Faye Silverstein M.D.
| 8301 Medical Science Research Building III 0646 |
| Ann Arbor, MI 48109 |
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The major focus of the laboratory is to identify pivotal cellular and molecular mechanisms that contribute to the pathogenesis of perinatal brain injury and to develop more effective therapeutic strategies, based on pharmacological and/or immunological antagonism of these mechanisms. Current projects are the roles of inflammatory mediators in neonatal brain injury and repair, examining the pathophysiology of neonatal oligodendroglial injury, and developing pharmacological strategies to enhance the efficacy of hypothermia for neuroprotection.
Liu, X.H., Kwon, D., Schielke, G., Yang, G.Y., Silverstein, F.S., Barks, J.D.E.: Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage. J. Cereb. Blood Flow Metab. 19:1099-1108, 1999
Galasso, J.M., Stegman, L.D., Blaivas, M., Harrison, J.K., Ross, B.D., Silverstein, F.S.: Experimental Gliosarcoma Induces Chemokine Receptor Expression in Rat Brain. Exp. Neurol. 161: 85-95, 2000.
Galasso, J.M., Liu, Y., Szaflarski, J., Warren, J.S., Silverstein, F.S., Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain. Neuroscience. 101:737-44, 2000
Cowell RM, Plane JM, Silverstein FS. Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. J Neurosci 23: 9459-68, 2003
Cowell RM, Silverstein FS. Developmental changes in the expression of chemokine receptor CCR1 in the rat cerebellum. J Comp Neurol 457: 7-23, 2003
Plane JM, Liu R, Wang T, Silverstein FS, Parent JM. Neonatal hypoxic-ischemic injury increases forebrain subventricular zone neurogenesis in the mouse. Neurobiology of Disease 16, 585-95, 2004
Liu YQ, Barks JDE, Xu G, Silverstein FS. Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats. Stroke 35, 1460-5, 2004
Ong J, Plane JM, Parent JM, Silverstein FS. Hypoxic-Ischemic Injury Stimulates Subventricular Zone Proliferation And Neurogenesis In The Neonatal Rat. Pediatr. Res 58:1-7, 2005
Cowell RM, Xu H, Parent JM, Silverstein FS. Microglial Expression of Chemokine Receptor CCR5 during Rat Forebrain Development and after Perinatal Hypoxia-Ischemia. J. Neuroimmunol, 173:55-65, 2006
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