Cunming Duan Ph.D.
| 3065B Kraus Natural Science Building |
| Ann Arbor, MI 48109 |
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Our laboratory is interested in understanding the roles of peptide growth factors in neuronal tissue formation and growth and the underlying molecular and cellular mechanisms. Our research focuses on the insulin-like growth factor (IGF) signaling system, including the IGF ligands, IGF binding proteins, IGF receptors, and the downstream signal transduction mechanisms. We have discovered that ablation of the IGF-I receptor disrupts the formation of eye, forebrain, and inner ear in zebrafish. We have recently characterized several IGF binding proteins from zebrafish and are investigating their roles in regulating IGF actions on neuronal cell proliferation, differentiation, and apoptosis in vivo Our laboratory also studies roles of IGF signaling system in regulating cell proliferation, differentiation, migration, and apoptosis and the underlying signal transduction mechanisms using mammalian cell culture systems.
Wood, A.W., Schlueter, P.J., and Duan, C. (2005). Targeted knockdown of insulin-like growth factor binding protein-2 (IGFBP-2) disrupts cardiovascular development in zebrafish embryos. Mol. Endocrinol. In press.
Kajimura, S., Aida, K., and Duan, C. (2005). Insulin-like growth factor binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc. Natl. Acad. Sci. USA. 102: 1240-1245.
Li, Y., Xiang, J.H., and Duan, C. (2005). Insulin-like growth factor binding protein-3 (IGFBP-3) plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation. J. Biol. Chem. 280: 3613-3620.
Xu, Q., Li, S., Zhao, Y., Maures, T.J., Yin, P., and Duan, C. (2004). "Evidence that IGF binding protein-5 functions as a ligand-independent transcriptional regulator in vascular smooth muscle cells." Cir. Res. 94: e46-54.
Yin, P., Xu, Q., and Duan, C. (2004). "Paradoxical actions of endogenous and exogenous insulin-like growth factor binding protein (IGFBP)-5 revealed by RNA interference analysis." J. Biol. Chem. 279: 32660-32666.
Xu, Q., Yan, B., Li, S., and Duan, C. (2004). Fibronectin binds insulin-like growth factor binding protein (IGFBP)-5 and abolishes its ligand-dependent action on cell migration." J. Biol. Chem. 279: 4269-4277.
Hsieh,T. Gordon, R., Clemmons, D.R., Busby, W.H. Jr., and Duan, C. (2003). Regulation of the mitogenic and chemotactic responses of vascular smooth muscle cells to insulin-like growth factor (IGF)-I by local IGF binding proteins. J. Biol. Chem. 278: 42886-42892.
Maures, T., Chan, S.J., Xu, B., Ding, J., Sun, H., and Duan, C. (2002). "Structural, biochemical, and expression analysis of two distinct insulin-like growth factor (IGF)-I receptors and their ligands in zebrafish." Endocrinology 143: 1858-1871.
Duan, C. (2002). "Specifying the cellular responses to insulin-like growth factor (IGF) signals: Role of IGF binding proteins." J. Endocrinol. 175: 41-54.
Maures, T., and Duan, C. (2002). "Structure, developmental expression, and physiological regulation of zebrafish insulin-like growth factor binding protein-1." Endocrinology 143: 2722-2731.
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