Faculty

Xiaochun Yu, M.D., Ph.D.
Associate Professor

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Research Interests

The research interests of our laboratory include the mechanisms of DNA damage response, chromatin remodeling, epigenetic modifications and their roles in tumorigenesis and development.

Education

1996 M.D., Beijing Medical University, China

2002 Ph.D., Kurume University, Japan

Academic Appointments

1996 –1998 Research Assistant, Life Science Institute, Kurume University Medical School, Japan

2002 –2006 Research Associate, Department of Oncology, Mayo Clinic, Rochester, MN

2006 - 2011 Assistant Professor, Department of Internal Medicine, University of Michigan

2011 - Associate Professor, Department of Internal Medicine, Universisty of Michigan

Honors and Awards

1998 Fellowship, Japanese International Education Society

1999 Fellowship, Japanese Department of Education, Culture, Sports, Science and Technology (Monbusho fellowship award)

2004 Fellowship, AACR-Cancer Research and Prevention Foundation

2006 Individual Investigator Program, The Ovarian Cancer Research Fund

2006 Idea Award, Department of Defense Breast Cancer Research Program

2006 Biological Science Scholar, the University of Michigan

2007 AACR Susan G. Komen Career Developmental Award

2008 American Cancer Society Research Scholar, American Cancer Society

2010 Era of Hope Scholar Award, Department of Defense

Recent Publications

Kim, H., Chen, J. * and Yu, X*. (2007). Ubiquitin-binding protein RAP80 mediates

BRCA1-dependent DNA damage responses. Science. 316, 1202-1205.(* co-corresponding authors)

Liu, Z., Wu, J., and Yu, X. (2007). CCDC98 targets BRCA1 to DNA damage sites. Nature Structural and Molecular Biology. 14, 716-720.

Huen, M., Grant, R., Manke, I., Minn, K., Yu, X. *, Yaffe, M. * and Chen, J. * (2007). The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway. Cell. 131, 901-914. (* co-corresponding authors)

Privette, L.M., Weier, J.F., Nguyen, H.N., Yu, X. and Petty, E.M. (2008). Loss of Chfr in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting the Mitotic Spindle Assembly Checkpoint. Neoplasia.10, 643-652.

Lu, L.Y., Wood, J.L., Minter-Dykhouse, K., Ye L, Saunders, T.L., Yu, X. * and Chen. J.* (2008). Polo-like Kinase 1 is Essential for Early Embryonic Development and Tumor Suppression. Molecular and Cellular Biology. 28, 6870-6876. (* co-corresponding authors)

Lu, L.Y., Wood, J.L., Minter-Dykhouse, K., Ye L, Saunders, T.L., Yu, X. * and Chen. J.* (2008). Aurora A is Essential for Early Embryonic Development and Tumor Suppression. Journal of Biological Chemistry, 283, 31785-31790. (* co-corresponding authors)

Wu, J., Huen, M., Lu, L.Y., Ye, L., Dou, Y., Ljungman, M., Chen, J. and Yu, X. (2009). Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Molecular and Cellular Biology. 29, 849-860.

Lu, L.Y. and Yu, X. (2009). The balance of Plk1 in tumorigenesis. Cell Division, 4:4. Review

Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. * and Yu, X. * (2009). PALB2 links BRCA1 and BRCA2 in the DNA damage response. Current Biology, 19, 524-529. (* co-corresponding authors)

Huang, J., Huen, M.S., Kim, H., Leung, C.C., Glover, J.N., Yu, X. and Chen, J. (2009). RAD18 transmits DNA damage signalling to elicit homologous recombination repair.Nature Cell Biology. 11, 592-603.

Wu, J., Prindle, M.J., Dressler, G.R. * and Yu, X. * (2009). PTIP regulates 53BP1 and SMC at the DNA damage sites. Journal of Biological Chemistry, 284, 18078-18084. (* co-corresponding authors)

Zhang, F., Wu, J. and Yu, X. (2009). Intergrator3, a partner of SSB1, participates in the DNA damage response. Journal of Biological Chemistry, 284, 30408-30415.

Lu, L.Y., Wu, J., Ye, L. Gavrilina, G.B., Saunders, T.L. and Yu, X. (2010). RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell. 18, 371-384.

Wu, J., Lu, L.Y. and Yu, X. (2010). Role of BRCA1 in DNA damage response. Protein&Cell.1, 117-123. Review.

Li, X., Corsa C.A., Pan, P.W., Wu, L., Ferguson, D., Yu, X., Min, J., and Dou, Y. (2010). MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Molecular and Cellular Biology 30:5335-5347.

Jia, L., Bickel, J.S., Wu, J., Morgan, M.A., Li, H., Yang, J., Yu, X., Chan, R.C. and Sun, Y. (2011) RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. Journal of Biological Chemistry. 286:3379-3386.

Zhang, F. and Yu, X. (2011). WAC, a partner of RNF20/40 complex, regulates histone H2B ubiquitination and gene transcription. Molecular Cell. 41: 384-397.

Wu, J., Chen, Y., Lu, L.Y., Wu, Y., Ferguson, D.O. and Yu, X. (2011). Chfr and RNF8
synergistically regulate ATM activation. Nature Structural and Molecular Biology. 18: 761-768.

Lab Members

Post-Doctoral Fellows:
Chunjing Bian
Qiang Chen
Yibin Chen
Mo Li
Chao Liu
Lin-Yu Lu (Charles)
Teng Ma
Yi Xiong
Feng Zhang

Research Technician
Lin Ye

Visiting Professor
Degui Wang

Undergraduate Student
Gautm Korakavi
Henry Kuang

Postdoctoral fellow positions are available. Please contact Dr. Xiaochun Yu at xiayu@umich.edu