich.edu . Study of Structure and Dynamics of Biomolecules and Complexes of Biomolecules in Solution, Using Multi-Dimensional Multi-Nuclear NMR Spectroscopy.