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Faculty
Research InterestsThe research program in our lab centers on genetic studies of blood coagulation and thrombosis. The lab has a long-standing interest in von Willebrand factor (VWF), the genetics of von Willebrand Disease (VWD), and the plasminogen activation (PA) system (particularly the role of plasminogen activator inhibitor-1 (PAI1)). Current work focuses on the in vivo analysis of coagulation system function in transgenic mouse models and the identification of novel genes contributing to human bleeding and clotting disorders. Most recently, the lab has begun a major effort applying mouse genetic approaches to characterize novel modifier genes for thrombosis and bleeding. Education1967-1970 Union High School, Union, New Jersey 1970-1974 Yale University, New Haven, Connecticut; B.A., (Magna Cum Laude) 1974-1977 Duke University Medical School, Durham, North Carolina; M.D. Postdoctoral Training1977-1978 Resident, Presbyterian Hospital, San Francisco, CA (Pathology) 1978-1981 Intern/Resident, Peter Bent Brigham Hospital, Boston, MA (Internal Medicine) 1981-1984 Fellow, Harvard Medical Area Training Program in Hematology and Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA Honors and Awards1974 Magna Cum Laude, Yale University 1974-1977 Medical Scientist Training Program Scholarship, Duke University School of Medicine 1976 Alpha Omega Alpha, Duke University School of Medicine 1987-1988 Jerome W. Conn Award for Distinguished Research by a Junior Faculty Member, University of Michigan, Department of Internal Medicine 1988 The Frank E. Trobaugh Hematology Young Investigator Award, Midwest Blood Club 1989 Elected to American Society for Clinical Investigation 1991 Royal College Visiting Professor, Queen's University, Kingston 1994 Elected to Association of American Physicians 1994 Appointed Warner-Lambert/Parke-Davis Professor of Medicine at the University of Michigan 1997 Investigator Recognition Award, Eighth Biennial Awards for Contributions to Hemostasis at the XVIth Congress of the International Society on Thrombosis and Hemostasis, in Florence, Italy 1999 Distinguished Faculty Lectureship Award in Biomedical Research sponsored by the University of Michigan Medical School Biomedical Research Council 1999 Elected to the Institute of Medicine of the National Academy of Sciences 2000 Fall 1999 Medical Student Award for Teaching Excellence, University of Michigan Medical School 2000 E. Donnall Thomas Lecture and Prize, 2000 Meeting of the American Society of Hematology 2000 Distinguished Faculty Achievement Award, University of Michigan Medical School 2001 Elected to AAAS Fellowship, American Association for the Advancement of Science 2001-2011 NIH MERIT Award, National Institutes of Health 2002 ISFP Prize, International Society for Fibrinolysis and Proteolysis 2002 Sol Sherry Distinguished Lecture, Council on Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association 2003-James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics, University of Michigan 2003 Basic Research Prize, American Heart Association 2004 ASCI Award, American Society for Clinical Investigation Recent PublicationsLevy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H, Bouhassira EE, Upshaw JD Jr., Ginsburg D*, Tsai H-M. Mutations in a Novel Member of the ADAMTS Gene Family Cause Thrombotic Thrombocytopenic Purpura. Nature 413:488-494, 2001. [* corresponding author] Eitzman DT, Westrick RJ, Bi X, Manning SL, Wilkinson JE, Broze GJ, Ginsburg D. Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden. Circulation 105:2139-2142, 2002. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci USA 99:10042-10047, 2002. Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EGD, Kaufman RJ, Ginsburg D. Bleeding due to disruption of a cargo-specific ER to Golgi transport complex. Nature Genetics, 34:220-225, 2003. Yang TL, Pipe SW, Yang A, Ginsburg D. Biosynthetic origin and functional significance of platelet factor V. Blood, 102:2851-2855, 2003. Sun H, Yang TL, Yang A, Wang X, Ginsburg D. The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis. Blood, 102:2856-2861, 2003. Zhang B and Ginsburg D.† Getting secretory granules ready for prime time. Cell 115:372-373, 2003. Sun H, Ringdahl U, Homeister JW, Fay WP, Cary Engleberg NC, Yang AY, Rozek LS, Wang X, Sjˆbring U, Ginsburg D.Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305:1283-1286, 2004. Eitzman DT, Westrick RJ, Shen Y, Bodary PF, Gu S, Manning SL, Dobies SL, Ginsburg D. :Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation (In Press). Lab ProjectsCVís from interested candidates may be forwarded to ginsburg@umich.edu Additional Lab LinksCellular and Molecular Biology Program Howard Hughes Medical Institute Lab MembersPost Doctoral Fellows:David Buchner, Ph.D. Karl Desch, M.D. Jill Johnsen, M.D. David Motto, M.D., Ph.D. Jordan Shavit, M.D., Ph.D. Hongmin Sun, Ph.D. Fen-Lai Tan, M.D., Ph.D. Bin Zhang, Ph.D. Graduate Students:Andrea Baines John Bernat Abigail Fahim Heidi Lemmerhirt Randy Westrick Weirui Zhang Research Staff:Sarah Dobies Suzann Labun Sara Manning Beth McGee David Siemieniak Xixi Wang Angela Yang Guojing Zhu Undergraduates:Lindsey Korepta Patty Shay
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