David J Fink M.D.
| 1914 Taubman Center |
| Ann Arbor, MI 48109 |
The Mata-Fink laboratory, co-directed by Drs. David Fink and Marina Mata, is located in the Biomedical Sciences Research Building on the campus of the University of Michigan Medical School and at the affiliated VA Ann Arbor Healthcare System. Research in the lab is focused on the development of modified herpes simplex virus (HSV) based gene transfer vectors as tools for understanding - and the development of novel treatments for - disorders of the nervous system. The first human trial of these vectors began at the University of Michigan in September 2008.
For a more detailed description of ongoing research projects, please see the Mata-Fink laboratory webpage (www.med.umich.edu/neurology/mata-fink_lab).
Chattopadhyay, M., Mata, M. and Fink, D.J. Continuous delta opioid receptor activation reduces neuronal voltage gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy. Journal of Neuroscience 28:6652-58, 2008
Mata, M., Hao, S.H., Fink, D.J., Gene therapy directed at the neuroimmune component of chronic pain with particular attention to the role of TNF alpha. Neuroscience Letters 437:209-13, 2008
Pohl, M. and Fink, D.J. A new player in gene therapy for pain? [Invited commentary]. Gene Therapy 15:953-54, 2008
Hao, S., Wolfe, D., Glorioso, J.C., Mata, M. and Fink, D.J. Effects of transgene-mediated endomorphin-2 in inflammatory pain. European Journal of Pain, EPub ahead of print, 2008
Zhou, Z., Peng, X., Hao, S., Fink, D.J., Mata, M. HSV-mediated transfer of interleukin-10 reduces inflammatory paion through modulation of membrane tumor necrosis factor alpha in spinal cord microglia. Gene Therapy 15:183-90, 2008.
Fink, D.J. Applications of gene therapy to the treatment of chronic pain. Current Gene Therapy 1:42-8, 2008
Hao, S, Mata, M, Fink, D.J. Viral vector-based gene transfer for treatment of chronic pain. International Anesthesiology Clinics 45:59-71, 2007.
Mata, M., Fink, D.J. Gene therapy for pain. Anesthesiology 106:1079-80, 2007.
Wolfe, D., Hao, S., Hu, J., Srinivasan, R., Goss, J., Mata, M., Fink, D.J., Glorioso, J. Engineering an endromorphin 2 gene for use in neuropathic pain therapy. Pain 133:29-38, 2007.
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