Gina R. Poe Ph.D.
| 7433 Medical Sciences I 0615 |
| Ann Arbor, MI 48109 |
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Research in my lab combines interests in basic sleep processes, development, learning and memory, and optimization of cognitive performance. We use multiple microelectrodes to measure activity from tens of neurons simultaneously in the freely behaving animal hippocampus. We have found a neural discharge pattern that could explain why REM sleep is important to synaptic reorganization in general, which includes the synaptic changes that occur during learning and normal development.
Detailed investigation of these neural processes should uncover the normal mechanisms underlying the role of sleep in learning and memory and explain cognitive declines that parallel REM sleep disruptions, such as in certain cases of mental retardation and in the normal aging process.
Walsh CM, Booth V, Poe GR. Spatial and reversal learning in the Morris water maze are largely resistant to six hours of REM sleep deprivation following training. Learn Mem. 2011 Jun 15;18(7):422-34.
Poe GR, Walsh CM, Bjorness TE. Cognitive neuroscience of sleep. Prog Brain Res. 2010;185:1-19.
Poe GR, Walsh CM, Bjorness TE. Both duration and timing of sleep are important to memory consolidation. Sleep. 2010 Oct;33(10):1277-8.
Mashour GA, Lipinski WJ, Matlen LB, Walker AJ, Turner AM, Schoen W, Lee U, Poe GR. Isoflurane anesthesia does not satisfy the homeostatic need for rapid eye movement sleep. Anesth Analg. 2010 May 1;110(5):1283-9.
Gross BA, Walsh CM, Turakhia AA, Booth V, Mashour GA, Poe GR. Open-source logic-based automated sleep scoring software using electrophysiological recordings in rats. J Neurosci Methods. 2009 Oct 30;184(1):10-8. Epub 2009 Jul 15.
Wang JX, Poe G, Zochowski M. From network heterogeneities to familiarity detection and hippocampal memory management. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Oct;78(4 Pt 1):041905.
Reasor JD, Poe GR. Learning and memory during sleep and anesthesia. Int Anesthesiol Clin. 2008 Summer;46(3):105-29.
Best J, Diniz Behn C, Poe GR, Booth V. Neuronal models for sleep-wake regulation and synaptic reorganization in the sleeping hippocampus. J Biol Rhythms. 2007 Jun;22(3):220-32.
Booth V, Poe GR. Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: relevance to REM sleep reactivation and memory consolidation. Hippocampus, 16(2):161-73, 2006.
Bjorness TE, Riley BT, Tysor MK, Poe GR. REM restriction persistently alters strategy used to solve a spatial task. Learning and Memory, 12(3):352-9, 2005.
Poe GR, Rector DM, Harper RM. State-dependent columnar organization of dorsal hippocampal activity in the freely-behaving cat. Behavioral Brain Research, 138(1):107-12, 2003.
Knierim JJ, McNaughton BL, Poe GR. Three-dimensional spatial selectivity of hippocampal neurons during space flight. Nature Neuroscience, 3:209-10, 2000.
Poe GR, Teed RG, Insel N, White R, McNaughton BL. Barnes CA. Partial hippocampal inactivation: effects on spatial memory performance in aged and young rats. Behavioral Neuroscience, 114:940-9, 2000.
Poe GR, Nitz DA, McNaughton BL, Barnes CA. Experience-dependent phase-reversal of hippocampal neuron firing during REM sleep. Brain Research, 855:176-80, 2000.
Poe GR, Rector DM, Harper RM. Hippocampal reflected optical patterns during sleep and waking states in the freely behaving cat. J Neurosci 14(5):2933-2942, 1994.
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