Advanced Raman Microscopy & Chemical Imaging Lab


In Vivo and Transcutaneous Raman Spectroscopy and Tissue Optics

Raman spectroscopy can provide information about the quality and fracture susceptibility of bone. However, the light scattering properties of tissue complicate non-invasive measurement. The use of near-infrared lasers and specialized fiber optic probes enable non-invasive recovery of bone Raman spectra and even Raman maps.

Our laboratory has demonstrated recovery of bone spectra through extended depths of tissue. We have performed and validated non-invasive bone Raman spectroscopy on on live, anaesthetized mice and, with collaborators at Dartmouth University, have demonstrated diffuse Raman tomography.