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Faculty
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Stephen J. Weiss, M.D.
Upjohn Professor of Medicine and Oncology
5000 Life Sciences Institute
sjweiss@umich.edu
734/764-0030
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Research Interests
The research interests of the Weiss laboratory focus on the mechanisms used by normal and neoplastic cells to remodel the 3-dimensional extracellular matrix during events ranging from cell differentiation and tissue morphogenesis to tumor cell metastasis. Current areas of emphasis include the regulation of the epithelial-mesenchymal cell transformation program by the transcription factor, Snail, and the function of the membrane-type matrix metalloproteinases during development and neoplasia.
Education
1966-1970 Eastmoor High School, Columbus, Ohio
1970-1973 Undergraduate, Ohio State University, B.A., (Biological Sciences/Biochemistry)
1973-1977 Graduate/Professional, Ohio State University, College of Medicine, M.D.
Postgraduate Training
1977-1978 Resident, Washington University, Department of Pathology, Barnes Hospital, St. Louis, Missouri
1978-1980 Research Fellow, The University of Michigan Medical Center, Division of Hematology and Oncology, Ann Arbor, Michigan
Honors and Awards
1976 Landacre Research Award
1977 Landacre Research Award
1977 College of Medicine Award
1977 Department of Medicine Award
1977 Upjohn Achievement Award
1982 Jerome W. Conn Clinical Investigator Award for Excellence in Clinical Research
1983 Central Society for Clinical Research
1984 American Society for Clinical Investigation
1985 Central Clinical Research Club
1986-1991 Editorial Committee of the American Society for Clinical Investigation
1991 Association of American Physicians
1991-present E. Gifford and Love Barnett Upjohn Chair
1993 Young Investigator Award (National) American Federation for Clinical Research
1993-2003 NIH MERIT Award
1997-2002 Editor-in-Chief, Journal of Clinical Investigation
2001-present Institute of Medicine, National Academy of Sciences
2008-present Fellow, American Association for the Advancement of Science
2009 University of Michigan
Distinguished Faculty Award
Recent Publications
Hotary, K.B., Allen, E.D., Brooks, P.C., Datta, N.S., Long, M.W., Weiss, S.J. 2003. Membrane type-1 matrix metalloproteinase usurps tumor growth control imposed by the three-dimenstionl extracellular matrix. Cell 114:33-45
Sabeh, F., Ota, I., Holmbeck, K., Birkendal-Hansen, H., Soloway, P., Balbin, M., Lopez-Otin, C. Shapiro, S., Inada, M., Krane, S., Allen E. Chung, D., and Weiss, S.J. Tumor cell traffic through the
extracellular matrix is controlled by the membrane-anchored collagenase, MT1-MMP. Journal of Cell Biology 2004, 167:769-781.
Lehti, K., Allen, E., Birkedal-Hansen, H., Holmbeck, K., Miyake, Y., Chun, T.-H., Weiss, S.J., An MT1-MMP-PDGF receptor-β axis regulates mural cell investment of the microvasculature. Genes & Development 2005, 19:979-991.
Chun, T.H., Hotary, K.B., Sabeh, F., Saltiel, A.R., Holmbeck, K., Birkedal-Hansen, H., Allen, E.D., Weiss, S.J. A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell 2006, 125:577-591.
Hotary, K., Li, X.Y., Allen, E., Stevens, S.L., and Weiss, S.J. A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes & Development 20:2673-2686, 2006.
Yook, J.I., Li, X.Y., Ota, I., Hu, C., Kim, H.S., Kim, N.H., cha, S.Y., Ryu, J.K., Choi, Y.J., Kim, J., Fearon, E.R., and Weiss, S.A. A Wnt/Asin2/GSK3b cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biology 8:1398-1406, 2006.
Zhou, X., Rowe, R.G., Hiraoka, N., George, J.P., Wirtz, D., Mosher, D.F., Virtanen, I., Chernousov, M.A., and Weiss, S.J. Fibronectin fibrillogenesis regulates 3-dimensional neovessel formation. Genes & Development 2008, 22:1231-1243.
Li, XY., Ota, I., Yana, I., Sabeh, F., and Weiss, S.J. Molecular dissection of the structural machinery underlying the tissue-invasive activity of MT1-MMP. Molecular Biology Cell 2008, 19:3221-3233.
Rowe, R. G., and Weiss, S.J. Breaching the basement membrane: Who, when
and how? Trends in Cell Biology 2008,18:560-574.
Rowe, R.G., Li, X.-Y., Hu, Y., Saunders, T.L., Virtanen, I., Gardia de
Herreros, A., Becker, K.-F., Ingvarsen, S., Engelholm, L.H., Bommer,
G.T., Fearon, E.R., and Weiss, S.J. Mesenchymal cells reactivate Snail1
expression to drive 3-dimensional invasion programs. Journal of Cell
Biology 2009, 184:399-408.
Sabeh, F., Shimizu-Hirota, R., and Weiss, S.J. Protease-dependent
versus independent cancer cell invasion programs: 3-dimensional amoeboid
movement revisited. Journal of Cell Biology 2009, 185:11-19.
Rowe, R.G., and Weiss, S.J. Navigating ECM barriers at the invasive
front: The cancer cell-stroma interface. Annual Review of Cell and
Developmental Biology 2009,25;567-595.
Sabeh, F., Li, X.-Y., Saunders, T.L., Rowe, R.G., and Weiss, S.J.
Secreted versus membrane-anchored collagenases: Relative roles in
fibroblast-dependent collagenolysis and invasion. Journal of Biological
Chemistry 2009, 284:23001-23011.
Ota, I., Li, X.-Y., Hu, Y., and Weiss, S.J. Induction of a MT1-MMP and
MT2-MMP-dependent basement membrane transmigration program in cancer
cells by Snail1. Proceedings of the National Academy of Sciences 2009,
106:20318-20323.
Feinberg, T., Weiss, S.J. Developmental ECM sculpting: laying it down
and cutting it up. Developmental Cell 2009, 17:584-6.
Lu, C., Li, X.-Y., Hu, Y., Rowe, R.G., and Weiss, S.J. MT1-MMP
controls human mesenchymal stem cell trafficking and differentiation.
Blood 2010, 115:221-229.
Sabeh, F., Fox, D., and Weiss, S.J. MT1-MMP-Dependent regulation of
rheumatoid arthritis synoviocyte function. Journal of Immunology 2010,
184:6396-6406.
Chun, T.-H., Inoue, M., Morisaki, H., Yamanaka, I., Miyamoto, Y.,
Okamura, T., Sato-Kusubata, K., Weiss, S.J. A genetic link between
obesity and MMP14-dependent adipogenic collagen turnover. Diabetes 2010
Oct;59(10):2484-94.
Lab Projects
CVs from interested candidates may be forwarded to sjweiss@umich.edu
Additional Lab Links
Cellular and Molecular Biology Program
Lab Members
David Dudley, Ph.D.
Maria Dzaman, M.D.
Tamar Feinberg, B.S.
(Ph.D. graduate student)
Casey Hu, M.D.
Rosie Lemons, M.S.
Xiao-Yan Li, Ph.D.
Yongshun Lin, Ph.D.
Rui Liu, Ph.D.
Kevin Tri Nyugen, M.D.
Farideh Sabeth, Ph.D.
Ryoko Shimizu-Hirota, M.D., Ph.D..
Yi Tang, Ph.D.
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