Mohammed Akaaboune Ph.D.
| 3127 Natural Science Bldg. 1048 |
| Ann Arbor, MI 48109 |
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The major interest in this lab is the regulation of synaptic connections during development, maturity and aging. One major approach is to use state-of-the-art imaging methods to observe the structure of synapses in living animals. Many studies take advantage of novel methods developed by Dr. Akaaboune to follow the dynamics of synaptic proteins over time in the same animal. Both wild type mice and mice modified by the targeted deletion of genes or the insertion of transgenes are currently under study.
Martinez-Pena Y Valenzuela I, Akaaboune M. Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice. Mol Biol Cell. 2007 Aug;18(8):2904-11.
Bruneau E, Akaaboune M.he dynamics of the rapsyn scaffolding protein at individual acetylcholine receptor clusters.J Biol Chem. 2007 Mar 30;282(13):9932-40.
Bruneau EG, Akaaboune M. The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo.Development. 2006 Nov;133(22):4485-93.
Krejci E, Martinez-Pena y Valenzuela I, Ameziane R, Akaaboune M. Acetylcholinesterase dynamics at the neuromuscular junction of live animals. J Biol Chem. 2006 Apr 14;281(15):10347-54.
Bruneau EG, Akaaboune M. Running to stand still: ionotropic receptor dynamics at central and peripheral synapses.Mol Neurobiol. 2006 Oct;34(2):137-51.
Bruneau E, Sutter D, Hume RI, Akaaboune M. Identification of nicotinic acetylcholine receptor recycling and its role in maintaining receptor density at the neuromuscular junction in vivo. J Neurosci. 2005 Oct 26;25(43):9949-59.
Martinez-Pena y Valenzuela I, Hume RI, Krejci E, Akaaboune M. In vivo regulation of acetylcholinesterase insertion at the neuromuscular junction. J Biol Chem. 2005 Sep 9;280(36):31801-8.
Grady RM, Akaaboune M, Cohen AL, Maimone MM, Lichtman JW, Sanes JR.Tyrosine-phosphorylated and nonphosphorylated isoforms of alpha-dystrobrevin: roles in skeletal muscle and its neuromuscular and myotendinous junctions. J Cell Biol. 2003 Mar 3;160(5):741-52. Epub 2003 Feb 25
Akaaboune M, Grady RM, Turney S, Sanes JR, and Lichtman JW, Neurotransmitter Receptor Dynamics Studied In Vivo by Reversible Photo-Unbinding of Fluorescent Ligands. Neuron 2002 34: 865-876
Akaaboune M. Culican SM. Turney SG. Lichtman JW. Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo. Science. 28:503-7, 1999
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