Advanced Raman Microscopy & Chemical Imaging Lab


Recent publications

Papers in refereed journals (2009 onwards)

M Raghavan, ND Sahar, DH Kohn, MD Morris, “Age-specific profiles of tissue-level composition and mechanical properties in murine cortical bone”, Bone, 2012 (In press, corrected proof) [link]

PI Okagbare, MD Morris, “Polymer-capped fiber-optic Raman probe for non-invasive Raman spectroscopy”, Analyst, 2012,137, 77-81[link]

J-D McElderry, MR Kole, MD Morris, "Repeated freeze-thawing of bone tissue affects Raman bone quality measurements", J Biomed Opt., 2011, 16, 071407 [link]

J Xu, P Zhu, Z Gan, MD Morris, A Ramamoorthy, "Solid-state NMR spectroscopy provides atomic-level insights into the dehydration of cartilage", J Phys Chem B., 2011, 115(33), 9948-9954 [link]

FW Esmonde-White, KA Esmonde-White, MR Kole, SA Goldstein, BJ Roessler and MD Morris, "Biomedical tissue phantoms with controlled geometric and optical properties for Raman spectroscopy and tomography", Analyst, 2011, 136 (21), 4437 - 4446 [link]

KA Esmonde-White, FW Esmonde-White, MD Morris, and BJ Roessler, “Fiber-optic Raman Spectroscopy of Joint Tissues,” Analyst (2011) [link].

FW Esmonde-White, KA Esmonde-White, and MD Morris, “Minor Distortions with Major Consequences: Correcting Distortions in Imaging Spectrographs,” Appl Spectrosc 65 , 85 (2011) [link]

PI Okagbare, FWL Esmonde-White, SA Goldstein, and MD Morris, “Development of non-invasive Raman spectroscopy for in vivo evaluation of bone graft osseointegration in a rat model,” Analyst 135, 3142 (2010) [link]

J Xu, P Zhu, Z Gan, ND Sahar, M Tecklenburg, MD Morris, DH Kohn, A Ramamoorthy, "Natural-abundance 43Ca solid-state NMR spectroscopy of bone", J Am Chem Soc., 2010, 132(33), 11504-11509 [link]

M Raghavan, ND Sahar, RH Wilson, MA Mycek, N Pleshko, DH Kohn, MD Morris, “Quantitative polarized Raman spectroscopy in highly turbid bone tissue”, Journal of Biomedical Optics, 2010, 2010; 15: 037001-07 [link]

M. V. Schulmerich, J. H. Cole, J. M. Kreider, F. W.L. Esmonde-White, K. A. Dooley, S. A. Goldstein, and M. D. Morris, “Transcutaneous Raman Spectroscopy of Murine Bone In Vivo,” Applied Spectroscopy 63 , 286-295 (2009) [link].

K. A. Esmonde-White, G. S. Mandair, F. Raaii, J. A. Jacobson, B. S. Miller, A. G. Urquhart, B. J. Roessler, and M. D. Morris, “Raman spectroscopy of synovial fluid as a tool for diagnosing osteoarthritis,” J. Biomed. Opt. 14 , 034013 (2009) [link].

KA Dooley, MD Morris, J McCormack, DP Fyhrie, "Stress mapping of undamaged, strained and failed regions of bone using Raman spectroscopy", J. Biomed. Opt. 14, 044018 (2009) [link]

P Zhu, J Xu, ND Sahar, MD Morris, DH Kohn, A Ramamoorthy, "Time-resolved dehydration-induced structural changes in an intact bovine cortical bone revealed by solid-state NMR spectroscopy", J Am Chem Soc, 2009, 131(47), 17064-65 [link]



Book Chapters (2008 onwards)

MD Morris, P Matousek (Eds.), "Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields", Springer (2010) [link]

GS Mandair, MD Morris, Raman Assessment of Bone Quality, in Clinical Orthopedics in Clinical Orthopedics and Related Research (2010) [link]

NA Macleod, MD Morris & P Matousek, "Characterization of deep layers of tissue and powders: Spatially offset Raman and transmission Raman spectroscopy", Emerging Raman Applications and Techniques in Biomedical and Pharmacuetical Fields, 47-69 (2010) [link]

GS Mandair and MD Morris, "Biomedical Applications of Raman Imaging, in Raman, Infrared and Near-infrared Chemical Imaging", edited by Ozaki, Y and Sasic, S., J. Wiley (2010) [link]

F. W. Esmonde-White and M. D. Morris, “Raman Imaging and Raman Mapping,” Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields , 97–110 (2010) [link]

