George A. Mashour M.D., Ph.D.
| 1H247 University Hospital, Box 0048 |
| Ann Arbor, MI 48109 |
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Dr. Mashour received his M.D. and Ph.D in Neuroscience from Georgetown University and was awarded Fulbright Scholarships for neuroscience research at the University of Berlin and the University of Bonn. He completed his internship, residency, and chief residency in anesthesiology at the Massachusetts General Hospital and Harvard Medical School, as well as fellowship training in neurosurgical anesthesia at the University of Michigan. His main clinical interests are neuroanesthesia and neurocritical care.
Although Dr. Mashour's doctoral and post-doctoral work focused on neuro-oncology (references #1-4 below), his interests have turned to the cognitive neuroscience of anesthesiology (references #5-9). He is currently investigating the interfaces of sleep and general anesthesia in association with Dr. Gina Poe, with a particular focus on REM activity and cognitive function. He is credited with developing the "cognitive unbinding" paradigm of general anesthesia and advocating for the role of anesthesiology in the study of consciousness. Clinically, Dr. Mashour is studying awareness during general anesthesia and electroencephalographic techniques to prevent it. He is also currently editing an interdisciplinary book on the subject of unconscious processes.
Mashour GA, Ratner N, Khan G, Martuza RL, Kurtz A. The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofibroma-derived cells. Oncogene 2001; 20(1):97-106
Mashour GA, Moulding HD, Chalavi A, Driever P, Rabkin SD, Martuza RL, Kurtz A. Therapeutic efficacy of G207 in a novel peripheral nerve sheath tumor model. Experimental Neurology 2001; 169:64-71
Mashour GA, Hartmann M, Drissel SN, Scharf B, Sadatoshi S, Driever PH, Mautner VM, Kurtz A. Circulating growth factor serum levels are associated with tumorigenesis in neurofibromatosis type 1. Clinical Cancer Research 2004; 10:5677-5683 (Published as a Featured Article)
Mashour GA, Drissel SN, Frahm S, Farassati F, Martuza RL, Mautner VF, Kindler-Rohrborn A, Kurtz A. Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. Oncogene 2005; 24(14):2367-2374
Mashour GA. Consciousness unbound: Toward a paradigm of general anesthesia. Anesthesiology 2004; 100:428-433 (Published as a Special Article)
Mashour GA. Integrating the science of consciousness and anesthesia. Anesthesia & Analgesia 2006; 103:975-82
Mashour GA. Monitoring consciousness: EEG-based assessment of anesthetic depth. Seminars in Anesthesia, Perioperative Medicine and Pain, 2006; 25(4):205-10
Brusseau RR, Mashour GA. Subcortical consciousness: Implications for fetal anesthesia and analgesia. Behavioral and Brain Sciences, 2007; 30(1):86-7
Mashour GA, Turner CR, Vandervest JC, Tremper KK. The reported incidence of undesired intraoperative awareness is comparable in general vs. non-general anesthetics. In revision, Anesthesia and Analgesia
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