Elizabeth Young M.D.
| 1046 Mental Health Research Institute 0720 |
| Ann Arbor, MI 48109 |
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Our research focuses on the control of negative feedback in the hypothalamic pituitary adrenal axis and the role of steroid hormones in modulation of this feedback in both humans and experimental animals. Current studies are examining the role of gonadal steroids, estrogen and progesterone and their impact upon negative feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis in female humans and rats. This work will be extended to the study of interactions between the HPA and hypothalamic-pituitary-gonadal (HPG) axes in depressed women.
Young, E.A., Nesse, R.M., Weder, A., Julius ,S.: Anxiety and cardiovascular reactivity in the Tecumseh population, Journal Hypertension 16:1727-1733, 1998.
Lopez, J.F., Liberzon, I., Vazquez, D.M.,Young, E.A. and Watson, S.J.: Serotonin 1a receptor mRNA regulation in the hippocampus after acute stress. Biological Psychiatry 45:943-947, 1999.
Liberzon, I., Abelson, J.L., Flagel, S.B., Raz, J, and Young, E.A.: Neuroendocrine and psychophysiological responses in PTSD: A symptom provocation study. Neuropsychopharmacology 21:40-50, 1999.
Young, E.A., Aggen, S.H., Prescott, C.A., Kendler, K.S.: Similarity in saliva cortisol measures in monozygotic twins and the influence of past major depression. Biological Psychiatry. 48:70-4, 2000
Young, E.A., Lopez, J.F., Murphy-Weinberg, V., Watson, S.J., Akil, H.: Hormonal evidence for altered responsiveness to social stress in major depression. Neuropsychopharmacology. 23:411-8, 2000
Young, E.A., Midgley, A.R., Carlson, N.E., Brown, M.B.: Alteration in the hypothalamic-pituitary-ovarian axis in depressed women. [see comments]. Archives of General Psychiatry. 57:1157-62, 2000
Young EA, Altemus M, Lopez JF, Kocsis JH, Schatzberg AF, De Battista C, Zubieta JK. Relationship between HPA axis activation and the response to fluoxetine: a pilot study.Psychoneuroendocrinology , 29:1198-204, 2004
Young EA, Abelson JL and Cameron OG. Effect of Comorbid Anxiety Disorders on the HPA Axis Response to a Social Stressor in Major Depression, Biological Psychiatry,;56:113-20, 2004
Young EA and Breslau N Cortisol and Catecholamines in Posttraumatic Stress Disorder: A Community Study, Archives General Psychiatry, 61:394-401, 2004
Young EA, Abelson JL and Lightman S. Cortisol Pulsatility and its Role in Stress Regulation and Health, Frontiers of Neuroendocrinology, in press
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