Pituitary hormone deficiency diseases and adenomas are both common in humans. Many combined hormone deficiencies are caused by transcription factor defects. Lesions in the homeodomain transcription factor gene PROP1 are most prevalent cause of multiple pituitary hormone deficiencies, and defects in PITX2 cause Rieger syndrome, which can include growth hormone deficiency. To understand pituitary development and disease, we study Prop1, PitX2, and other pituitary transcription factor genes using genetically engineered mice. We are also active in identification of genes involved in hearing and skeletal development.
1977 B.S., University of Delaware (Chemistry)
1974-75 Technische Hochschule Darmstadt, W. Germany
1983 Ph.D., Michigan State University (Biochemistry)
1983-1984 Research Associate, Department of Molecular Biology and Microbiology, Case Western Reserve University, Dr. Fritz Rottman
1984-1988 Postdoctoral Fellow, Institute for Cancer Research, Philadelphia, PA & Princeton University, Dr. Shirley Tilghman
Honors and Awards
1989-1991 Basil O'Connor Starter Award
1992-1994 National Alliance for Research on Schizophrenia and Depression, Young Investigator Award
1995 Career Development Award, University of Michigan
1996 Faculty Recognition Award, University of Michigan
2000 Boezi Memorial Alumnus Award in Biochemistry, Michigan State University
2002 NIH Merit Award
Faculty Lectureship Award in Biomedical Research, Universitiy of Michigan
2007 Roy O. Greep Award for Research Excellence from the Endocrine Society
Davis SW, Castinetti F, Carvalho LR, Ellsworth BS, Potok, MA, Lyons RH, Brinkmeier ML, Raetzman LT, Carninci P. Mortensen, AH, Hayashizaki Y, Arnold IJP, Mendonca BB, Brue T, Camper, SA. Molecular mechanisms of pituitary organogenesis in search of novel regulatory genes. Molecular and Cellular Endocrinology, Special Issue: Developing Biology of Endocrine Organs (invited review), 323:4-19, 2010.
Carvalho LR, Brinkmeier ML, Castinetti F, Ellsworth BS, Camper SA. Corepressors TLE1 and TLE3 interact with HESX1 and PROP1. Mol Endocrinol. 24:754-65, 2010.
Mustapha M, Fang Q, Gong T-W, Dolan DF, Raphael Y, Camper SA (corresponding author), Duncan RK. Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants. J. Neuroscience, 29:1212-23, 2009.
Brinkmeier ML, Davis SW, Carninci P, MacDonald JW, Jun Kawai; Debashis Ghosh; Yoshihide Hayashizaki; Robert H Lyons; Camper SA. Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics 93:449-460, 2009.
Cha KB, Karolyi IJ, Hunt A, Wenglikowski AM, Wilkinson JE, Dolan DF, Dootz G, Finnegan AA, Seasholtz AF, Hankenson K, Siracusa LD, Camper SA. Skeletal dsyplasia and male infertility locus on mouse chromosome 9. Genomics 83:951-60.2004.
Differentiation of embryonic stem cells into hormone producing cells.
Functional test of novel genes in zebrafish pituitary development.
Homeobox genes in pituitary functions.
Cloning of skeletal dysplasia mutants.
Role of individual genes and thyroid hormone in development of normal hearing.
Additional Lab Links
Department of Human Genetics
Camper Lab Home Page
Cellular and Molecular Biology Program
Michelle Brinkmeier, M.S., University of Michigan
Frederic Castinetti, M.D., Ph.D., Faculte de medecine de Marseille, Universite de la Mediterranee, Marseille, France
Shannon W. Davis, Ph.D., Postdoctoral Research Fellow
Michelle T. Fleming, M.S., University of Michigan
Krista Geister, M.S., Ph.D., Student in Cellular and Molecular Biology
Qing Fang, Ph.D. Student in Human Genetics
Peter Gergics, M.D., Ph.D., Semmelweiss University, Budapest, Hungary
Maria Ines Perez Millan, Ph.D., Universidad Nacional de Buenos Aires, Argentina
Thomas J. Jones - Undergraduate Student Assistant