Eva Feldman M.D.,Ph.D.
| 5017 BSRB Box 2200 |
| Ann Arbor, MI 48109 |
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Our laboratory focuses on the role of growth factors in neuronal growth and differentiation. We are specifically interested in the neurotrophic properties of the insulin-like growth factors I and II (IGF-I, IGF-II). We use molecular biology tools, recombinant DNA and protein biochemistry in our studies. We have shown that IGF-II is an autocrine growth factor in human neurons and, with IGF-I, enhances neurite outgrowth, neuroglial survival and protects neurons under physiologic stressors from undergoing programmed cell death.
We are also interested in the role of oxidative stress in the process of diabetic neuropathy and ALS. We utilize various oxidative stress measures to delineate the oxidative stress response to high gluocse for development of potential therapeutic agents.
Please visit the Program for Neurology Research and Discovery for more information.
The role of MTMR14 in autophagy and in muscle disease.
Gibbs EM, Feldman EL, Dowling JJ.
Autophagy. 2010 Aug 9;6(6). [Epub ahead of print]
PMID: 20595810 [PubMed - as supplied by publisher]
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2.p38 mediates mechanical allodynia in a mouse model of type 2 diabetes.
Cheng HT, Dauch JR, Oh SS, Hayes JM, Hong Y, Feldman EL.
Mol Pain. 2010 May 19;6:28.
PMID: 20482876 [PubMed - in process]Free PMC ArticleFree text
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3.Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.
Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O.
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10190-5. Epub 2010 May 17.
PMID: 20479236 [PubMed - indexed for MEDLINE]Free PMC ArticleFree text
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4.Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy.
Vincent AM, Edwards JL, McLean LL, Hong Y, Cerri F, Lopez I, Quattrini A, Feldman EL.
Acta Neuropathol. 2010 May 15. [Epub ahead of print]
PMID: 20473509 [PubMed - as supplied by publisher]
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5.DCCT and EDIC studies in type 1 diabetes: lessons for diabetic neuropathy regarding metabolic memory and natural history.
Pop-Busui R, Herman WH, Feldman EL, Low PA, Martin CL, Cleary PA, Waberski BH, Lachin JM, Albers JW; DCCT/EDIC Research Group.
Curr Diab Rep. 2010 Aug;10(4):276-82.
PMID: 20464532 [PubMed - in process]
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6.The Pleotrophic Effects of IGF-I on Human Spinal Cord Neural Progenitor Cells.
Lunn JS, Pacut C, Backus C, Hong Y, Johe K, Hefferan M, Feldman EL, Marsala M.
Stem Cells Dev. 2010 Apr 20. [Epub ahead of print]
PMID: 20406098 [PubMed - as supplied by publisher]
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7.Zebrafish MTMR14 is required for excitation-contraction coupling, developmental motor function and the regulation of autophagy.
Dowling JJ, Low SE, Busta AS, Feldman EL.
Hum Mol Genet. 2010 Jul 1;19(13):2668-81. Epub 2010 Apr 16.
PMID: 20400459 [PubMed - in process]
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8.Zebrafish models of collagen VI-related myopathies.
Telfer WR, Busta AS, Bonnemann CG, Feldman EL, Dowling JJ.
Hum Mol Genet. 2010 Jun 15;19(12):2433-44. Epub 2010 Mar 25.
PMID: 20338942 [PubMed - in process]Free PMC ArticleFree text
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9.Accelerated neuritogenesis and maturation of primary spinal motor neurons in response to nanofibers.
Gertz CC, Leach MK, Birrell LK, Martin DC, Feldman EL, Corey JM.
Dev Neurobiol. 2010 Jul;70(8):589-603.
PMID: 20213755 [PubMed - in process]
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10.Effect of prior intensive insulin treatment during the Diabetes Control and Complications Trial (DCCT) on peripheral neuropathy in type 1 diabetes during the Epidemiology of Diabetes Interventions and Complications (EDIC) Study.
Albers JW, Herman WH, Pop-Busui R, Feldman EL, Martin CL, Cleary PA, Waberski BH, Lachin JM; Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group.
Diabetes Care. 2010 May;33(5):1090-6. Epub 2010 Feb 11.
PMID: 20150297 [PubMed - in process]
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11.The management of diabetic neuropathy in CKD.
Pop-Busui R, Roberts L, Pennathur S, Kretzler M, Brosius FC, Feldman EL.
Am J Kidney Dis. 2010 Feb;55(2):365-85. Epub 2009 Dec 30. Review. No abstract available.
PMID: 20042258 [PubMed - indexed for MEDLINE]
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