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Faculty by Interest
Research InterestsTrace Element ResearchWe are developing tetrathiomolybdate (TM) as an anticopper drug for the initial treatment of Wilson’s disease. We are also using “copper lowering” therapy with TM to treat cancer in preclinical models as well as in clinical trials. The mechanism is most likely inhibition of angiogenic cytokines. We have also found in preclinical studies TM will inhibit organ damage from a variety of toxic substances e.g., bleomycin in the lung, carbon tetrachloride, acetaminophen, concanavalin A in the liver, and adriamycin in the heart. The hypothesized mechanism is inhibition of dysregulated inflammatory and fibrotic cytokines. Clinical trials are underway in idiopathic pulmonary fibrosis and psoriasis. Canine ResearchWe are continuing our search for genes that cause canine genetic diseases, currently focusing on hip dysplasia and epilepsy. Education1948 Merrillville High School 1948-52 B.S. Purdue University, West Lafayette, IN 1952-54 Medical School Indiana University, Bloomiington, IN 1954-56 M.D. University of Chicago, Chicago, IL Postgraduate Training1956-57 Internship, University of Chicago Clinics, Chicago, Illinois 1957-58 Fellowship, Postdoctoral Research Fellow of the National Institutes of Health (National Cancer Institute), University of Chicago, Department of Medicine, Chicago, IL 1958-59 Residency, Senior Assistant Resident in Medicine, University of Chicago Clinics, Chicago, IL 1959-63 Research Assistant and Research Associate, Department of Medicine, University of Chicago, working at the Statesville Penitentiary, Joliet, IL 1963-65 Special Research Fellow of the National Institutes of Health (National Institute of Arthritis and Metabolic Disease), University of Michigan, Department of Human Genetics, Ann Arbor, MI Honors and AwardsBorden Award for highest grade average - freshman pharmacy class Phi Eta Sigma, Freshman Honorary Society B.S. Degree with highest honors M.D. Degree with honors 1965-70 USPHS Career Development Award 1976 Distinguished Alumni Award, University of Chicago 1983 Certification of Appreciation from the Wilson's Disease Association 1989 American College of Nutrition Award of Distinction for Outstanding Research 1990 Fellow, Morris Animal Foundation 1998 Raulin Award, International Society for Trace Element Research in Humans 1999 Master Award of the American College of Nutrition 2000 Morton S. and Henrietta K. Sellner Professor of Human Genetics Recent PublicationsAskari FK, Greenson J, Dick RD, Johnson VD and Brewer GJ. Treatment of Wilson's disease with Zinc XVIII. Initial treatment of the hepatic decompensation presentation with trientine and zinc. J Lab Clin Med, 142(6): 385-390, 2003. Brewer GJ. Copper lowering therapy with tetrathiomolybdate produces antiangiogenic, anticancer, antifibrotic and antiinflammatory effects. Semin Integr Med, 1(4):181-190, 2003. Kent MS, Madewell BR, Dank G, Dick R, Merajver SD, Brewer GJ. An anticopper antiangiogenic approach for advanced cancer in spontaneously occurring tumors, using tetrathiomolybdate: a pilot study in a canine animal mode. J Trace Elem Exp Med, 17(1): 9-20, 2004. Carlson MD, Al-Mateen M, Brewer GJ. Atpical Childhood Presentation of Wilson's Disease. Ped Neurol, 30(1): 57-60, 2004. Goodman VL, Brewer GJ, Merajver SD: Copper Deficiency as an Anti-Cancer Strategy. Endocr Relat Cancer, 11(2):255-63, 2004. Burstein E, Ganesh L, Dick RD, van De Sluis B, Wilkinson JC, Klomp LW, Wijemnga C, Brewer GJ, Nabel GJ, Duckett CS. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J, 23(1): 244-54, 2004. Askari FK, Dick R, Mao M, Brewer GJ. Tetrathiomolybdate Therapy Protects Against Concanavalin A and Carbon Tetrachloride Hepatic Damage in Mice. Exp Biol Med, 229(8):857-863, 2004. Brewer GJ. Neurologically Presenting Wilson’s Disease: Epidemiology, Pathophysiology, and Treatment. CNS Drugs, 19(3): 185-92, 2005. Ma S, Hou G, Dick D, Brewer GJ. Tetrathiomolybdate Protects Against Liver Injury from Acetaminophen in Mice. J Appl Res Clin Exp Ther, In press. Lab ProjectsPlease contact Dr. Brewer for information regarding current research projects. Additional Lab LinksLab MembersRobert Dick
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