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Faculty
Research InterestsAlan R. Saltiel, PhD investigates the hormone insulin and its role in regulating cellular sugar levels. This work is now expanding into an investigation of how cells send and receive signals, which may lead to new treatments for diabetes, as well as new understandings of colon cancer, heart disease, and nerve growth. Education1975 A.B. Zoology, Duke University 1980, Ph.D. Biochemistry, University of North Carolina Postgraduate TrainingPostdoctoral Research Scientist, Mentor: Pedro Cuatrecasas, Dept. of Molecular Biology1981-1984 Wellcome Research Laboratories Honors and Awards1975 Graduation with Magna Cum Laude Distinction, Duke University Recent PublicationsChiang, S-H, Hou, J.C., Hwang, J., Pessin, J.E. and Saltiel, A.R. “Cloning and Functional Characterization of Related TC10 Isoforms, a Subfamily of Rho Proteins Involved in Insulin-Stimulated Glucose Transport” (2002) J. Biol. Chem. 277, 13067 Liu, J., Kimura, A., Bauman, C.A. and Saltiel, A.R. “APS Mediates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes” (2002) Mol. Cell. Biol. 22, 3599 Kanzaki, M., Watson, R.T., Hou, J.C., Stamnes, M., Saltiel, A.R. and Pessin, J.E. ”The Small GTP-Binding Protein TC10 Differentially Regulates Two Distinct Populations of Filamentous Actin in 3T3L1 Adipocytes” (2002) Mol. Biol. Cell 13, 2334 Kimura, A., Mora, S., Shigematsu, S., Pessin, J.E. and Saltiel, A.R. “The Insulin Receptor Catalyzes the Tyrosine Phosphorylation of Caveolin 1” (2002) J. Biol. Chem. 277, 30153. Chang, L. Adams, R. and Saltiel, A.R. “The TC10-interacting Protein CIP4/2 is Required for Insulin-Stimulated Glut4 Translocation in 3T3L1 Adipocytes” (2002) Proc. Natl. Acad. Sci. USA 99, 12835 Watson, R.T., Furukawa, M., Chiang, S-H, Boeglin, D., Kanzaki, M., Saltiel, A.R. and Pessin, J.E. “The Exocytotic Trafficking of TC10 Occurs through both Classical and Nonclassical Secretory Transport Pathways in 3T3L1 Adipocytes” (2003) Mol. Cell. Biol. 23, 961 Zhang, M. Kimura, A. and Saltiel, A.R. “Cloning and Characterization of CAP Splicing Isoforms” (2003) Mol. Med. 9, 18 Inoue, M., Chang, L., Hwang, J., Chiang, S-H, and Saltiel, A.R. “The Exocyst Complex is Required for Targeting of Glut4 to the Plasma Membrane by Insulin” (2003) Nature 422, 629 Crosson, S.M., Printen, J., Kahn, A., Pessin, J.E., and Saltiel, A.R. “PTG Gene Deletion Causes Impaired Glycogen Synthesis and Developmental Insulin Resistance” (2003) J. Clin. Invest. 111: 1423 Chiang, S-H, Hwang, J., Legendre, M., Zhang, M., Kimura A. and Saltiel, A.R. “TCGAP, A Multidomain Rho GTPase Activating Protein that Regulates Insulin-Stimulated Glucose Transport” (2003) 22, 2679 Liu, J. DeYoung, S.M., Hwang, J., O’Leary, E. and. Saltiel, A.R. “The Roles of Cbl-b and c-Cbl in Insulin-Stimulated Glucose Transport” (2003) 278, 36754 Hu,J., Liu, J., Ghirlando, R., Saltiel, A.R., and Hubbard, S.R. “Structural Basis for Recruitment of the Adapter Protein APS to the Activated Insulin Receptor” (2003) Molecular Cell 12, 1379 Kanzaki, M., Mora, S., Huang, J., Saltiel, A.R. and Pessin, J.E. “Atypical Protein Kinase C (PKCz/l) is a convergent downstream target of the insulin-stimulated phosphatidylinositol (PI) 3-kinase and TC10 signaling pathways” (2004) J. Cell Biol. 164, 279 Lab ProjectsCVs from interested candidates may be forwarded to saltiel@umich.edu Additional Lab LinksMolecular and Integrative Physiology Cellular and Molecular Biology Program Lab MembersPost-Doctoral Fellows:Merlijn Bazuine, Ph.D.: bazuine@umich.edu Irfan Lodhi: irfan@umich.edu
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