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Faculty
Research InterestsThe research interests of the Weiss laboratory focus on the mechanisms used by normal and neoplastic cells to remodel the 3-dimensional extracellular matrix during events ranging from cell differentiation and tissue morphogenesis to tumor cell metastasis. Current areas of emphasis include the regulation of the epithelial-mesenchymal cell transformation program by the transcription factor, Snail, and the function of the membrane-type matrix metalloproteinases during development and neoplasia. Education1966-1970 Eastmoor High School, Columbus, Ohio 1970-1973 Undergraduate, Ohio State University, B.A., (Biological Sciences/Biochemistry) 1973-1977 Graduate/Professional, Ohio State University, College of Medicine, M.D. Postgraduate Training1977-1978 Resident, Washington University, Department of Pathology, Barnes Hospital, St. Louis, Missouri 1978-1980 Research Fellow, The University of Michigan Medical Center, Division of Hematology and Oncology, Ann Arbor, Michigan Honors and Awards1976 Landacre Research Award 1977 Landacre Research Award 1977 College of Medicine Award 1977 Department of Medicine Award 1977 Upjohn Achievement Award 1982 Jerome W. Conn Clinical Investigator Award for Excellence in Clinical Research 1983 Central Society for Clinical Research 1984 American Society for Clinical Investigation 1985 Central Clinical Research Club 1986-1991 Editorial Committee of the American Society for Clinical Investigation 1991 Association of American Physicians 1991-present E. Gifford and Love Barnett Upjohn Chair 1993 Young Investigator Award (National) American Federation for Clinical Research 1993-2003 NIH MERIT Award 1997-2002 Editor-in-Chief, Journal of Clinical Investigation 2001-present Institute of Medicine, National Academy of Sciences Recent PublicationsHotary, K.B., Yana, I., Sabeh, F., Li, X-Y, Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., Hiraoka, N., Weiss, S.J. Matrix metalloproteinases regulate fibrin-invasive activity via MT1-MMP-dependent and independent processes. Journal of Experimental Medicine 2002, 195:295-308. Chun, T-H., Sabeh, F., Ota, I., Murphy, H., McDonagh, K., Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., and Weiss, S.J. MT1-MMP-dependent neovessel formation within the confines of the 3-dimensional extracellular matrix. Journal of Cell Biology 2004, 167:757-767. Hotary, K., Li, X.Y., Allen, E., Stevens, S.L., and Weiss, S.J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes & Development 20:2673-2686, 2006. Yook, J.I., Li, X.Y., Ota, I., Hu, C., Kim, H.S., Kim, N.H., cha, S.Y., Ryu, J.K., Choi, Y.J., Kim, J., Fearon, E.R., and Weiss, S.A. A Wnt/Asin2/GSK3b cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biology 8:1398-1406, 2006. Yana, I., Sagara, H., Takaki, S., Takatsu, K., Nakamura, K., Nakao, K., Katsuki, M., Taniguchi, S., Aoki, T., Sato, H., Weiss, S.J., and Seiki, M. Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. Journal of Cell Science. 2007, 120:1607-1614. Zhai, Y., Hotary, K.B., Nan, B., Bosch, F.X., Munoz, N., Weiss, S.J.,
and Cho, K.R. Gene expression analysis of pre-invasive and invasive
cervical squamous cell carcinomas. Cancer Research 2007, in press. Li, XY., Ota, I., Yana, I., Sabeh, F., and Weiss, S.J. Molecular dissection of the structural machinery underlying the tissue-invasive activity of MT1-MMP. Molecular Biology Cell 2008, 19:3221-3233. Ouyang, M., Lu, S., Li, X.Y., Xu, J., Seong, J., Giepmans, B.N., Shyy, J.Y., Weiss, S.J., and Wang, Y. Polarized MT1-MMP activity in live cells visualized by FRET. Journal of Biological Chemistry 2008, 283:17740-17748. Rowe, R. G., and Weiss, S.J. Breaching the basement membrane: Who, when and how? Trends in Cell Biology 2008,18:560-574. Xiong, W., Knispel, R., MacTaggart, J., Greiner, T.C., Weiss, S.J., and Baxter, B.T. MT1-MMP regulates macrophage-dependent elastolytic activity and aneurysm formation in vivo. Journal of Biological Chemistry ePub Nov 14, 2008, doi:10/1074/jbc.M806239200. Lehti, K., Rose, N.F., Valavaara, S., Weiss, S.J. and Keski-Oja, J. MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1
processing. Journal of Cell Science 2009, 122:126-135. Additional Lab LinksCellular and Molecular Biology Program Lab Members Casey Hu, M..D.
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