The research interests of our laboratory include the mechanisms of DNA damage response, chromatin remodeling, epigenetic modifications and their roles in tumorigenesis and development.
1996 M.D., Beijing Medical University, China
2002 Ph.D., Kurume University, Japan
1996 –1998 Research Assistant, Life Science Institute, Kurume University Medical School, Japan
2002 –2006 Research Associate, Department of Oncology, Mayo Clinic, Rochester, MN
Honors and Awards
1998 Fellowship, Japanese International Education Society
1999 Fellowship, Japanese Department of Education, Culture, Sports, Science and Technology (Monbusho fellowship award)
2004 Fellowship, AACR-Cancer Research and Prevention Foundation
2006 Individual Investigator Program, The Ovarian Cancer Research Fund
2006 Idea Award, Department of Defense Breast Cancer Research Program
Kim, H., Chen, J. * and Yu, X*. (2007). Ubiquitin-binding protein RAP80 mediates
BRCA1-dependent DNA damage responses. Science. 316, 1202-1205.(* co-corresponding authors)
Liu, Z., Wu, J., and Yu, X. (2007). CCDC98 targets BRCA1 to DNA damage sites. Nature Structural and Molecular Biology. 14, 716-720.
Huen, M., Grant, R., Manke, I., Minn, K., Yu, X. *, Yaffe, M. * and Chen, J. * (2007). The E3 ubiquitin ligase RNF8 propagates the DNA damage signal via an ubiquitin-dependent signaling pathway. Cell. 131, 901-914. (* co-corresponding authors)
Privette, L.M., Weier, J.F., Nguyen, H.N., Yu, X. and Petty, E.M. (2008). Loss of Chfr in Human Mammary Epithelial Cells Causes Genomic Instability by Disrupting the Mitotic Spindle Assembly Checkpoint. Neoplasia.10, 643-652.
Lu, L.Y., Wood, J.L., Minter-Dykhouse, K., Ye L, Saunders, T.L., Yu, X. * and Chen. J.* (2008). Polo-like Kinase 1 is Essential for Early Embryonic Development and Tumor Suppression. Molecular and Cellular Biology. 28, 6870-6876. (* co-corresponding authors)
Lu, L.Y., Wood, J.L., Minter-Dykhouse, K., Ye L, Saunders, T.L., Yu, X. * and Chen. J.* (2008). Aurora A is Essential for Early Embryonic Development and Tumor Suppression. Journal of Biological Chemistry, 283, 31785-31790. (* co-corresponding authors)
Wu, J., Huen, M., Lu, L.Y., Ye, L., Dou, Y., Ljungman, M., Chen, J. and Yu, X. (2009). Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Molecular and Cellular Biology. 29, 849-860.
Zhang, F., Ma, J., Wu, J., Ye, L., Cai, H., Xia, B. * and Yu, X. * (2009). PALB2 links BRCA1 and BRCA2 in the DNA damage response. Current Biology, 19, 524-529. (* co-corresponding authors)
Huang, J., Huen, M.S., Kim, H., Leung, C.C., Glover, J.N., Yu, X. and Chen, J. (2009). RAD18 transmits DNA damage signalling to elicit homologous recombination repair.Nature Cell Biology. 11, 592-603.
Wu, J., Prindle, M.J., Dressler, G.R. * and Yu, X. * (2009). PTIP regulates 53BP1 and SMC at the DNA damage sites. Journal of Biological Chemistry, 284, 18078-18084. (* co-corresponding authors)
Zhang, F., Wu, J. and Yu, X. (2009). Intergrator3, a partner of SSB1, participates in the DNA damage response. Journal of Biological Chemistry, 284, 30408-30415.
Lu, L.Y., Wu, J., Ye, L. Gavrilina, G.B., Saunders, T.L. and Yu, X. (2010). RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis. Developmental Cell. 18, 371-384.
Wu, J., Lu, L.Y. and Yu, X. (2010). Role of BRCA1 in DNA damage response. Protein&Cell.1, 117-123. Review.
Jia, L., Bickel, J.S., Wu, J., Morgan, M.A., Li, H., Yang, J., Yu, X., Chan, R.C. and Sun, Y. (2011) RBX1 (RING box protein 1) E3 ubiquitin ligase is required for genomic integrity by modulating DNA replication licensing proteins. Journal of Biological Chemistry. 286:3379-3386.
Postdoctoral fellow positions are available. Please contact Dr. Xiaochun Yu at email@example.com