K Esmonde-White, M Raghavan & MD Morris, "Raman Scattering I: Speciation and Analysis" in Encyclopedia of Applied Spectroscopy, edited by David Andrews, J. Wiley (2009) [link]

MD Morris, MV Schulmerich, KA Dooley, K Esmonde-White, "Vibrational Spectroscopic Imaging of Hard Tissue, in Infrared and Raman Spectroscopic Imaging", edited by R. Salzer and H. W. Siesler, Wiley-VCH, 149-172 (2009) [link]


Proceedings from conferences and symposia (2010 onwards)

KA Esmonde-White, FW Esmonde-White, C Holmes, MD Morris, B Roessler, "Assessing Pathological Bone Mineralization for Early Detection of Osteomyelitis", Orthopedic Research Society Transactions, Vol. 37, 0909 (2012)

B Gong, C Tchanque-Foussuo, B Poushanchi, SR Buchman, SA Goldstein, MD Morris, "Raman spectroscopy revelas strengths and limitations of Amifostine protection on irradiated bone", Orthopedic Research Society Transactions, Vol. 37, 0269 (2012)

M Raghavan, MS Davis, FW Esmonde-White, JC Marini, A Shih, MD Morris, K Kozloff, "Microdamage-induced Compositional Changes in Brtl/+ and Wildtype Mice: A Raman Imaging Study", Orthopedic Research Society Transactions, Vol. 37, 1347 (2012)

PI Okagbare, FW Esmonde-White, DL Begun, SA Goldstein, MD Morris, "Evaluation of Fracture Healing and Osseointegration: a Rat Tibia Model for Non-invasive Raman Spectroscopy", Orthopedic Research Society Transactions, Vol. 37, 1400 (2012)

PI Okagbare, MD Morris, "Polymer-capped fiber-optic Raman probe for in-vivo non-invasive Raman tomography and spectroscopy", Proc. SPIE 8207, 82076J (2012) [link]

A Khmaladze, A Ganguly, M Raghavan, S Kuo, JH Cole, CL Marcelo, SE Feinberg, MD Morris, K Izumi, "Raman spectroscopic analysis of human tissue engineered mucosa constructs (EVPOME) perturbed by physical and biochemical methods", Proc. SPIE 8219, 82190J (2012) [link]

PI Okagbare, FWL Esmonde-White, SA Goldstein, MD Morris, "Transcutaneous Raman spectroscopy for assessing progress of bone-graft incorporation in bone reconstruction and repair", Proc. SPIE 7883, 78834I (2011) [link]

M Raghavan, N Sahar N, MD Morris, DH Kohn, “Unsupervised Age-based Classification of Murine Cortical Bone Quality Using Nonlinear Combined Raman and Nanoindentation Metrics”, Orthopedic Research Society Transactions, Vol. 36, 0326 (2011) [link]

F. W. L. Esmonde-White, K. A. Esmonde-White, and M. D. Morris, “Exposed and Transcutaneous Measurement of Musculoskeletal Tissues using Fiber Optic Coupled Raman Spectroscopy,” Proc. SPIE 7548 , A. Mandelis, Ed., 75484D-6 (2010) [link]

G. S. Mandair, F. W. L. Esmonde-White, M. P. Akhter, A. M. Swift, J. Kreider, S. A. Goldstein, R. R. Recker, and M. D.. Morris, “Potential of Raman spectroscopy for evaluation of bone quality in osteoporosis patients: results of a prospective study,” presented at Photonic Therapeutics and Diagnostics VI, 2010, San Francisco, California, USA, 754846-754846-9 (Invited) [link].

J-D P McElderry, G Zhao, Q Yang, G Mandair, RT Franceschi, MD Morris, "Raman spectroscopic evidence of crystalline phosphate precursor to bone apatitic mineral", Proc. SPIE 7548, 754849 (2010) [link]

K. A. Dooley, F. W. L. Esmonde-White, and M. D. Morris, “Optical fiber bundle coupling errors in Raman spectra: correction via data processing,” presented at Biomedical Vibrational Spectroscopy IV: Advances in Research and Industry, 2010, San Francisco, California, USA, 75600O-75600O-5 [link].

ND Sahar, M Raghavan, MD Morris, DH Kohn, “Compositional changes of bone mineral and matrix have correlations with mechanical properties that may depend on bone age”, Orthopedic Research Society Transactions, 2010 [link]

MD Morris, "Non-invasive and minimally invasive Raman spectroscopic diagnostics for musculoskeletal tissue disorders", Proceedings of XXII International Conference on Raman Spectroscopy, vol. 1267, 129-130 (2010) [link]