Israel Liberzon M.D.
| Rachel Upjohn Building |
| 4250 Plymouth Rd |
| Ann Arbor, MI 48109 |
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My research and clinical interest focus on stress and stress related disorders. In our Trauma, Stress and Anxiety Research Group, and Psychiatry Affective Neuroscience laboratory we are conducting neuroimaging, neuroendocrine and pharmacological studies in both healthy controls and clinical population. In our wet bench laboratory we are engaged in biochemical and molecular biological studies and also are developing animal modes for these conditions. Co-regulation, and dysregulation of stress response systems (HPA, catecholaminergic, and peripheral autonomic) comprise our main research directions in humans. In animal research, in addition to developing models for post-traumatic stress, we continue to explore the effects of stress and stress hormones on neuropeptide receptor, receptor mRNA regulation, and on animal behaviors.
In our in vivo neuroimaging work, we explore functional neuroanatomy of stress, emotions, and cognitive -emotional interaction as well as effects of emotions on decision making. We are developing integrated approaches that combine psychological, neuroimaging and neuroendocrinological aprroaches and apply them to psychiatric patients in attempt to better understand the development of psychiatric psychopatology.
Liberzon, I., Lopez, J., Vazquez, D., Flagel, S.B., Young, E.A.: Differential regulation of hippocampal glucocorticoid receptors and negative feedback: relevance to PTSD. Journal of Neuroendocrinology. 1999; 11:11-17
Liberzon, I., Fig, L.M., Taylor, S.F., Jung, T.D., Chamberlain, K.R., Minoshima, S., Koeppe, R.A.: SPECT imaging in PTSD: Activation studies. Biological Psychiatry. 45:817-826, 1999.
Liberzon, I., Abelson, J.L., Flagel, S.B., Raz, J., Young, E.A.: Neuroendocrine and psychophysiologic responses in PTSD: symptom provocation studies. Neuropsychopharmacology. 21:40-50, 1999.
Phan KL, Wager T, Taylor SF, Liberzon I: Functional Neuroanatomy of Emotion: A Meta-analysis of Emotion Activation Studies in PET and fMRI. NeuroImage, 2002; 16:331-348
Liberzon I, Phan KL, Decker LR, Taylor SF: Extended amygdala and emotional salience: A PET investigation of positive and negative affect. Neuropsychopharmacology, 2003;28:726-733
Liberzon, I., Taylor, S.F., Fig, L.M., Decker, L.R., Koeppe, R.A., Minoshima, S.: Limbic activation and psychophysiologic responses to aversive visual stimuli. Interaction with cognitive task. Neuropsychopharmacology. 23:508-16, 2000
Seng, J.S., Oakley, D.J., Sampselle, C.M., Killion, C., Graham-Bermann, S., Liberzon, I.: Posttraumatic Stress Disorder is Associated with Complications of Pregnancy. Obstet. Gynecol. 97:17-22, 2001
Liberzon I, Phan KL, Khan S, Abelson JL: Role of the GABAA receptor in anxiety: Evidence from animal models, molecular and clinical psychopharmacology and brain imaging studies. Current Neuropharmacology, 2003;1 (3): 267-283
Khan S, Liberzon I: Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD. Psychopharmacology, 2004; March 172(2):225-9
Phan KL, Britton JC, Taylor SF, Fig LM, Liberzon I: Cortico-Limbic Blood Flow During Non-traumatic Emotional Processing in PTSD. Archives of General Psychiatry In Press
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